KEGG   Homo sapiens (human): 22900
Entry
22900             CDS       T01001                                 
Symbol
CARD8, CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN
Name
(RefSeq) caspase recruitment domain family member 8
  KO
K12801  caspase recruitment domain-containing protein 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04621  NOD-like receptor signaling pathway
Network
nt06521  NLR signaling
  Element
N01568  Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition
Disease
H01227  Inflammatory bowel disease (IBD)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    22900 (CARD8)
SSDB
Motif
Pfam: FIIND CARD
Other DBs
NCBI-GeneID: 22900
NCBI-ProteinID: NP_001171829
OMIM: 609051
HGNC: 17057
Ensembl: ENSG00000105483
UniProt: Q9Y2G2
Structure
LinkDB
Position
19:complement(48179825..48255946)
AA seq 537 aa
MEKKECPEKSSSSEEELPRRDSGSSRNIDASKLIRLQGSRKLLVDNSIRELQYTKTGIFF
QAEACVTNDTVYRELPCVSETLCDISHFFQEDDETEAEPLLFRAVPECQLSGGDIPSVSE
EQESSEGQDSGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRY
SVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAE
PEEAVAEIHLPHFISLQAGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMG
ILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQ
TSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITE
KRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEV
LTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL
NT seq 1614 nt   +upstreamnt  +downstreamnt
atggaaaaaaaggagtgtccagaaaagagtagcagcagtgaggaagagctgccgagacgg
gacagtggatccagtaggaacatagatgcatccaaactcattagactacaaggatcacgg
aaactgttggttgacaatagcatacgggaactgcaatacacaaaaactggaatttttttt
caggctgaggcctgtgtgacaaatgatacggtatacagggagctaccctgtgtttctgag
accctttgtgacatctcacattttttccaagaagatgatgagacagaggcagagccatta
ttgttccgtgctgttcctgagtgtcaactatctgggggggacattcccagtgtatcagaa
gagcaggaatcttcagagggacaagattcaggagacatttgctcagaagagaatcaaata
gtttcctcttatgcttctaaagtctgttttgagatcgaagaagattataaaaatcgtcag
tttctggggcctgaaggaaatgtggatgttgagttgattgataagagcacaaacagatac
agcgtttggttccccactgctggctggtatctgtggtcagccacaggcctcggcttcctg
gtaagggatgaggtcacagtgacgattgcgtttggttcctggagtcagcacctggccctg
gacctgcagcaccatgaacagtggctggtgggcggccccttgtttgatgtcactgcagag
ccagaggaggctgtcgccgaaatccacctcccccacttcatctccctccaagcaggtgag
gtggacgtctcctggtttctcgttgcccattttaagaatgaagggatggtcctggagcat
ccagcccgggtggagcctttctatgctgtcctggaaagccccagcttctctctgatgggc
atcctgctgcggatcgccagtgggactcgcctctccatccccatcacttccaacacattg
atctattatcacccccaccccgaagatattaagttccacttgtaccttgtccccagcgac
gccttgctaacaaaggcgatagatgatgaggaagatcgcttccatggtgtgcgcctgcag
acttcgcccccaatggaacccctgaactttggttccagttatattgtgtctaattctgct
aacctgaaagtaatgcccaaggagttgaaattgtcctacaggagccctggagaaattcag
cacttctcaaaattctatgctgggcagatgaaggaacccattcaacttgagattactgaa
aaaagacatgggactttggtgtgggatactgaggtgaagccagtggatctccagcttgta
gctgcatcagcccctcctcctttctcaggtgcagcctttgtgaaggagaaccaccggcaa
ctccaagccaggatgggggacctgaaaggggtgctcgatgatctccaagacaatgaggtt
cttactgagaatgagaaggagctggtggagcaggaaaagacacggcagagcaagaatgag
gccttgctgagcatggtggagaagaaaggggacctggccctggacgtgctcttcagaagc
attagtgaaagggacccttacctcgtgtcctatcttagacagcagaatttgtaa

KEGG   Homo sapiens (human): 63940
Entry
63940             CDS       T01001                                 
Symbol
GPSM3, AGS4, C6orf9, G18, G18.1a, G18.1b, G18.2, NG1
Name
(RefSeq) G protein signaling modulator 3
  KO
K15838  G-protein signaling modulator 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04621  NOD-like receptor signaling pathway
Network
nt06521  NLR signaling
  Element
N01568  Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    63940 (GPSM3)
SSDB
Motif
Pfam: GoLoco
Other DBs
NCBI-GeneID: 63940
NCBI-ProteinID: NP_001263430
OMIM: 618558
HGNC: 13945
Ensembl: ENSG00000213654
UniProt: Q9Y4H4 A0A024RCP6
LinkDB
Position
6:complement(32190766..32195523)
AA seq 160 aa
MEAERPQEEEDGEQGPPQDEEGWPPPNSTTRPWRSAPPSPPPPGTRHTALGPRSASLLSL
QTELLLDLVAEAQSRRLEEQRATFYTPQNPSSLAPAPLRPLEDREQLYSTILSHQCQRME
AQRSEPPLPPGGQELLELLLRVQGGGRMEEQRSRPPTHTC
NT seq 483 nt   +upstreamnt  +downstreamnt
atggaggctgagagaccccaggaagaagaggatggtgagcagggcccccctcaggatgag
gaaggctggccccctccaaactccaccactcggccttggcgatctgctcctccatcccct
cctcctccagggacccgccacacagccctgggaccccgctcggcctccctgctctccctg
cagactgaactccttctggacctggtggctgaagcccagtcccgccgcctggaggagcag
agggccaccttctacaccccccaaaacccctcaagcctagcccctgccccactccgtcct
ctcgaggacagagaacagctttacagcactatcctcagtcaccagtgccagcggatggaa
gcccagcggtcagagcctcccctccctccaggggggcaagagctcctggagttgctgctg
agagttcagggtgggggtcgaatggaggagcaaaggtcccggccccccacacacacctgc
tga

