KEGG   Homo sapiens (human): 22808
Entry
22808             CDS       T01001                                 
Symbol
MRAS, M-RAs, NS11, R-RAS3, RRAS3
Name
(RefSeq) muscle RAS oncogene homolog
  KO
K07831  Ras-related protein M-Ras
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
hsa04218  Cellular senescence
hsa04371  Apelin signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04810  Regulation of actin cytoskeleton
hsa05205  Proteoglycans in cancer
Network
nt06526  MAPK signaling
  Element
N01598  Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Disease
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    22808 (MRAS)
   04014 Ras signaling pathway
    22808 (MRAS)
   04015 Rap1 signaling pathway
    22808 (MRAS)
   04371 Apelin signaling pathway
    22808 (MRAS)
   04072 Phospholipase D signaling pathway
    22808 (MRAS)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    22808 (MRAS)
   04137 Mitophagy - animal
    22808 (MRAS)
  09143 Cell growth and death
   04218 Cellular senescence
    22808 (MRAS)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    22808 (MRAS)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    22808 (MRAS)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    22808 (MRAS)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins [BR:hsa04031]
    22808 (MRAS)
GTP-binding proteins [BR:hsa04031]
 Small (monomeric) G-proteins
  Ras Family
   Ras [OT]
    22808 (MRAS)
SSDB
Motif
Pfam: Ras Roc GTP_EFTU Arf RsgA_GTPase MMR_HSR1 ATP_bind_1 AAA_16 MMR_HSR1_Xtn
Other DBs
NCBI-GeneID: 22808
NCBI-ProteinID: NP_001078518
OMIM: 608435
HGNC: 7227
Ensembl: ENSG00000158186
UniProt: O14807 Q6FGP0 Q8WVM9
Structure
LinkDB
Position
3:138347648..138405535
AA seq 208 aa
MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQW
AILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFP
MILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQIP
EKSQKKKKKTKWRGDRATGTHKLQCVIL
NT seq 627 nt   +upstreamnt  +downstreamnt
atggcaaccagcgccgtccccagtgacaacctccccacatacaagctggtggtggtgggg
gatgggggtgtgggcaaaagtgccctcaccatccagtttttccagaagatctttgtgcct
gactatgaccccaccattgaagactcctacctgaaacatacggagattgacaatcaatgg
gccatcttggacgttctggacacagctgggcaggaggaattcagcgccatgcgggagcaa
tacatgcgcacgggggatggcttcctcatcgtctactccgtcactgacaaggccagcttt
gagcacgtggaccgcttccaccagcttatcctgcgcgtcaaagacagggagtcattcccg
atgatcctcgtggccaacaaggtcgatttgatgcacttgaggaagatcaccagggagcaa
ggaaaagaaatggcgaccaaacacaatattccgtacatagaaaccagtgccaaggaccca
cctctcaatgtcgacaaagccttccatgacctcgttagagtaattaggcaacagattccg
gaaaaaagccagaagaagaagaagaaaaccaaatggcggggagaccgggccacaggcacc
cacaaactgcaatgtgtgatcttgtga

KEGG   Homo sapiens (human): 8036
Entry
8036              CDS       T01001                                 
Symbol
SHOC2, NSLH1, SIAA0862, SOC2, SUR8
Name
(RefSeq) SHOC2 leucine rich repeat scaffold protein
  KO
K19613  leucine-rich repeat protein SHOC2
Organism
hsa  Homo sapiens (human)
Pathway
hsa04014  Ras signaling pathway
Network
nt06526  MAPK signaling
  Element
N01598  Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Disease
H00523  Noonan syndrome and related disorders
H02191  Noonan-like syndrome with loose anagen hair
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    8036 (SHOC2)
SSDB
Motif
Pfam: LRR_8 LRR_4 LRR_1 LRR_9 NKWYS
Other DBs
NCBI-GeneID: 8036
NCBI-ProteinID: NP_001311265
OMIM: 602775
HGNC: 15454
Ensembl: ENSG00000108061
UniProt: Q9UQ13
Structure
LinkDB
Position
10:110919370..111013665
AA seq 582 aa
MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKDSSAA
QPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIK
ELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNK
LREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNL
ITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIP
RSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSL
NMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPED
VSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTN
NQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALC
SKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV
NT seq 1749 nt   +upstreamnt  +downstreamnt
atgagtagtagtttaggaaaagaaaaagactctaaagaaaaagatcccaaagtaccatca
gccaaggaaagagaaaaggaggcaaaagcctctggaggttttgggaaagagagcaaagaa
aaagaacctaagaccaaagggaaagatgccaaagatggaaagaaggactccagtgctgcc
caaccaggggtggcattttcagttgacaatacgatcaaacggccaaacccagcacctggg
actagaaaaaaatccagcaatgcagaggtgattaaagagctcaacaaatgccgggaagag
aattcaatgcgtttggacttatccaagagatctatacacatattgccatcatcaatcaaa
gagttgactcaattaacagaactttatttatacagtaacaaattgcagtccctcccagca
gaggtgggatgtttagtaaatctcatgacactggctctaagtgaaaattcacttaccagt
ttgcctgactctcttgataacttgaagaagctgcggatgcttgatttacggcataataaa
ctgagagaaattccttcagtggtgtataggctggattctctcaccactctttaccttcgc
tttaatcgtataactactgtggaaaaggacatcaaaaacttgtcaaaactcagcatgctt
agcattcgagagaacaaaattaaacaactacctgctgaaattggtgaattatgtaacctc
attacgctggatgtagctcacaatcaacttgaacaccttccaaaggagattggaaactgt
acacagataaccaaccttgacttgcagcacaatgaactgctagacctcccagatactata
ggaaacctgtccagtttaagtcgtcttggtctgagatataacagactgtcagcaataccc
agatcattagcaaaatgcagtgcacttgaagaattaaatttagagaacaataacatttct
actttaccagagagtcttttatcaagtcttgtgaaactgaatagtttgaccttagctaga
aattgcttccagttgtatccagtgggtggtccatctcagttttctaccatctattccctc
aacatggaacacaatcgaatcaacaaaattccatttggaattttctccagagcaaaagta
ttaagtaagctgaatatgaaggacaatcagttaacatcacttcccttggattttggaact
tggaccagtatggtagaattgaatttagccactaatcagctcacaaagatccctgaggat
gtgtctggtctcgtttctcttgaggttcttatcttatcaaacaatcttctaaagaagctt
ccccatggtcttggaaaccttaggaagttaagagagttggatctagaagagaacaaattg
gaatccttgccaaatgaaattgcatatcttaaggatttacagaaattagtcttgacaaac
aaccagttgaccactcttcccagaggcattggtcaccttactaatctcacacatctgggc
cttggagagaacctacttactcaccttcctgaagaaattggtacactggagaacctagaa
gaactgtatttgaatgacaaccccaacctgcatagccttccctttgagctggcactctgc
agcaagctttcaatcatgagtattgagaactgtccactcagtcaccttccacctcagatt
gttgctggggggccttctttcatcattcagttcttaaagatgcagggtccatatcgtgcc
atggtctga

KEGG   Homo sapiens (human): 5499
Entry
5499              CDS       T01001                                 
Symbol
PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A
Name
(RefSeq) protein phosphatase 1 catalytic subunit alpha
  KO
K06269  serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04114  Oocyte meiosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04611  Platelet activation
hsa04720  Long-term potentiation
hsa04728  Dopaminergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04931  Insulin resistance
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05168  Herpes simplex virus 1 infection
hsa05205  Proteoglycans in cancer
hsa05415  Diabetic cardiomyopathy
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06515  Regulation of kinetochore-microtubule interactions
nt06526  MAPK signaling
  Element
N00572  HSV ICP34.5 to PKR-eIF2alpha signaling pathway
N01531  CENPE interaction with NDC80 complex
N01536  Dephosphorylation of kinetochore
N01598  Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    5499 (PPP1CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    5499 (PPP1CA)
   04024 cAMP signaling pathway
    5499 (PPP1CA)
   04022 cGMP-PKG signaling pathway
    5499 (PPP1CA)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    5499 (PPP1CA)
   04218 Cellular senescence
    5499 (PPP1CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5499 (PPP1CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5499 (PPP1CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5499 (PPP1CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5499 (PPP1CA)
   04921 Oxytocin signaling pathway
    5499 (PPP1CA)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5499 (PPP1CA)
   04270 Vascular smooth muscle contraction
    5499 (PPP1CA)
  09156 Nervous system
   04728 Dopaminergic synapse
    5499 (PPP1CA)
   04720 Long-term potentiation
