| Entry |
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| Name |
Dasatinib laurylsulfate (USAN) |
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| Formula |
C22H26ClN7O2S. C12H26O4S
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| Exact mass |
753.3109
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| Mol weight |
754.41
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| Structure |
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| Class |
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| Remark |
| Product (DG00714): | D03658<JP> D06414<JP/US> |
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| Efficacy |
Antineoplastic, Tyrosine kinase inhibitor |
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| Target |
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| Metabolism |
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| Interaction |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EA BCR-ABL tyrosine kinase inhibitors
L01EA02 Dasatinib
D12609 Dasatinib laurylsulfate (USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG03161 BCR-ABL inhibitor
DG00714 Dasatinib
D12609 Dasatinib laurylsulfate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00714 Dasatinib
D12609 Dasatinib laurylsulfate
DG03306 FMO substrate
DG02950 FMO3 substrate
DG00714 Dasatinib
D12609 Dasatinib laurylsulfate
DG02924 UGT substrate
DG00714 Dasatinib
D12609 Dasatinib laurylsulfate
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
PDGFR family
PDGFRB
D12609 Dasatinib laurylsulfate (USAN)
KIT (CD117)
D12609 Dasatinib laurylsulfate (USAN)
EPH family
EPHA2
D12609 Dasatinib laurylsulfate (USAN)
Non-receptor tyrosine kinases
SRC family
SRC
D12609 Dasatinib laurylsulfate (USAN)
FYN
D12609 Dasatinib laurylsulfate (USAN)
LCK
D12609 Dasatinib laurylsulfate (USAN)
YES1
D12609 Dasatinib laurylsulfate (USAN)
ABL family
BCR-ABL [HSA_VAR:25v1]
D12609 Dasatinib laurylsulfate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D12609
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
DG03161 BCR-ABL inhibitor
DG00714 Dasatinib
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00714 Dasatinib
DG03306 FMO substrate
DG02950 FMO3 substrate
DG00714 Dasatinib
DG02924 UGT substrate
DG00714 Dasatinib
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 50
1 C8y C 19.1445 -15.7083
2 N5x N 19.1445 -17.1109
3 C8y C 20.4068 -17.8121
4 N5x N 21.5990 -17.1109
5 C8y C 21.5990 -15.7083
6 C8x C 20.4068 -15.0071
7 N1b N 17.9524 -15.0071
8 N1y N 22.8612 -15.0071
9 C1a C 20.4068 -19.2147
10 C1x C 24.0534 -15.7083
11 C1x C 25.2455 -15.0071
12 N1y N 25.2455 -13.6045
13 C1x C 24.0534 -12.9033
14 C1x C 22.8612 -13.6045
15 C8y C 16.7602 -15.7083
16 S2x S 15.6382 -14.8668
17 C8y C 14.5162 -15.6382
18 C8x C 14.9369 -16.9706
19 N5x N 16.2694 -16.9706
20 C5a C 13.3240 -15.0071
21 N1b N 12.1319 -15.7083
22 O5a O 13.2539 -13.5344
23 C8y C 10.8696 -15.0071
24 C8y C 10.8696 -13.5344
25 C8x C 9.6073 -12.8332
26 C8x C 8.4152 -13.6045
27 C8x C 8.4152 -15.0071
28 C8y C 9.6073 -15.7083
29 X Cl 12.0618 -12.8332
30 C1a C 9.6073 -17.0407
31 C1b C 26.5078 -12.9033
32 C1b C 27.7000 -13.6045
33 O1a O 28.8921 -12.9033
34 C1b C 42.9801 -17.3281
35 C1b C 41.7874 -18.0297
36 C1b C 40.5947 -17.3281
37 C1b C 39.3319 -18.0297
38 C1b C 38.1392 -17.3281
39 C1b C 36.9465 -18.0297
40 C1b C 35.7539 -17.3281
41 C1b C 34.5612 -18.0297
42 C1b C 33.2984 -17.3281
43 C1b C 32.1057 -18.0297
44 C1b C 30.9130 -17.3281
45 O2a O 29.7203 -18.0297
46 C1a C 44.2429 -18.0297
47 S4a S 28.3172 -18.0297
48 O1d O 26.9140 -18.0297
49 O1d O 28.3172 -16.6265
50 O1d O 28.3172 -19.4328
BOND 52
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 5 8 1
9 3 9 1
10 8 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 13 14 1
15 8 14 1
16 7 15 1
17 15 16 1
18 16 17 1
19 17 18 2
20 18 19 1
21 15 19 2
22 17 20 1
23 20 21 1
24 20 22 2
25 21 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 26 27 1
30 27 28 2
31 23 28 1
32 24 29 1
33 28 30 1
34 12 31 1
35 31 32 1
36 32 33 1
37 34 35 1
38 35 36 1
39 36 37 1
40 37 38 1
41 38 39 1
42 39 40 1
43 40 41 1
44 41 42 1
45 42 43 1
46 43 44 1
47 44 45 1
48 34 46 1
49 45 47 1
50 47 48 1
51 47 49 2
52 47 50 2
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