Homo sapiens (human): 4157 Help Entry 4157              CDS       T01001                                  Symbol MC1R, CMM5, MSH-R, SHEP2 Name (RefSeq) melanocortin 1 receptor   KO K04199   melanocortin 1 receptor Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction hsa04916   Melanogenesis Disease H00038   Melanoma H00168   Oculocutaneous albinism Drug target Afamelanotide (DG02991):  D10511 D11334<US> Bremelanotide (DG03063):  D06569 D11629<US> Dersimelagon (DG03164):  D12147 D12148 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     4157 (MC1R)  09150 Organismal Systems   09152 Endocrine system    04916 Melanogenesis     4157 (MC1R)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     4157 (MC1R) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Melanocortin     4157 (MC1R) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7tm_4 7TM_GPCR_Srsx 7TM_GPCR_Srx Pox_A14 Motif Other DBs NCBI-GeneID:  4157 NCBI-ProteinID:  NP_002377 OMIM:  155555 HGNC:  6929 Ensembl:  ENSG00000258839 UniProt:  Q01726 Q1JUL4 Structure PDB LinkDB All DBs Position 16:89918862..89920972 Genome browser AA seq 317 aa AA seqDB search MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF HSQELRRTLKEVLTCSW NT seq 954 nt NT seq  +upstreamnt  +downstreamnt atggctgtgcagggatcccagagaagacttctgggctccctcaactccacccccacagcc atcccccagctggggctggctgccaaccagacaggagcccggtgcctggaggtgtccatc tctgacgggctcttcctcagcctggggctggtgagcttggtggagaacgcgctggtggtg gccaccatcgccaagaaccggaacctgcactcacccatgtactgcttcatctgctgcctg gccttgtcggacctgctggtgagcgggagcaacgtgctggagacggccgtcatcctcctg ctggaggccggtgcactggtggcccgggctgcggtgctgcagcagctggacaatgtcatt gacgtgatcacctgcagctccatgctgtccagcctctgcttcctgggcgccatcgccgtg gaccgctacatctccatcttctacgcactgcgctaccacagcatcgtgaccctgccgcgg gcgcggcgagccgttgcggccatctgggtggccagtgtcgtcttcagcacgctcttcatc gcctactacgaccacgtggccgtcctgctgtgcctcgtggtcttcttcctggctatgctg gtgctcatggccgtgctgtacgtccacatgctggcccgggcctgccagcacgcccagggc atcgcccggctccacaagaggcagcgcccggtccaccagggctttggccttaaaggcgct gtcaccctcaccatcctgctgggcattttcttcctctgctggggccccttcttcctgcat ctcacactcatcgtcctctgccccgagcaccccacgtgcggctgcatcttcaagaacttc aacctctttctcgccctcatcatctgcaatgccatcatcgaccccctcatctacgccttc cacagccaggagctccgcaggacgctcaaggaggtgctgacatgctcctggtga

Homo sapiens (human): 4158 Help Entry 4158              CDS       T01001                                  Symbol MC2R, ACTHR Name (RefSeq) melanocortin 2 receptor   KO K04200   melanocortin 2 receptor Organism hsa  Homo sapiens (human) Pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04925   Aldosterone synthesis and secretion hsa04927   Cortisol synthesis and secretion hsa04934   Cushing syndrome Network nt06310  CRH-ACTH-cortisol signaling nt06360  Cushing syndrome   Element N00297   ACTH-cortisol signaling pathway N00298   CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway Disease H00033   Adrenal carcinoma H00256   Familial glucocorticoid deficiency H02049   Bilateral macronodular adrenal hyperplasia Drug target Alsactide:  D07417 Corticotropin (DG00492):  D00146<US> D03593 D06544 Giractide (DG01344):  D09801 D09937 Seractide acetate:  D05827 Tetracosactide (DG00493):  D00284<US> D02105<JP> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04024 cAMP signaling pathway     4158 (MC2R)   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     4158 (MC2R)  09150 Organismal Systems   09152 Endocrine system    04925 Aldosterone synthesis and secretion     4158 (MC2R)    04927 Cortisol synthesis and secretion     4158 (MC2R)  09160 Human Diseases   09167 Endocrine and metabolic disease    04934 Cushing syndrome     4158 (MC2R)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     4158 (MC2R) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Melanocortin     4158 (MC2R) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 Motif Other DBs NCBI-GeneID:  4158 NCBI-ProteinID:  NP_000520 OMIM:  607397 HGNC:  6930 Ensembl:  ENSG00000185231 UniProt:  Q01718 Structure PDB LinkDB All DBs Position 18:complement(13882044..13915707) Genome browser AA seq 297 aa AA seqDB search MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMY FFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFS LSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTS LFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVL LMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW NT seq 894 nt NT seq  +upstreamnt  +downstreamnt atgaagcacattatcaactcgtatgaaaacatcaacaacacagcaagaaataattccgac tgtcctcgtgtggttttgccggaggagatatttttcacaatttccattgttggagttttg gagaatctgatcgtcctgctggctgtgttcaagaataagaatctccaggcacccatgtac tttttcatctgtagcttggccatatctgatatgctgggcagcctatataagatcttggaa aatatcctgatcatattgagaaacatgggctatctcaagccacgtggcagttttgaaacc acagccgatgacatcatcgactccctgtttgtcctctccctgcttggctccatcttcagc ctgtctgtgattgctgcggaccgctacatcaccatcttccacgcactgcggtaccacagc atcgtgaccatgcgccgcactgtggtggtgcttacggtcatctggacgttctgcacgggg actggcatcaccatggtgatcttctcccatcatgtgcccacagtgatcaccttcacgtcg ctgttcccgctgatgctggtcttcatcctgtgcctctatgtgcacatgttcctgctggct cgatcccacaccaggaagatctccaccctccccagagccaacatgaaaggggccatcaca ctgaccatcctgctcggggtcttcatcttctgctgggccccctttgtgcttcatgtcctc ttgatgacattctgcccaagtaacccctactgcgcctgctacatgtctctcttccaggtg aacggcatgttgatcatgtgcaatgccgtcattgaccccttcatatatgccttccggagc ccagagctcagggacgcattcaaaaagatgatcttctgcagcaggtactggtag

