Homo sapiens (human): 5153
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Entry
5153 CDS
T01001
Symbol
PDE1B, HEL-S-79p, PDE1B1, PDES1B
Name
(RefSeq) phosphodiesterase 1B
KO
K13755
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:
3.1.4.17
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00230
Purine metabolism
hsa01100
Metabolic pathways
hsa04020
Calcium signaling pathway
hsa04740
Olfactory transduction
hsa04742
Taste transduction
hsa04924
Renin secretion
hsa05032
Morphine addiction
Drug target
Aminophylline (
DG01062
):
D00227
D05429
<JP>
D11630
<US>
Bemoradan:
D03075
Bucladesine (
DG00230
):
D01238
<JP>
D07546
Caffeine (
DG00974
):
D00528
<JP>
D01453
<JP>
D07603
<US>
Choline theophyllinate:
D02017
Diprophylline:
D00691
<JP>
Enprofylline:
D04006
Flavoxate (
DG00477
):
D00718
<JP/US>
D07961
Lenrispodun (
DG03118
):
D11883
D11884
Moxaverine (
DG00045
):
D07089
D08238
Oxagrelate:
D05278
Papaverine (
DG00043
):
D02218
<JP>
D07425
D07439
Prinoxodan:
D05612
Proxyphylline:
D01771
Theophylline (
DG01061
):
D00371
<JP/US>
D01712
D06103
D06104
Theosalicin:
D09822
Tibenelast sodium:
D06132
Trapidil:
D01220
<JP>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
5153 (PDE1B)
09150 Organismal Systems
09152 Endocrine system
04924 Renin secretion
5153 (PDE1B)
09157 Sensory system
04740 Olfactory transduction
5153 (PDE1B)
04742 Taste transduction
5153 (PDE1B)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
5153 (PDE1B)
Enzymes [BR:
hsa01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase
5153 (PDE1B)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PDEase_I
PDEase_I_N
La_HTH_kDCL
Motif
Other DBs
NCBI-GeneID:
5153
NCBI-ProteinID:
NP_000915
OMIM:
171891
HGNC:
8775
Ensembl:
ENSG00000123360
UniProt:
Q01064
Structure
PDB
PDBj
LinkDB
All DBs
Position
12:54549601..54579239
Genome browser
AA seq
536 aa
AA seq
DB search
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNL
EYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKP
KFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHAL
RTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLL
RTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSV
FRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPK
ALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQS
QIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVS
FRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
NT seq
1611 nt
NT seq
+upstream
nt +downstream
nt
atggagctgtccccccgcagtcctccggagatgctggaggagtcggattgcccgtcaccc
ctggagctgaagtcagcccccagcaagaagatgtggattaagcttcggtctctgctgcgc
tacatggtgaagcagttggagaatggggagataaacattgaggagctgaagaaaaatctg
gagtacacagcttctctgctggaagccgtctacatagatgagacacggcaaatcttggac
acggaggacgagctgcaggagctgcggtcagatgccgtgccttcggaggtgcgggactgg
ctggcctccaccttcacccagcaggcccgggccaaaggccgccgagcagaggagaagccc
aagttccgaagcattgtgcacgctgtgcaggctgggatcttcgtggaacggatgttccgg
agaacatacacctctgtgggccccacttactctactgcggttctcaactgtctcaagaac
ctggatctctggtgctttgatgtcttttccttgaaccaggcagcagatgaccatgccctg
aggaccattgtttttgagttgctgactcggcataacctcatcagccgcttcaagattccc
actgtgtttttgatgagtttcctggatgccttggagacaggctatgggaagtacaagaat
ccttaccacaaccagatccacgcagccgatgttacccagacagtccattgcttcttgctc
cgcacagggatggtgcactgcctgtcggagattgagctcctggccatcatctttgctgca
gctatccatgattatgagcacacgggcactaccaacagcttccacatccagaccaagtca
gaatgtgccatcgtgtacaatgatcgttcagtgctggagaatcaccacatcagctctgtt
ttccgattgatgcaggatgatgagatgaacattttcatcaacctcaccaaggatgagttt
gtagaactccgagccctggtcattgagatggtgttggccacagacatgtcctgccatttc
cagcaagtgaagaccatgaagacagccttgcaacagctggagaggattgacaagcccaag
gccctgtctctactgctccatgctgctgacatcagccacccaaccaagcagtggttggtc
cacagccgttggaccaaggccctcatggaggaattcttccgtcagggtgacaaggaggca
gagttgggcctgcccttttctccactctgtgaccgcacttccactctagtggcacagtct
cagatagggttcatcgacttcattgtggagcccacattctctgtgctgactgacgtggca
gagaagagtgttcagcccctggcggatgaggactccaagtctaaaaaccagcccagcttt
cagtggcgccagccctctctggatgtggaagtgggagaccccaaccctgatgtggtcagc
tttcgttccacctgggtcaagcgcattcaggagaataagcagaaatggaaggaacgggca
gcaagtggcatcaccaaccagatgtccattgacgagctgtccccctgtgaagaagaggcc
cccccatcccctgccgaagatgaacacaaccagaatgggaatctggattag
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