    5499 (PPP1CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5499 (PPP1CA)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    5499 (PPP1CA)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    5499 (PPP1CA)
  09165 Substance dependence
   05031 Amphetamine addiction
    5499 (PPP1CA)
   05034 Alcoholism
    5499 (PPP1CA)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    5499 (PPP1CA)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5499 (PPP1CA)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5499 (PPP1CA)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    5499 (PPP1CA)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5499 (PPP1CA)
   03041 Spliceosome [BR:hsa03041]
    5499 (PPP1CA)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5499 (PPP1CA)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     5499 (PPP1CA)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     5499 (PPP1CA)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     5499 (PPP1CA)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    5499 (PPP1CA)
SSDB
Motif
Pfam: Metallophos STPPase_N
Other DBs
NCBI-GeneID: 5499
NCBI-ProteinID: NP_002699
OMIM: 176875
HGNC: 9281
Ensembl: ENSG00000172531
UniProt: P62136
Structure
LinkDB
Position
11:complement(67398183..67401858)
AA seq 330 aa
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK
NT seq 993 nt   +upstreamnt  +downstreamnt
atgtccgacagcgagaagctcaacctggactcgatcatcgggcgcctgctggaagtgcag
ggctcgcggcctggcaagaatgtacagctgacagagaacgagatccgcggtctgtgcctg
aaatcccgggagatttttctgagccagcccattcttctggagctggaggcacccctcaag
atctgcggtgacatacacggccagtactacgaccttctgcgactatttgagtatggcggt
ttccctcccgagagcaactacctctttctgggggactatgtggacaggggcaagcagtcc
ttggagaccatctgcctgctgctggcctataagatcaagtaccccgagaacttcttcctg
ctccgtgggaaccacgagtgtgccagcatcaaccgcatctatggtttctacgatgagtgc
aagagacgctacaacatcaaactgtggaaaaccttcactgactgcttcaactgcctgccc
atcgcggccatagtggacgaaaagatcttctgctgccacggaggcctgtccccggacctg
cagtctatggagcagattcggcggatcatgcggcccacagatgtgcctgaccagggcctg
ctgtgtgacctgctgtggtctgaccctgacaaggacgtgcagggctggggcgagaacgac
cgtggcgtctcttttacctttggagccgaggtggtggccaagttcctccacaagcacgac
ttggacctcatctgccgagcacaccaggtggtagaagacggctacgagttctttgccaag
cggcagctggtgacacttttctcagctcccaactactgtggcgagtttgacaatgctggc
gccatgatgagtgtggacgagaccctcatgtgctctttccagatcctcaagcccgccgac
aagaacaaggggaagtacgggcagttcagtggcctgaaccctggaggccgacccatcacc
ccaccccgcaattccgccaaagccaagaaatag

KEGG   Homo sapiens (human): 5500
Entry
5500              CDS       T01001                                 
Symbol
PPP1CB, HEL-S-80p, MP, NSLH2, PP-1B, PP1B, PP1beta, PP1c, PPP1CD, PPP1beta
Name
(RefSeq) protein phosphatase 1 catalytic subunit beta
  KO
K06269  serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04114  Oocyte meiosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04611  Platelet activation
hsa04720  Long-term potentiation
hsa04728  Dopaminergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04931  Insulin resistance
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05168  Herpes simplex virus 1 infection
hsa05205  Proteoglycans in cancer
hsa05415  Diabetic cardiomyopathy
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06515  Regulation of kinetochore-microtubule interactions
nt06526  MAPK signaling
  Element
N00572  HSV ICP34.5 to PKR-eIF2alpha signaling pathway
N01531  CENPE interaction with NDC80 complex
N01536  Dephosphorylation of kinetochore
N01598  Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Disease
H00523  Noonan syndrome and related disorders
H02191  Noonan-like syndrome with loose anagen hair
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    5500 (PPP1CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    5500 (PPP1CB)
   04024 cAMP signaling pathway
    5500 (PPP1CB)
   04022 cGMP-PKG signaling pathway
    5500 (PPP1CB)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    5500 (PPP1CB)
   04218 Cellular senescence