Homo sapiens (human): 4159 Help Entry 4159              CDS       T01001                                  Symbol MC3R, BMIQ9, MC3, MC3-R, OB20, OQTL Name (RefSeq) melanocortin 3 receptor   KO K04201   melanocortin 3 receptor Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction Disease H02106   Genetic obesity Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     4159 (MC3R)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     4159 (MC3R) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Melanocortin     4159 (MC3R) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7tm_4 7TM_GPCR_Srsx Motif Other DBs NCBI-GeneID:  4159 NCBI-ProteinID:  NP_063941 OMIM:  155540 HGNC:  6931 Ensembl:  ENSG00000124089 UniProt:  P41968 Structure PDB LinkDB All DBs Position 20:56248732..56249815 Genome browser AA seq 323 aa AA seqDB search MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVI LAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIF DSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFI VYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKG AVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYA FRSLELRNTFREILCGCNGMNLG NT seq 972 nt NT seq  +upstreamnt  +downstreamnt atgaatgcttcgtgctgcctgccctctgttcagccaacactgcctaatggctcggagcac ctccaagcccctttcttcagcaaccagagcagcagcgccttctgtgagcaggtcttcatc aagcccgaggttttcctgtctctgggcatcgtcagtctgctggaaaacatcctggttatc ctggccgtggtcaggaacggcaacctgcactccccgatgtacttctttctctgcagcctg gcggtggccgacatgctggtaagtgtgtccaatgccctggagaccatcatgatcgccatc gtccacagcgactacctgaccttcgaggaccagtttatccagcacatggacaacatcttc gactccatgatctgcatctccctggtggcctccatctgcaacctcctggccatcgccgtc gacaggtacgtcaccatcttttacgcgctccgctaccacagcatcatgaccgtgaggaag gccctcaccttgatcgtggccatctgggtctgctgcggcgtctgtggcgtggtgttcatc gtctactcggagagcaaaatggtcattgtgtgcctcatcaccatgttcttcgccatgatg ctcctcatgggcaccctctacgtgcacatgttcctctttgcgcggctgcacgtcaagcgc atagcagcactgccacctgccgacggggtggccccacagcaacactcatgcatgaagggg gcagtcaccatcaccattctcctgggcgtgttcatcttctgctgggcccccttcttcctc cacctggtcctcatcatcacctgccccaccaacccctactgcatctgctacactgcccac ttcaacacctacctggtcctcatcatgtgcaactccgtcatcgacccactcatctacgct ttccggagcctggaattgcgcaacacctttagggagattctctgtggctgcaacggcatg aacttgggatag

