KEGG ORTHOLOGY: K05688

ORTHOLOGY: K05688

Entry

K05688                      KO

Symbol

PINK1

Name

PTEN induced putative kinase 1 [EC:2.7.11.1]

Pathway

map04137

Mitophagy - animal

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00057

Parkinson disease

H01600

Parkinsonian syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K05688  PINK1; PTEN induced putative kinase 1
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K05688  PINK1; PTEN induced putative kinase 1
   05014 Amyotrophic lateral sclerosis
    K05688  PINK1; PTEN induced putative kinase 1
   05022 Pathways of neurodegeneration - multiple diseases
    K05688  PINK1; PTEN induced putative kinase 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05688  PINK1; PTEN induced putative kinase 1
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05688  PINK1; PTEN induced putative kinase 1
   03029 Mitochondrial biogenesis
    K05688  PINK1; PTEN induced putative kinase 1
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K05688  PINK1; PTEN induced putative kinase 1
Protein kinases [BR:ko01001]
Serine/threonine kinases: Other
  NKF2 family
   K05688  PINK1; PTEN induced putative kinase 1
Membrane trafficking [BR:ko04131]
Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K05688  PINK1; PTEN induced putative kinase 1
Mitochondrial biogenesis [BR:ko03029]
Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    K05688  PINK1; PTEN induced putative kinase 1

Genes

HSA:	65018(PINK1)

PTR:	749028(PINK1)

PPS:	100991148(PINK1)

GGO:	101125489(PINK1)

PON:	100443445(PINK1)

PPYG:

129044859(PINK1)

NLE:	100599956(PINK1) 105740041 115835845

HMH:	116813030(PINK1)

SSYN:

129471920(PINK1)

MCC:	706037(PINK1)

MCF:	102125675(PINK1)

MTHB:

126955100

MNI:	105483085(PINK1)

CSAB:

103225450(PINK1)

CATY:

105595041(PINK1)

PANU:

101024255(PINK1)

TGE:	112606260(PINK1)

MLEU:

105532247(PINK1)

RRO:	104663205(PINK1)

RBB:	108515300(PINK1)

TFN:	117093184(PINK1)

PTEH:

111547732(PINK1)

CANG:

105506050(PINK1)

CJC:	100412264(PINK1)

SBQ:	101037834(PINK1)

CIMI:

108287839

ANAN:

105708355(PINK1)

CSYR:

103254798(PINK1)

MMUR:

105883977(PINK1)

LCAT:

123635888(PINK1)

PCOQ:

105822308(PINK1)

OGA:	100955399(PINK1)

MMU:	68943(Pink1)

MCAL:

110292810(Pink1)

MPAH:

110323093(Pink1)

MCOC:

116096899(Pink1)

ANU:	117708934(Pink1)

ASYL:

127681514(Pink1)

MUN:	110544995(Pink1)

CGE:	100757303(Pink1)

MAUA:

101830271(Pink1)

PROB:

127213306(Pink1)

PLEU:

114697193(Pink1)

MORG:

121447993(Pink1)

MFOT:

126508043

AAMP:

119816504(Pink1)

NGI:	103738564(Pink1)

HGL:	101716045(Pink1)

CPOC:

100720253(Pink1)

CCAN:

109689686(Pink1)

DORD:

105999190(Pink1)

DSP:	122115150(Pink1)

PLOP:

125354670(Pink1)

NCAR:

124983421

MMMA:

107142167(Pink1)

ITI:	101955442(Pink1)

OCU:

100350666

OPI:	101521981(PINK1)

TUP:	102494988(PINK1)

GVR:	103606177(PINK1)

CFA:	100688445(PINK1)

CLUD:

112660315(PINK1)

VVP:	112929829(PINK1)

VLG:	121497182(PINK1)

NPO:	129513725(PINK1)

AML:	100465867(PINK1)

UMR:	103666590(PINK1)

UAH:	113268560(PINK1)

UAR:	123782135(PINK1)

ELK:

111154572

LLV:

125097148

MPUF:

101682150(PINK1)

MNP:	132001698(PINK1)

MLK:	131810414(PINK1)

NVS:	122899531(PINK1)

ORO:	101381501(PINK1)

EJU:	114199039(PINK1)

ZCA:	113911064(PINK1)

MLX:	118019925(PINK1)

NSU:	110575160(PINK1)

LWW:	102739603(PINK1)

FCA:	101093033(PINK1)

PYU:	121022375(PINK1)

PCOO:

112862120(PINK1)

PBG:	122480039(PINK1)

PVIV:

125172073(PINK1)

LRUF:

124514764

LGF:	123597322(PINK1)

AJU:

106987997

PTG:	102955123(PINK1)

PPAD:

109274247(PINK1)

PUC:

