Homo sapiens (human): 51135
Help
Entry
51135 CDS
T01001
Symbol
IRAK4, IMD67, IPD1, IRAK-4, NY-REN-64, REN64
Name
(RefSeq) interleukin 1 receptor associated kinase 4
KO
K04733
interleukin-1 receptor-associated kinase 4 [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04620
Toll-like receptor signaling pathway
hsa04621
NOD-like receptor signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04936
Alcoholic liver disease
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05162
Measles
hsa05164
Influenza A
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06180
Pathogenic Escherichia coli
nt06182
Shigella
nt06183
Yersinia
nt06211
Other MAPK signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06517
TLR signaling
nt06526
MAPK signaling
Element
N00186
IL1-IL1R-p38 signaling pathway
N00188
IL1-IL1R-JNK signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00438
TLR2/4-MAPK signaling pathway
N00690
TLR7/9-IRF7 signaling pathway
N01543
TLR7/8/9-IRF5 signaling pathway
N01566
TLR5-NFKB signaling pathway
Disease
H00096
Defects of toll-like receptor signaling
Drug target
Emavusertib (
DG03236
):
D12411
D12412
D12532
D12533
D12538
D12539
Zimlovisertib:
D12167
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
51135 (IRAK4)
04064 NF-kappa B signaling pathway
51135 (IRAK4)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
51135 (IRAK4)
04621 NOD-like receptor signaling pathway
51135 (IRAK4)
09156 Nervous system
04722 Neurotrophin signaling pathway
51135 (IRAK4)
09160 Human Diseases
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
51135 (IRAK4)
05161 Hepatitis B
51135 (IRAK4)
05171 Coronavirus disease - COVID-19
51135 (IRAK4)
05164 Influenza A
51135 (IRAK4)
05162 Measles
51135 (IRAK4)
05168 Herpes simplex virus 1 infection
51135 (IRAK4)
05169 Epstein-Barr virus infection
51135 (IRAK4)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
51135 (IRAK4)
05132 Salmonella infection
51135 (IRAK4)
05135 Yersinia infection
51135 (IRAK4)
05133 Pertussis
51135 (IRAK4)
05152 Tuberculosis
51135 (IRAK4)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
51135 (IRAK4)
05140 Leishmaniasis
51135 (IRAK4)
05142 Chagas disease
51135 (IRAK4)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
51135 (IRAK4)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
51135 (IRAK4)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
51135 (IRAK4)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
51135 (IRAK4)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: TKL group
IRAK family
51135 (IRAK4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
Pkinase_fungal
Haspin_kinase
Death
RecA_C
Motif
Other DBs
NCBI-GeneID:
51135
NCBI-ProteinID:
NP_001107654
OMIM:
606883
HGNC:
17967
Ensembl:
ENSG00000198001
UniProt:
Q9NWZ3
Q69FE3
B4E359
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:43758951..43789541
Genome browser
AA seq
460 aa
AA seq
DB search
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
NT seq
1383 nt
NT seq
+upstream
nt +downstream
nt
atgaacaaacccataacaccatcaacatatgtgcgctgcctcaatgttggactaattagg
aagctgtcagattttattgatcctcaagaaggatggaagaagttagctgtagctattaaa
aaaccatctggtgatgatagatacaatcagtttcacataaggagatttgaagcattactt
caaactggaaaaagtcccacttctgaattactgtttgactggggcaccacaaattgcaca
gttggtgatcttgtggatcttttgatccaaaatgaattttttgctcctgcgagtcttttg
ctcccagatgctgttcccaaaactgctaatacactaccttctaaagaagctataacagtt
cagcaaaaacagatgcctttctgtgacaaagacaggacattgatgacacctgtgcagaat
cttgaacaaagctatatgccacctgactcctcaagtccagaaaataaaagtttagaagtt