Homo sapiens (human): 4160 Help Entry 4160              CDS       T01001                                  Symbol MC4R, BMIQ20 Name (RefSeq) melanocortin 4 receptor   KO K04202   melanocortin 4 receptor Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction Disease H02106   Genetic obesity Drug target Bremelanotide (DG03063):  D06569 D11629<US> Setmelanotide (DG03132):  D11927 D11928<US> D11929 Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     4160 (MC4R)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     4160 (MC4R) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Melanocortin     4160 (MC4R) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 Motif Other DBs NCBI-GeneID:  4160 NCBI-ProteinID:  NP_005903 OMIM:  155541 HGNC:  6932 Ensembl:  ENSG00000166603 UniProt:  P32245 Structure PDB LinkDB All DBs Position 18:complement(60371062..60372775) Genome browser AA seq 332 aa AA seqDB search MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL IYALRSQELRKTFKEIICCYPLGGLCDLSSRY NT seq 999 nt NT seq  +upstreamnt  +downstreamnt atggtgaactccacccaccgtgggatgcacacttctctgcacctctggaaccgcagcagt tacagactgcacagcaatgccagtgagtcccttggaaaaggctactctgatggagggtgc tacgagcaactttttgtctctcctgaggtgtttgtgactctgggtgtcatcagcttgttg gagaatatcttagtgattgtggcaatagccaagaacaagaatctgcattcacccatgtac tttttcatctgcagcttggctgtggctgatatgctggtgagcgtttcaaatggatcagaa accattgtcatcaccctattaaacagtacagatacggatgcacagagtttcacagtgaat attgataatgtcattgactcggtgatctgtagctccttgcttgcatccatttgcagcctg ctttcaattgcagtggacaggtactttactatcttctatgctctccagtaccataacatt atgacagttaagcgggttgggatcatcataagttgtatctgggcagcttgcacggtttca ggcattttgttcatcatttactcagatagtagtgctgtcatcatctgcctcatcaccatg ttcttcaccatgctggctctcatggcttctctctatgtccacatgttcctgatggccagg cttcacattaagaggattgctgtcctccccggcactggtgccatccgccaaggtgccaat atgaagggagcgattaccttgaccatcctgattggcgtctttgttgtctgctgggcccca ttcttcctccacttaatattctacatctcttgtcctcagaatccatattgtgtgtgcttc atgtctcactttaacttgtatctcatactgatcatgtgtaattcaatcatcgatcctctg atttatgcactccggagtcaagaactgaggaaaaccttcaaagagatcatctgttgctat cccctgggaggcctttgtgacttgtctagcagatattaa

Homo sapiens (human): 4161 Help Entry 4161              CDS       T01001                                  Symbol MC5R, MC2 Name (RefSeq) melanocortin 5 receptor   KO K04203   melanocortin 5 receptor Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     4161 (MC5R)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04030 G protein-coupled receptors [BR:hsa04030]     4161 (MC5R) G protein-coupled receptors [BR:hsa04030]  Rhodopsin family   Peptide    Melanocortin     4161 (MC5R) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  7tm_1 7tm_4 7TM_GPCR_Srsx 7TM_GPCR_Srx Motif Other DBs NCBI-GeneID:  4161 NCBI-ProteinID:  NP_005904 OMIM:  600042 HGNC:  6933 Ensembl:  ENSG00000176136 UniProt:  P33032 Structure PDB LinkDB All DBs Position 18:13824149..13827323 Genome browser AA seq 325 aa AA seqDB search MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGA IVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDS MICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILY SESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTV TMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQ EMRKTFKEIICCRGFRIACSFPRRD NT seq 978 nt NT seq  +upstreamnt  +downstreamnt atgaattcctcatttcacctgcatttcttggatctcaacctgaatgccacagagggcaac ctttcaggacccaatgtcaaaaacaagtcttcaccatgtgaagacatgggcattgctgtg gaggtgtttctcactctgggtgtcatcagcctcttggagaacatcttggtcataggggcc atagtgaagaacaaaaacctgcactcccccatgtacttcttcgtgtgcagcctggcagtg gcggacatgctggtgagcatgtccagtgcctgggagaccatcaccatctacctactcaac aacaagcacctagtgatagcagacgcctttgtgcgccacattgacaatgtgtttgactcc atgatctgcatttccgtggtggcatccatgtgcagcttactggccattgcagtggatagg tacgtcaccatcttctacgccctgcgctaccaccacatcatgacggcgaggcgctcaggg gccatcatcgccggcatctgggctttctgcacgggctgcggcattgtcttcatcctgtac tcagaatccacctacgtcatcctgtgcctcatctccatgttcttcgctatgctgttcctc ctggtgtctctgtacatacacatgttcctcctggcgcggactcacgtcaagcggatcgcg gctctgcccggggccagctctgcgcggcagaggaccagcatgcagggcgcggtcaccgtc accatgctgctgggcgtgtttaccgtgtgctgggccccgttcttccttcatctcacttta atgctttcttgccctcagaacctctactgctctcgcttcatgtctcacttcaatatgtac ctcatactcatcatgtgtaattccgtgatggaccctctcatatatgccttccgcagccaa gagatgcggaagacctttaaggagattatttgctgccgtggtttcaggatcgcctgcagc tttcccagaagggattaa

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