KEGG   Homo sapiens (human): 675
Entry
675               CDS       T01001                                 
Symbol
BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11
Name
(RefSeq) BRCA2 DNA repair associated
  KO
K08775  breast cancer 2 susceptibility protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
hsa05200  Pathways in cancer
hsa05212  Pancreatic cancer
hsa05224  Breast cancer
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01452  Homologous recombination
N01466  Homologous recombination in ICLR
Disease
H00019  Pancreatic cancer
H00027  Ovarian cancer
H00031  Breast cancer
H00042  Glioma
H00238  Fanconi anemia
H01554  Fallopian tube cancer
H02301  Nephroblastoma
H02531  Familial breast-ovarian cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    675 (BRCA2)
   03460 Fanconi anemia pathway
    675 (BRCA2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    675 (BRCA2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    675 (BRCA2)
   05224 Breast cancer
    675 (BRCA2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    675 (BRCA2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    675 (BRCA2)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    675 (BRCA2)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit type E3
   BRCC complex
    675 (BRCA2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     675 (BRCA2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA complex
     675 (BRCA2)
   FA (Fanconi anemia) pathway
    Downstream FA components
     675 (BRCA2)
SSDB
Motif
Pfam: BRCA-2_helical BRCA2 BRCA-2_OB3 BRCA-2_OB1 BRCA2_TR2 BRCA2DBD_OB2 Tower Terminase_3C
Other DBs
NCBI-GeneID: 675
NCBI-ProteinID: NP_000050
OMIM: 600185
HGNC: 1101
Ensembl: ENSG00000139618
UniProt: P51587 A0A7P0T9D7
Structure
LinkDB
Position
13:32315077..32400268
AA seq 3418 aa
MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNSEPAEESEHKNNNYEPN
LFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFKLDLGRNVPNSRHKSLRTV
KTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVVCGSLFHTPKFVKGRQTPKHI
SESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASETVFPHDTTANVKSYFSNHDESL
KKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKVNSCKDHIGKSMPNVLEDEVYETVV
DTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFHEANADECEKSKNQVKEKYSFVSEVEP
NDTDPLDSNVANQKPFESGSDKISKEVVPSLACEWSQLTLSGLNGAQMEKIPLLHISSCD
QNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEKPLNEETVVNKRDEEQHLESHTDC
ILAVKQAISGTSPVASSFQGIKKSIFRIRESPKETFNASFSGHMTDPNFKKETEASESGL
EIHTVCSQKEDSLCPNLIDNGSWPATTTQNSVALKNAGLISTLKKKTNKFIYAIHDETSY
KGKKIPKDQKSELINCSAQFEANAFEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLT
SSFGTILRKCSRNETCSNNTVISQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCEND
PKSKKVSDIKEEVLAAACHPVQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLS
NLVMISRGKESYKMSDKLKGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYM
RVASPSRKVQFNQNTNLRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNN
LALGNTKELHETDLTCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVK
QHIKMTLGQDLKSDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLS
EHNIKKSKMFFKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSD
CKNSHITPQMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKS
TFEVPENQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDC
NKSASGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISL
SSSKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENE
DNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNTQI
KEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNISVAK
ESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKESVPVGTG
NQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQGTSEITSFS
HQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETVVPPKLLSDNL
CRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSALAFYTSCSRKTS
VSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAENDKNHLSEKQDTYL
SNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKNTSFSKVISNVKDANAY
PQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPPAFRIASGKIVCVSHETIK
KVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDSEDILHNSLDNDECSTHSHKV
FADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDICKCSIGKLHKSVSSANTCGIFST
ASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLFKSNEHSDQLTREENTAIRTPEHLI
SQKGFSYNVVNSSAFSGFSTASGKQVSILESSLHKVKGVLEEFDLIRTEHSLHYSPTSRQ
NVSKILPRVDKRNPEHCVNSEMEKTCSKEFKLSNNLNVEGGSSENNHSIKVSPYLSQFQQ
DKQQLVLGTKVSLVENIHVLGKEQASPKNVKMEIGKTETFSDVPVKTNIEVCSTYSKDSE
NYFETEAVEIAKAFMEDDELTDSKLPSHATHSLFTCPENEEMVLSNSRIGKRRGEPLILV
GEPSIKRNLLNEFDRIIENQEKSLKASKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKE
RQEIQNPNFTAPGQEFLSKSHLYEHLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTG
RPTKVFVPPFKTKSHFHRVEQCVRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKN
NSNQAVAVTFTKCEEEPLDLITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPR
ISLKAAVGGQVPSACSHKQLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQ
LADGGWLIPSNDGKAGKEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPK
EFANRCLSPERVLLQLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANI
SETSSNKTSSADTQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVG
SPDACTPLEAPESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDV
IIQRAYPIQWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENT
TKPYLPSRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKK
QAQIQLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLL
TEGKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKF
LDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHMLI
AASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEAENKL
MHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCMAKRKSV
STPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSPAAQKAFQP
PRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEK
QFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
NT seq 10257 nt   +upstreamnt  +downstreamnt
atgcctattggatccaaagagaggccaacattttttgaaatttttaagacacgctgcaac
aaagcagatttaggaccaataagtcttaattggtttgaagaactttcttcagaagctcca
ccctataattctgaacctgcagaagaatctgaacataaaaacaacaattacgaaccaaac
ctatttaaaactccacaaaggaaaccatcttataatcagctggcttcaactccaataata