125913014

PLEZ:

122226268(PINK1)

HHV:	120229775(PINK1)

BTA:	510683(PINK1)

BOM:	102277915(PINK1)

BIU:	109576174(PINK1)

BBUB:

102401425(PINK1)

BBIS:

104981228(PINK1)

CHX:	102190832(PINK1)

OAS:	101102131(PINK1)

BTAX:

128043231(PINK1)

CSUM:

138075655(PINK1)

ODA:	120855001(PINK1)

CCAD:

122426048(PINK1)

MREE:

136164672(PINK1)

OVR:	110149547(PINK1)

MBEZ:

129538611(PINK1)

SSC:	100515613(PINK1)

CFR:	102521586(PINK1)

CBAI:

105070892(PINK1)

CDK:	105088855(PINK1)

VPC:	102526322(PINK1)

BACU:

103003466(PINK1)

BMUS:

118892402(PINK1)

LVE:	103070110(PINK1)

OOR:	101287390(PINK1)

LALB:

132515152(PINK1)

DLE:	111163436(PINK1)

PCAD:

102994189(PINK1)

PSIU:

116745079(PINK1)

NASI:

112402762(PINK1)

ECB:	100071784(PINK1)

EPZ:	103541347(PINK1)

EAI:	106840050(PINK1)

MYB:	102242404(PINK1)

MYD:	102757961(PINK1)

MMYO:

118677738(PINK1)

MLF:	102433376(PINK1)

MDT:	132231575(PINK1)

MYUM:

139002952(PINK1)

PKL:	118722390(PINK1)

EFUS:

103291980(PINK1)

MNA:	107538319(PINK1)

DRO:	112298995(PINK1)

SHON:

118977860(PINK1)

AJM:	119045401(PINK1)

PDIC:

114496669(PINK1)

PHAS:

123831619(PINK1)

MMF:	118626081(PINK1)

PPAM:

129069140(PINK1)

HAI:	109395562(PINK1)

RFQ:	117026727(PINK1)

PALE:

102889368(PINK1)

PGIG:

120596250(PINK1)

PVP:	105290422(PINK1)

RAY:	107513041(PINK1)

MJV:	108398638(PINK1)

TOD:	119235159(PINK1)

SARA:

101547033(PINK1)

SFUM:

130031740(PINK1)

SETR:

126006546(PINK1)

LAV:	100671477(PINK1)

TMU:

101344541

ETF:	101644140(PINK1)

DNM:	101424899(PINK1)

MDO:	100027082(PINK1)

GAS:	123240355(PINK1)

SHR:	100928885(PINK1)

AFZ:

127555757

PCW:	110198718(PINK1)

TVP:	118835854(PINK1)

PBRV:

138154012(PINK1)

OAA:	100089816(PINK1)

TACU:

119928763(PINK1)

PCOC:

116242602(PINK1)

MGP:	100540660(PINK1)

CJO:	107323259(PINK1)

TPAI:

128085088(PINK1)

LMUT:

125703380(PINK1)

NMEL:

110408508(PINK1)

APLA:

101789396(PINK1)

ACYG:

106040125(PINK1)

CATA:

118253243(PINK1)

AFUL:

116497741(PINK1)

TGU:	100229816(PINK1)

LSR:	110472245(PINK1)

SCAN:

103824351(PINK1)

PMOA:

120499399(PINK1)

OTC:	121343974(PINK1)

PRUF:

121351377(PINK1)

ATRC:

139600785(PINK1)

GFR:	102038690(PINK1)

FAB:	101822075(PINK1)

OMA:	130261775(PINK1)

PHI:	102103989(PINK1)

PMAJ:

107213518(PINK1)

CCAE:

111938463(PINK1)

CCW:	104697553(PINK1)

CBRC:

103616201(PINK1)

ACOE:

138121418(PINK1)

ETL:	114068716(PINK1)

ZAB:	102072684(PINK1)

ZLE:	135456816(PINK1)

ACHL:

103807541(PINK1)

SVG:	106856437(PINK1)

MMEA:

130585073(PINK1)

HRT:	120762329(PINK1)

SATI:

136370784(PINK1)

CCIC:

134052843(PINK1)

FPG:	101915366(PINK1)

FCH:	102053946(PINK1)

CCRI:

104156326(PINK1)

NNT:	104402922(PINK1)

SHAB:

115617276(PINK1)

ACUN:

113487964(PINK1)

TALA:

104368887(PINK1)

ACHC:

115343106(PINK1)

HALD:

104322161(PINK1)

HLE:	104838006(PINK1)

AGEN:

126033887

HHAR:

128143670(PINK1)

GCL:

127024805

CSTI:

104551802(PINK1)

MNB:	103771143(PINK1)

DPUB:

104305900(PINK1)