agtgatacacgttttcacagtttttcattttatgaattgaagaatgtcacaaataacttt
gatgaacgacccatttctgttggtggtaataaaatgggagagggaggatttggagttgta
tataaaggctacgtaaataacacaactgtggcagtgaagaagcttgcagcaatggttgac
attactactgaagaactgaaacagcagtttgatcaagaaataaaagtaatggcaaagtgt
caacatgaaaacttagtagaactacttggtttctcaagtgatggagatgacctctgctta
gtatatgtttacatgcctaatggttcattgctagacagactctcttgcttggatggtact
ccaccactttcttggcacatgagatgcaagattgctcagggtgcagctaatggcatcaat
tttctacatgaaaatcatcatattcatagagatattaaaagtgcaaatatcttactggat
gaagcttttactgctaaaatatctgactttggccttgcacgggcttctgagaagtttgcc
cagacagtcatgactagcagaattgtgggaacaacagcttatatggcaccagaagctttg
cgtggagaaataacacccaaatctgatatttacagctttggtgtggttttactagaaata
ataactggacttccagctgtggatgaacaccgtgaacctcagttattgctagatattaaa
gaagaaattgaagatgaagaaaagacaattgaagattatattgataaaaagatgaatgat
gctgattccacttcagttgaagctatgtactctgttgctagtcaatgtctgcatgaaaag
aaaaataagagaccagacattaagaaggttcaacagctgctgcaagagatgacagcttct
taa
Homo sapiens (human): 3654
Help
Entry
3654 CDS
T01001
Symbol
IRAK1, IRAK, pelle
Name
(RefSeq) interleukin 1 receptor associated kinase 1
KO
K04730
interleukin-1 receptor-associated kinase 1 [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04010
MAPK signaling pathway
hsa04064
NF-kappa B signaling pathway
hsa04620
Toll-like receptor signaling pathway
hsa04722
Neurotrophin signaling pathway
hsa04936
Alcoholic liver disease
hsa05130
Pathogenic Escherichia coli infection
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05135
Yersinia infection
hsa05140
Leishmaniasis
hsa05142
Chagas disease
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05162
Measles
hsa05168
Herpes simplex virus 1 infection
hsa05169
Epstein-Barr virus infection
hsa05170
Human immunodeficiency virus 1 infection
hsa05171
Coronavirus disease - COVID-19
hsa05417
Lipid and atherosclerosis
Network
nt06161
Human immunodeficiency virus 1 (HIV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06168
Herpes simplex virus 1 (HSV-1)
nt06169
Measles virus (MV)
nt06180
Pathogenic Escherichia coli
nt06182
Shigella
nt06183
Yersinia
nt06211
Other MAPK signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06517
TLR signaling
nt06526
MAPK signaling
Element
N00186
IL1-IL1R-p38 signaling pathway
N00188
IL1-IL1R-JNK signaling pathway
N00435
TLR1/2/4-NFKB signaling pathway
N00438
TLR2/4-MAPK signaling pathway
N00690
TLR7/9-IRF7 signaling pathway
N01543
TLR7/8/9-IRF5 signaling pathway
N01566
TLR5-NFKB signaling pathway
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
3654 (IRAK1)
04064 NF-kappa B signaling pathway
3654 (IRAK1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
3654 (IRAK1)
09156 Nervous system
04722 Neurotrophin signaling pathway
3654 (IRAK1)
09160 Human Diseases
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
3654 (IRAK1)
05161 Hepatitis B
3654 (IRAK1)
05171 Coronavirus disease - COVID-19
3654 (IRAK1)
05162 Measles
3654 (IRAK1)
05168 Herpes simplex virus 1 infection
3654 (IRAK1)
05169 Epstein-Barr virus infection
3654 (IRAK1)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
3654 (IRAK1)
05132 Salmonella infection
3654 (IRAK1)
05135 Yersinia infection
3654 (IRAK1)
05133 Pertussis
3654 (IRAK1)
05152 Tuberculosis
3654 (IRAK1)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
3654 (IRAK1)
05140 Leishmaniasis
3654 (IRAK1)
05142 Chagas disease
3654 (IRAK1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3654 (IRAK1)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
3654 (IRAK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