ttcaaagagcaagggctgactctgccgctgtaccaatctcctgtaaaagaattagataaa
ttcaaattagacttaggaaggaatgttcccaatagtagacataaaagtcttcgcacagtg
aaaactaaaatggatcaagcagatgatgtttcctgtccacttctaaattcttgtcttagt
gaaagtcctgttgttctacaatgtacacatgtaacaccacaaagagataagtcagtggta
tgtgggagtttgtttcatacaccaaagtttgtgaagggtcgtcagacaccaaaacatatt
tctgaaagtctaggagctgaggtggatcctgatatgtcttggtcaagttctttagctaca
ccacccacccttagttctactgtgctcatagtcagaaatgaagaagcatctgaaactgta
tttcctcatgatactactgctaatgtgaaaagctatttttccaatcatgatgaaagtctg
aagaaaaatgatagatttatcgcttctgtgacagacagtgaaaacacaaatcaaagagaa
gctgcaagtcatggatttggaaaaacatcagggaattcatttaaagtaaatagctgcaaa
gaccacattggaaagtcaatgccaaatgtcctagaagatgaagtatatgaaacagttgta
gatacctctgaagaagatagtttttcattatgtttttctaaatgtagaacaaaaaatcta
caaaaagtaagaactagcaagactaggaaaaaaattttccatgaagcaaacgctgatgaa
tgtgaaaaatctaaaaaccaagtgaaagaaaaatactcatttgtatctgaagtggaacca
aatgatactgatccattagattcaaatgtagcaaatcagaagccctttgagagtggaagt
gacaaaatctccaaggaagttgtaccgtctttggcctgtgaatggtctcaactaaccctt
tcaggtctaaatggagcccagatggagaaaatacccctattgcatatttcttcatgtgac
caaaatatttcagaaaaagacctattagacacagagaacaaaagaaagaaagattttctt
acttcagagaattctttgccacgtatttctagcctaccaaaatcagagaagccattaaat
gaggaaacagtggtaaataagagagatgaagagcagcatcttgaatctcatacagactgc
attcttgcagtaaagcaggcaatatctggaacttctccagtggcttcttcatttcagggt
atcaaaaagtctatattcagaataagagaatcacctaaagagactttcaatgcaagtttt
tcaggtcatatgactgatccaaactttaaaaaagaaactgaagcctctgaaagtggactg
gaaatacatactgtttgctcacagaaggaggactccttatgtccaaatttaattgataat
ggaagctggccagccaccaccacacagaattctgtagctttgaagaatgcaggtttaata
tccactttgaaaaagaaaacaaataagtttatttatgctatacatgatgaaacatcttat
aaaggaaaaaaaataccgaaagaccaaaaatcagaactaattaactgttcagcccagttt
gaagcaaatgcttttgaagcaccacttacatttgcaaatgctgattcaggtttattgcat
tcttctgtgaaaagaagctgttcacagaatgattctgaagaaccaactttgtccttaact
agctcttttgggacaattctgaggaaatgttctagaaatgaaacatgttctaataataca
gtaatctctcaggatcttgattataaagaagcaaaatgtaataaggaaaaactacagtta
tttattaccccagaagctgattctctgtcatgcctgcaggaaggacagtgtgaaaatgat
ccaaaaagcaaaaaagtttcagatataaaagaagaggtcttggctgcagcatgtcaccca
gtacaacattcaaaagtggaatacagtgatactgactttcaatcccagaaaagtctttta
tatgatcatgaaaatgccagcactcttattttaactcctacttccaaggatgttctgtca
aacctagtcatgatttctagaggcaaagaatcatacaaaatgtcagacaagctcaaaggt
aacaattatgaatctgatgttgaattaaccaaaaatattcccatggaaaagaatcaagat
gtatgtgctttaaatgaaaattataaaaacgttgagctgttgccacctgaaaaatacatg
agagtagcatcaccttcaagaaaggtacaattcaaccaaaacacaaatctaagagtaatc
caaaaaaatcaagaagaaactacttcaatttcaaaaataactgtcaatccagactctgaa
gaacttttctcagacaatgagaataattttgtcttccaagtagctaatgaaaggaataat
cttgctttaggaaatactaaggaacttcatgaaacagacttgacttgtgtaaacgaaccc
attttcaagaactctaccatggttttatatggagacacaggtgataaacaagcaacccaa
gtgtcaattaaaaaagatttggtttatgttcttgcagaggagaacaaaaatagtgtaaag
cagcatataaaaatgactctaggtcaagatttaaaatcggacatctccttgaatatagat
aaaataccagaaaaaaataatgattacatgaacaaatgggcaggactcttaggtccaatt
tcaaatcacagttttggaggtagcttcagaacagcttcaaataaggaaatcaagctctct
gaacataacattaagaagagcaaaatgttcttcaaagatattgaagaacaatatcctact
agtttagcttgtgttgaaattgtaaataccttggcattagataatcaaaagaaactgagc
aagcctcagtcaattaatactgtatctgcacatttacagagtagtgtagttgtttctgat
tgtaaaaatagtcatataacccctcagatgttattttccaagcaggattttaattcaaac