PPUS:

135190420(PINK1)

AVIT:

104274450(PINK1)

BRHI:

104494534(PINK1)

EGZ:	104133158(PINK1)

NNI:	104011210(PINK1)

PCRI:

104038492(PINK1)

PCAO:

104043523(PINK1)

PADL:

103918066(PINK1)

AFOR:

103907425(PINK1)

FGA:	104070993(PINK1)

GSTE:

104257974(PINK1)

CLV:	102093865(PINK1)

MUI:	104542066(PINK1)

PGUU:

104458928(PINK1)

PLET:

104618168(PINK1)

EHS:	104507545(PINK1)

CMAC:

104484405(PINK1)

CUCA:

104060616(PINK1)

TEO:	104377089(PINK1)

BREG:

104630816(PINK1)

OHA:	104336692(PINK1)

ACAR:

104522635(PINK1)

CPEA:

104395513(PINK1)

CVF:	104290818(PINK1)

RTD:	128918291(PINK1)

CRID:

134524290(PINK1)

AAM:	106493427(PINK1)

AROW:

112966846(PINK1)

NPD:	112959558(PINK1)

TGT:	104569139(PINK1)

DNE:	112988489(PINK1)

SCAM:

104153650(PINK1)

ASN:	106723111(PINK1)

AMJ:	102574908(PINK1)

CPOO:

109314514(PINK1)

GGN:	109293562(PINK1)

PSS:	102444248(PINK1)

CMY:	102939538(PINK1)

CCAY:

125624444(PINK1)

DCC:	119845037(PINK1)

CPIC:

101943102(PINK1)

TST:	117868068(PINK1)

CABI:

116824356(PINK1)

MRV:	120387755(PINK1)

ASAO:

132764693(PINK1)

PVT:	110072691(PINK1)

SUND:

121936230(PINK1)

PBI:	103059482(PINK1)

PMUR:

107291375(PINK1)

CTIG:

120319035(PINK1)

TSR:	106547436(PINK1)

PGUT:

117669671(PINK1)

APRI:

131186951(PINK1)

PTEX:

113449768(PINK1)

NSS:	113424003(PINK1)

VKO:	123034733(PINK1)

PMUA:

114602388(PINK1)

PRAF:

128419601(PINK1)

ZVI:	118086141(PINK1)

HCG:	128338580(PINK1)

GJA:	107124402(PINK1)

STOW:

125445629(PINK1)

EMC:	129345044(PINK1)

DRE:	494085(pink1)

SRX:	107714979 107751828 107751829

SANH:

107664115 107697909

SGH:	107563139 107599510

CCAR:

109081627 109100545

CAUA:

113041193 113065696 113071119

CGIB:

127944610 128011205

PTET:

122328975(pink1)

LROH:

127154812(pink1)

OMC:	131532048(pink1)

PPRM:

120463602(pink1)

RKG:	130090592(pink1)

MAMB:

125260071(pink1)

CIDE:

127505538

CERY:

137008932(pink1)

MASI:

127418777

TROS:

130545131(pink1)

TDW:	130408976(pink1)

MANU:

129430782(pink1)

PDAB:

135775218(pink1)

IPU:

108275846

IFU:	128619217(pink1)

PHYP:

113530970(pink1)

SMEO:

124399127(pink1)

TFD:	113641891(pink1)

TVC:	132862042(pink1)

CGAR:

128509902(pink1)

NGRA:

132896632(pink1)

TRN:	134333169(pink1)

AMEX:

103044294(pink1)

CMAO:

118822289(pink1)

EEE:	113570339(pink1)

CHAR:

105912719(pink1)

SPIL:

134087580(pink1)

TRU:	101064886(pink1)

TFS:	130529773(pink1)

TNG:	GSTEN00008254G001 GSTEN00023370G001

LCO:	104937209(pink1)

TBEN:

117487489

PGEO:

117440965(pink1)

GACU:

117549371(pink1)

EMAC:

134862163(pink1)

ELY:	117258905(pink1)

EFO:	125891898(pink1)

PLEP:

121947126(pink1)

SLUC:

116043719(pink1)

ECRA:

117947115(pink1)

ESP:	116691963(pink1)

PFLV:

114558462(pink1)

GAT:	120828727(pink1)

PPUG:

119223771(pink1)

AFB:	129099913(pink1)

CLUM:

117733110(pink1)

PSWI:

130199833(pink1)

CANA:

137801034(pink1)

CVE:	137889498(pink1)

MSAM:

119905159(pink1)

SCHU:

122883692(pink1)

CUD:	121517705(pink1)

SPUL:

138589678(pink1)

LMIX:

132989996(pink1)

ALAT:

119022791(pink1)

ASTR:

137610909(pink1)

MZE:	101472469(pink1)