    5500 (PPP1CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5500 (PPP1CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5500 (PPP1CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5500 (PPP1CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5500 (PPP1CB)
   04921 Oxytocin signaling pathway
    5500 (PPP1CB)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5500 (PPP1CB)
   04270 Vascular smooth muscle contraction
    5500 (PPP1CB)
  09156 Nervous system
   04728 Dopaminergic synapse
    5500 (PPP1CB)
   04720 Long-term potentiation
    5500 (PPP1CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5500 (PPP1CB)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    5500 (PPP1CB)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    5500 (PPP1CB)
  09165 Substance dependence
   05031 Amphetamine addiction
    5500 (PPP1CB)
   05034 Alcoholism
    5500 (PPP1CB)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    5500 (PPP1CB)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5500 (PPP1CB)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5500 (PPP1CB)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    5500 (PPP1CB)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5500 (PPP1CB)
   03041 Spliceosome [BR:hsa03041]
    5500 (PPP1CB)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5500 (PPP1CB)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     5500 (PPP1CB)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     5500 (PPP1CB)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     5500 (PPP1CB)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    5500 (PPP1CB)
SSDB
Motif
Pfam: Metallophos STPPase_N
Other DBs
NCBI-GeneID: 5500
NCBI-ProteinID: NP_002700
OMIM: 600590
HGNC: 9282
Ensembl: ENSG00000213639
UniProt: P62140 V9HW04
LinkDB
Position
2:28751604..28802940
AA seq 327 aa
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKI
CGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
RGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQ
SMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDL
DLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
KAKYQYGGLNSGRPVTPPRTANPPKKR
NT seq 984 nt   +upstreamnt  +downstreamnt
atggcggacggggagctgaacgtggacagcctcatcacccggctgctggaggtacgagga
tgtcgtccaggaaagattgtgcagatgactgaagcagaagttcgaggcttatgtatcaag
tctcgggagatctttctcagccagcctattcttttggaattggaagcaccgctgaaaatt
tgtggagatattcatggacaatatacagatttactgagattatttgaatatggaggtttc
ccaccagaagccaactatcttttcttaggagattatgtggacagaggaaagcagtctttg
gaaaccatttgtttgctattggcttataaaatcaaatatccagagaacttctttctctta
agaggaaaccatgagtgtgctagcatcaatcgcatttatggattctatgatgaatgcaaa
cgaagatttaatattaaattgtggaagaccttcactgattgttttaactgtctgcctata
gcagccattgtggatgagaagatcttctgttgtcatggaggattgtcaccagacctgcaa
tctatggagcagattcggagaattatgagacctactgatgtccctgatacaggtttgctc
tgtgatttgctatggtctgatccagataaggatgtgcaaggctggggagaaaatgatcgt
ggtgtttcctttacttttggagctgatgtagtcagtaaatttctgaatcgtcatgattta
gatttgatttgtcgagctcatcaggtggtggaagatggatatgaattttttgctaaacga
cagttggtaaccttattttcagccccaaattactgtggcgagtttgataatgctggtgga
atgatgagtgtggatgaaactttgatgtgttcatttcagatattgaaaccatctgaaaag
aaagctaaataccagtatggtggactgaattctggacgtcctgtcactccacctcgaaca
gctaatccgccgaagaaaaggtga

KEGG   Homo sapiens (human): 5501
Entry
5501              CDS       T01001                                 
Symbol
PPP1CC, PP-1G, PP1C, PPP1G
Name
(RefSeq) protein phosphatase 1 catalytic subunit gamma
  KO
K06269  serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04114  Oocyte meiosis
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04390  Hippo signaling pathway
hsa04510  Focal adhesion
hsa04611  Platelet activation
hsa04720  Long-term potentiation
hsa04728  Dopaminergic synapse
hsa04750  Inflammatory mediator regulation of TRP channels
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04921  Oxytocin signaling pathway
hsa04931  Insulin resistance
hsa05031  Amphetamine addiction
hsa05034  Alcoholism
hsa05168  Herpes simplex virus 1 infection