KEGG   Homo sapiens (human): 345611
Entry
345611            CDS       T01001                                 
Symbol
IRGM, IBD19, IFI1, IRGM1, LRG-47, LRG47
Name
(RefSeq) immunity related GTPase M
  KO
K14139  immunity-related GTPase family M protein [EC:3.6.5.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04621  NOD-like receptor signaling pathway
hsa05145  Toxoplasmosis
Network
nt06521  NLR signaling
  Element
N01568  Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition
Disease
H00286  Crohn disease
H00342  Tuberculosis
H01227  Inflammatory bowel disease (IBD)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    345611 (IRGM)
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    345611 (IRGM)
SSDB
Motif
Pfam: IIGP LYTB Sigma54_activ_2 RsgA_GTPase SRP54 Dynamin_N
Other DBs
NCBI-GeneID: 345611
NCBI-ProteinID: NP_001139277
OMIM: 608212
HGNC: 29597
Ensembl: ENSG00000237693
UniProt: A1A4Y4
LinkDB
Position
5:150846521..150902402
AA seq 181 aa
MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEG
KASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVAS
AQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERVCE
Y
NT seq 546 nt   +upstreamnt  +downstreamnt
atggaagccatgaatgttgagaaagcctcagcagatgggaacttgccagaggtgatctct
aacatcaaggagactctgaagatagtgtccaggacaccagttaacatcactatggcaggg
gactctggcaatgggatgtccaccttcatcagtgcccttcgaaacacaggacatgagggt
aaggcctcacctcctactgagctggtaaaagctacccaaagatgtgcctcctatttctct
tcccacttttcaaatgtggtgttgtgggacctgcctggcacagggtctgccaccacaacc
ctggagaactacctgatggaaatgcagttcaaccggtatgacttcatcatggttgcatct
gcacaattcagcatgaatcatgtgatgcttgccaaaaccgctgaggacatgggaaagaag
ttctacattgtctggaccaagctagacatggacctcagcacaggtgccctcccagaagtg
cagctactgcagatcagagaaaatgtcctggaaaatctccagaaggagcgggtatgtgaa
tactaa

KEGG   COMPOUND: C00533
Entry
C00533                      Compound                               
Name
Nitric oxide;
NO;
Nitrogen monoxide
Formula
NO
Exact mass
29.998
Mol weight
30.0061
Structure
Remark
Same as: D00074
Reaction
R00111 R00280 R00294 R00557 R00783 R00784 R00785 R02492
R05724 R05725 R09445 R09446 R09751 R09799 R09808 R09809
R09996 R10106 R10108 R10165 R11711 R11713
Pathway
map00330  Arginine and proline metabolism
map00910  Nitrogen metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map02020  Two-component system
map04022  cGMP-PKG signaling pathway
map04066  HIF-1 signaling pathway
map04071  Sphingolipid signaling pathway
map04151  PI3K-Akt signaling pathway
map04270  Vascular smooth muscle contraction
map04370  VEGF signaling pathway
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04621  NOD-like receptor signaling pathway
map04626  Plant-pathogen interaction
map04713  Circadian entrainment
map04730  Long-term depression
map04915  Estrogen signaling pathway
map04921  Oxytocin signaling pathway
map04924  Renin secretion
map04926  Relaxin signaling pathway
map04931  Insulin resistance
map04940  Type I diabetes mellitus
map04970  Salivary secretion
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05140  Leishmaniasis
map05142  Chagas disease
map05143  African trypanosomiasis
map05144  Malaria
map05146  Amoebiasis
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05225  Hepatocellular carcinoma
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05415  Diabetic cardiomyopathy
map05418  Fluid shear stress and atherosclerosis
Module
M00529  Denitrification, nitrate => nitrogen
M00973  Anammox, nitrite + ammonia => nitrogen
Network
nt06226  KEAP1-NRF2 signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06463  Parkinson disease
nt06521  NLR signaling
Enzyme
1.7.1.14        1.7.2.1         1.7.2.5         1.7.2.7         
1.7.2.9         1.7.5.2         1.7.6.1         1.14.12.17      
1.14.13.39      1.14.14.47
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R07 OTHER RESPIRATORY SYSTEM PRODUCTS
   R07A OTHER RESPIRATORY SYSTEM PRODUCTS
    R07AX Other respiratory system products
     R07AX01 Nitric oxide
      D00074  Nitric oxide (JAN/USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D00074  Nitric oxide (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00074
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00074
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00074
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00074
Other DBs
CAS: 10102-43-9
PubChem: 3815
ChEBI: 16480
3DMET: B00122
NIKKAJI: J161.349I
LinkDB
KCF data

ATOM        2
            1   O3a O    21.4046  -16.1648
            2   N2a N    22.8046  -16.1648 #^
BOND        1
            1     1   2 2

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