ONL:	100701609(pink1)

OAU:	116321976(pink1)

OLA:	101159103(pink1)

OML:	112159615(pink1)

CSAI:

133456673(pink1)

XMA:	102234169(pink1)

XCO:	114140467(pink1)

XHE:	116716975(pink1)

PRET:

103467817(pink1)

PFOR:

103156800(pink1)

PLAI:

106950827(pink1)

PMEI:

106921821(pink1)

GAF:	122833929(pink1)

PPRL:

129376993(pink1)

CVG:	107095066(pink1)

CTUL:

119799501(pink1)

GMU:	124877221(pink1)

NFU:	107390418(pink1)

KMR:	108237629(pink1)

ALIM:

106529073(pink1)

NWH:	119416715(pink1)

AOCE:

111562744(pink1)

EJA:	138193382(pink1)

BFRE:

138628095(pink1)

MCEP:

125022343(pink1)

CSEM:

103385276(pink1)

POV:	109641931(pink1) 109646196

SSEN:

122777821(pink1)

SSOE:

131469202(pink1)

HHIP:

117764342(pink1)

HSP:	118110671(pink1)

PPLT:

128442244(pink1)

SMAU:

118316776(pink1)

LCF:	108888646 108888944

SDU:	111235113(pink1)

SLAL:

111669380(pink1)

XGL:	120804334(pink1)

BPEC:

110159396(pink1)

ENY:	140362968(pink1)

MALB:

109951219(pink1)

BSPL:

114859272(pink1)

SJO:	128357821(pink1)

SSCO:

133988344(pink1)

GMH:	115546770(pink1)

SASA:

106572550(pink1)

STRU:

115165629

OTW:	112216273(pink1)

OMY:	110532582(pink1)

OGO:

ONE:

OKI:

OKE:

OMM:

OCLA:

SALP:

111976414(pink1)

SNH:	120059171(pink1)

CCLU:

121537423(pink1)

ELS:	105028694(pink1)

OEP:	134018719(pink1)

SFM:	108939374(pink1)

PKI:	111855717(pink1)

AANG:

118208536(pink1)

AROT:

135234560(pink1)

CCOG:

133139058(pink1)

LOC:	102692173(pink1)

PSPA:

121329075 121329247

ARUT:

117426073

PSEX:

120530942(pink1)

LCM:	102358303(PINK1)

CMK:	103187676(pink1)

RTP:	109927832(pink1)

CPLA:

122540285(pink1)

HOC:	132833739(pink1)

LERI:

129711510(pink1)

BFO:

BBEL:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DER:

DSI:	Dsimw501_GD24757(Dsim_GD24757)

DYA:	Dyak_GE16766

DSR:

DPO:

DPE:

DMN:

DWI:

DMO:	Dmoj_GI21816(Dmoj_Tes31)

DAZ:

DNV:

DHE:

AGA:

ACOZ:

AARA:

AMAP:

AMRS:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ009758

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139113604(Pink1)

HST:

DQU:

CFO:

FEX:

PMEC:

138943239(Pink1)

LHU:	105677360(Pink1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

LHT:

LBD:

MDL:

CGLO:

TCA:

TMOL:

138131271(Pink1)

DPA:

109543781

ESIM:

136415093(Pink1)

EFOR:

136342659(Pink1)

AGRG:

ATD:

HAXR:

LDC:

DVV:

NVL:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM577390

ZNE:

BROR:

HAMR:

FCD:

AFRA:

EAF:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136975965(Pink1)

PTEP:

ABRU:

LPOL:

PMEO:

CEL:	CELE_EEED8.9(pink-1)

CBR:	CBG_02385(Cbr-pink-1)

CRQ:	GCK72_006015

NAI:	NECAME_12182

BMY:	BM_BM3116(Bma-pink-1)

LOA:	LOAG_04986

LGI:	LOTGIDRAFT_207719

PCAN:

LSAX:

HRF:

HASI:

HCRA:

CRG:

OED:

MYI:

PMAX:

AIRR:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_056390

SHX:	MS3_00002629(PINK1)

OVI:	T265_02910 T265_02911

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HSY:

RES:

TAD:	TRIADDRAFT_53330

AQU:

100631577

» show all

Reference

PMID:19966284

Authors

Vives-Bauza C, Zhou C, Huang Y, Cui M, de Vries RL, Kim J, May J, Tocilescu MA, Liu W, Ko HS, Magrane J, Moore DJ, Dawson VL, Grailhe R, Dawson TM, Li C, Tieu K, Przedborski S

Title

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.

Journal

Proc Natl Acad Sci U S A 107:378-83 (2010)
DOI:10.1073/pnas.0911187107

Sequence

[hsa:65018]

LinkDB

DBGET integrated database retrieval system