3654 (IRAK1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
3654 (IRAK1)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: TKL group
IRAK family
3654 (IRAK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Death
RAMP
APH
Motif
Other DBs
NCBI-GeneID:
3654
NCBI-ProteinID:
NP_001560
OMIM:
300283
HGNC:
6112
Ensembl:
ENSG00000184216
UniProt:
P51617
Structure
PDB
PDBj
LinkDB
All DBs
Position
X:complement(154010507..154019902)
Genome browser
AA seq
712 aa
AA seq
DB search
MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCE
RSGQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTAPRPSS
IPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPAPSSTK
PGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKR
LKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRL
HCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFG
LARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAG
QRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDP
RPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPP
SPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALR
SWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQI
IINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
NT seq
2139 nt
NT seq
+upstream
nt +downstream
nt
atggccggggggccgggcccgggggagcccgcagcccccggcgcccagcacttcttgtac
gaggtgccgccctgggtcatgtgccgcttctacaaagtgatggacgccctggagcccgcc
gactggtgccagttcgccgccctgatcgtgcgcgaccagaccgagctgcggctgtgcgag
cgctccgggcagcgcacggccagcgtcctgtggccctggatcaaccgcaacgcccgtgtg
gccgacctcgtgcacatcctcacgcacctgcagctgctccgtgcgcgggacatcatcaca
gcctggcaccctcccgccccgcttccgtccccaggcaccactgccccgaggcccagcagc
atccctgcacccgccgaggccgaggcctggagcccccggaagttgccatcctcagcctcc
accttcctctccccagcttttccaggctcccagacccattcagggcctgagctcggcctg
gtcccaagccctgcttccctgtggcctccaccgccatctccagccccttcttctaccaag
ccaggcccagagagctcagtgtccctcctgcagggagcccgcccctttccgttttgctgg
cccctctgtgagatttcccggggcacccacaacttctcggaggagctcaagatcggggag
ggtggctttgggtgcgtgtaccgggcggtgatgaggaacacggtgtatgctgtgaagagg
ctgaaggagaacgctgacctggagtggactgcagtgaagcagagcttcctgaccgaggtg
gagcagctgtccaggtttcgtcacccaaacattgtggactttgctggctactgtgctcag
aacggcttctactgcctggtgtacggcttcctgcccaacggctccctggaggaccgtctc
cactgccagacccaggcctgcccacctctctcctggcctcagcgactggacatccttctg
ggtacagcccgggcaattcagtttctacatcaggacagccccagcctcatccatggagac
atcaagagttccaacgtccttctggatgagaggctgacacccaagctgggagactttggc
ctggcccggttcagccgctttgccgggtccagccccagccagagcagcatggtggcccgg
acacagacagtgcggggcaccctggcctacctgcccgaggagtacatcaagacgggaagg
ctggctgtggacacggacaccttcagctttggggtggtagtgctagagaccttggctggt
cagagggctgtgaagacgcacggtgccaggaccaagtatctgaaagacctggtggaagag
gaggctgaggaggctggagtggctttgagaagcacccagagcacactgcaagcaggtctg
gctgcagatgcctgggctgctcccatcgccatgcagatctacaagaagcacctggacccc
aggcccgggccctgcccacctgagctgggcctgggcctgggccagctggcctgctgctgc
ctgcaccgccgggccaaaaggaggcctcctatgacccaggtgtacgagaggctagagaag
ctgcaggcagtggtggcgggggtgcccgggcattcggaggccgccagctgcatcccccct
tccccgcaggagaactcctacgtgtccagcactggcagagcccacagtggggctgctcca
tggcagcccctggcagcgccatcaggagccagtgcccaggcagcagagcagctgcagaga
ggccccaaccagcccgtggagagtgacgagagcctaggcggcctctctgctgccctgcgc
tcctggcacttgactccaagctgccctctggacccagcacccctcagggaggccggctgt
cctcagggggacacggcaggagaatcgagctgggggagtggcccaggatcccggcccaca
gccgtggaaggactggcccttggcagctctgcatcatcgtcgtcagagccaccgcagatt
atcatcaaccctgcccgacagaagatggtccagaagctggccctgtacgaggatggggcc
ctggacagcctgcagctgctgtcgtccagctccctcccaggcttgggcctggaacaggac
aggcaggggcccgaagaaagtgatgaatttcagagctga
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integrated database retrieval system