cataatttaacacctagccaaaaggcagaaattacagaactttctactatattagaagaa
tcaggaagtcagtttgaatttactcagtttagaaaaccaagctacatattgcagaagagt
acatttgaagtgcctgaaaaccagatgactatcttaaagaccacttctgaggaatgcaga
gatgctgatcttcatgtcataatgaatgccccatcgattggtcaggtagacagcagcaag
caatttgaaggtacagttgaaattaaacggaagtttgctggcctgttgaaaaatgactgt
aacaaaagtgcttctggttatttaacagatgaaaatgaagtggggtttaggggcttttat
tctgctcatggcacaaaactgaatgtttctactgaagctctgcaaaaagctgtgaaactg
tttagtgatattgagaatattagtgaggaaacttctgcagaggtacatccaataagttta
tcttcaagtaaatgtcatgattctgttgtttcaatgtttaagatagaaaatcataatgat
aaaactgtaagtgaaaaaaataataaatgccaactgatattacaaaataatattgaaatg
actactggcacttttgttgaagaaattactgaaaattacaagagaaatactgaaaatgaa
gataacaaatatactgctgccagtagaaattctcataacttagaatttgatggcagtgat
tcaagtaaaaatgatactgtttgtattcataaagatgaaacggacttgctatttactgat
cagcacaacatatgtcttaaattatctggccagtttatgaaggagggaaacactcagatt
aaagaagatttgtcagatttaacttttttggaagttgcgaaagctcaagaagcatgtcat
ggtaatacttcaaataaagaacagttaactgctactaaaacggagcaaaatataaaagat
tttgagacttctgatacattttttcagactgcaagtgggaaaaatattagtgtcgccaaa
gagtcatttaataaaattgtaaatttctttgatcagaaaccagaagaattgcataacttt
tccttaaattctgaattacattctgacataagaaagaacaaaatggacattctaagttat
gaggaaacagacatagttaaacacaaaatactgaaagaaagtgtcccagttggtactgga
aatcaactagtgaccttccagggacaacccgaacgtgatgaaaagatcaaagaacctact
ctattgggttttcatacagctagcgggaaaaaagttaaaattgcaaaggaatctttggac
aaagtgaaaaacctttttgatgaaaaagagcaaggtactagtgaaatcaccagttttagc
catcaatgggcaaagaccctaaagtacagagaggcctgtaaagaccttgaattagcatgt
gagaccattgagatcacagctgccccaaagtgtaaagaaatgcagaattctctcaataat
gataaaaaccttgtttctattgagactgtggtgccacctaagctcttaagtgataattta
tgtagacaaactgaaaatctcaaaacatcaaaaagtatctttttgaaagttaaagtacat
gaaaatgtagaaaaagaaacagcaaaaagtcctgcaacttgttacacaaatcagtcccct
tattcagtcattgaaaattcagccttagctttttacacaagttgtagtagaaaaacttct
gtgagtcagacttcattacttgaagcaaaaaaatggcttagagaaggaatatttgatggt
caaccagaaagaataaatactgcagattatgtaggaaattatttgtatgaaaataattca
aacagtactatagctgaaaatgacaaaaatcatctctccgaaaaacaagatacttattta
agtaacagtagcatgtctaacagctattcctaccattctgatgaggtatataatgattca
ggatatctctcaaaaaataaacttgattctggtattgagccagtattgaagaatgttgaa
gatcaaaaaaacactagtttttccaaagtaatatccaatgtaaaagatgcaaatgcatac
ccacaaactgtaaatgaagatatttgcgttgaggaacttgtgactagctcttcaccctgc
aaaaataaaaatgcagccattaaattgtccatatctaatagtaataattttgaggtaggg
ccacctgcatttaggatagccagtggtaaaatcgtttgtgtttcacatgaaacaattaaa
aaagtgaaagacatatttacagacagtttcagtaaagtaattaaggaaaacaacgagaat
aaatcaaaaatttgccaaacgaaaattatggcaggttgttacgaggcattggatgattca
gaggatattcttcataactctctagataatgatgaatgtagcacgcattcacataaggtt
tttgctgacattcagagtgaagaaattttacaacataaccaaaatatgtctggattggag
aaagtttctaaaatatcaccttgtgatgttagtttggaaacttcagatatatgtaaatgt
agtatagggaagcttcataagtcagtctcatctgcaaatacttgtgggatttttagcaca
gcaagtggaaaatctgtccaggtatcagatgcttcattacaaaacgcaagacaagtgttt
tctgaaatagaagatagtaccaagcaagtcttttccaaagtattgtttaaaagtaacgaa
cattcagaccagctcacaagagaagaaaatactgctatacgtactccagaacatttaata
tcccaaaaaggcttttcatataatgtggtaaattcatctgctttctctggatttagtaca
gcaagtggaaagcaagtttccattttagaaagttccttacacaaagttaagggagtgtta
gaggaatttgatttaatcagaactgagcatagtcttcactattcacctacgtctagacaa