hsa05205  Proteoglycans in cancer
hsa05415  Diabetic cardiomyopathy
Network
nt06168  Herpes simplex virus 1 (HSV-1)
nt06515  Regulation of kinetochore-microtubule interactions
nt06526  MAPK signaling
  Element
N00572  HSV ICP34.5 to PKR-eIF2alpha signaling pathway
N01531  CENPE interaction with NDC80 complex
N01536  Dephosphorylation of kinetochore
N01598  Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    5501 (PPP1CC)
 09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    5501 (PPP1CC)
   04024 cAMP signaling pathway
    5501 (PPP1CC)
   04022 cGMP-PKG signaling pathway
    5501 (PPP1CC)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    5501 (PPP1CC)
   04218 Cellular senescence
    5501 (PPP1CC)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    5501 (PPP1CC)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    5501 (PPP1CC)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    5501 (PPP1CC)
  09152 Endocrine system
   04910 Insulin signaling pathway
    5501 (PPP1CC)
   04921 Oxytocin signaling pathway
    5501 (PPP1CC)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    5501 (PPP1CC)
   04270 Vascular smooth muscle contraction
    5501 (PPP1CC)
  09156 Nervous system
   04728 Dopaminergic synapse
    5501 (PPP1CC)
   04720 Long-term potentiation
    5501 (PPP1CC)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5501 (PPP1CC)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    5501 (PPP1CC)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    5501 (PPP1CC)
  09165 Substance dependence
   05031 Amphetamine addiction
    5501 (PPP1CC)
   05034 Alcoholism
    5501 (PPP1CC)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    5501 (PPP1CC)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    5501 (PPP1CC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    5501 (PPP1CC)
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    5501 (PPP1CC)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5501 (PPP1CC)
   03041 Spliceosome [BR:hsa03041]
    5501 (PPP1CC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.16  protein-serine/threonine phosphatase
     5501 (PPP1CC)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    Catalytic subunits
     5501 (PPP1CC)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     5501 (PPP1CC)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     5501 (PPP1CC)
Spliceosome [BR:hsa03041]
 Other splicing related proteins
  Spliceosome associated proteins (SAPs)
   Other SAPs
    5501 (PPP1CC)
SSDB
Motif
Pfam: Metallophos STPPase_N
Other DBs
NCBI-GeneID: 5501
NCBI-ProteinID: NP_002701
OMIM: 176914
HGNC: 9283
Ensembl: ENSG00000186298
UniProt: P36873
Structure
LinkDB
Position
12:complement(110708376..110742891)
AA seq 323 aa
MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAE
KKKPNATRPVTPPRGMITKQAKK
NT seq 972 nt   +upstreamnt  +downstreamnt
atggcggatttagataaactcaacatcgacagcattatccaacggctgctggaagtgaga
gggtccaagcctggtaagaatgtccagcttcaggagaatgaaatcagaggactgtgctta
aagtctcgtgaaatctttctcagtcagcctatcctactagaacttgaagcaccactcaaa
atatgtggtgacatccatggacaatactatgatttgctgcgactttttgagtacggtggt
ttcccaccagaaagcaactacctgtttcttggggactatgtggacaggggaaagcagtca
ttggagacgatctgcctcttactggcctacaaaataaaatatcctgagaatttttttctt
ctcagagggaaccatgaatgtgccagcatcaacagaatttatggattttatgatgaatgt
aaaagaagatacaacattaaactatggaaaactttcacagactgttttaactgtttaccg
atagcagccatcgtggatgagaagatattctgctgtcatggaggtttatcaccagatctt
caatctatggagcagattcggcgaattatgcgaccaactgatgtaccagatcaaggtctt
ctttgtgatcttttgtggtctgaccccgataaagatgtcttaggctggggtgaaaatgac
agaggagtgtccttcacatttggtgcagaagtggttgcaaaatttctccataagcatgat
ttggatcttatatgtagagcccatcaggtggttgaagatggatatgaattttttgcaaag
aggcagttggtcactctgttttctgcgcccaattattgcggagagtttgacaatgcaggt
gccatgatgagtgtggatgaaacactaatgtgttcttttcagattttaaagcctgcagag
aaaaagaagccaaatgccacgagacctgtaacgcctccaaggggtatgatcacaaagcaa
gcaaagaaatag

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