aatgtatcaaaaatacttcctcgtgttgataagagaaacccagagcactgtgtaaactca
gaaatggaaaaaacctgcagtaaagaatttaaattatcaaataacttaaatgttgaaggt
ggttcttcagaaaataatcactctattaaagtttctccatatctctctcaatttcaacaa
gacaaacaacagttggtattaggaaccaaagtgtcacttgttgagaacattcatgttttg
ggaaaagaacaggcttcacctaaaaacgtaaaaatggaaattggtaaaactgaaactttt
tctgatgttcctgtgaaaacaaatatagaagtttgttctacttactccaaagattcagaa
aactactttgaaacagaagcagtagaaattgctaaagcttttatggaagatgatgaactg
acagattctaaactgccaagtcatgccacacattctctttttacatgtcccgaaaatgag
gaaatggttttgtcaaattcaagaattggaaaaagaagaggagagccccttatcttagtg
ggagaaccctcaatcaaaagaaacttattaaatgaatttgacaggataatagaaaatcaa
gaaaaatccttaaaggcttcaaaaagcactccagatggcacaataaaagatcgaagattg
tttatgcatcatgtttctttagagccgattacctgtgtaccctttcgcacaactaaggaa
cgtcaagagatacagaatccaaattttaccgcacctggtcaagaatttctgtctaaatct
catttgtatgaacatctgactttggaaaaatcttcaagcaatttagcagtttcaggacat
ccattttatcaagtttctgctacaagaaatgaaaaaatgagacacttgattactacaggc
agaccaaccaaagtctttgttccaccttttaaaactaaatcacattttcacagagttgaa
cagtgtgttaggaatattaacttggaggaaaacagacaaaagcaaaacattgatggacat
ggctctgatgatagtaaaaataagattaatgacaatgagattcatcagtttaacaaaaac
aactccaatcaagcagtagctgtaactttcacaaagtgtgaagaagaacctttagattta
attacaagtcttcagaatgccagagatatacaggatatgcgaattaagaagaaacaaagg
caacgcgtctttccacagccaggcagtctgtatcttgcaaaaacatccactctgcctcga
atctctctgaaagcagcagtaggaggccaagttccctctgcgtgttctcataaacagctg
tatacgtatggcgtttctaaacattgcataaaaattaacagcaaaaatgcagagtctttt
cagtttcacactgaagattattttggtaaggaaagtttatggactggaaaaggaatacag
ttggctgatggtggatggctcataccctccaatgatggaaaggctggaaaagaagaattt
tatagggctctgtgtgacactccaggtgtggatccaaagcttatttctagaatttgggtt
tataatcactatagatggatcatatggaaactggcagctatggaatgtgcctttcctaag
gaatttgctaatagatgcctaagcccagaaagggtgcttcttcaactaaaatacagatat
gatacggaaattgatagaagcagaagatcggctataaaaaagataatggaaagggatgac
acagctgcaaaaacacttgttctctgtgtttctgacataatttcattgagcgcaaatata
tctgaaacttctagcaataaaactagtagtgcagatacccaaaaagtggccattattgaa
cttacagatgggtggtatgctgttaaggcccagttagatcctcccctcttagctgtctta
aagaatggcagactgacagttggtcagaagattattcttcatggagcagaactggtgggc
tctcctgatgcctgtacacctcttgaagccccagaatctcttatgttaaagatttctgct
aacagtactcggcctgctcgctggtataccaaacttggattctttcctgaccctagacct
tttcctctgcccttatcatcgcttttcagtgatggaggaaatgttggttgtgttgatgta
attattcaaagagcataccctatacagtggatggagaagacatcatctggattatacata
tttcgcaatgaaagagaggaagaaaaggaagcagcaaaatatgtggaggcccaacaaaag
agactagaagccttattcactaaaattcaggaggaatttgaagaacatgaagaaaacaca
acaaaaccatatttaccatcacgtgcactaacaagacagcaagttcgtgctttgcaagat
ggtgcagagctttatgaagcagtgaagaatgcagcagacccagcttaccttgagggttat
ttcagtgaagagcagttaagagccttgaataatcacaggcaaatgttgaatgataagaaa
caagctcagatccagttggaaattaggaaggccatggaatctgctgaacaaaaggaacaa
ggtttatcaagggatgtcacaaccgtgtggaagttgcgtattgtaagctattcaaaaaaa
gaaaaagattcagttatactgagtatttggcgtccatcatcagatttatattctctgtta
acagaaggaaagagatacagaatttatcatcttgcaacttcaaaatctaaaagtaaatct
gaaagagctaacatacagttagcagcgacaaaaaaaactcagtatcaacaactaccggtt
tcagatgaaattttatttcagatttaccagccacgggagccccttcacttcagcaaattt
ttagatccagactttcagccatcttgttctgaggtggacctaataggatttgtcgtttct
gttgtgaaaaaaacaggacttgcccctttcgtctatttgtcagacgaatgttacaattta
ctggcaataaagttttggatagaccttaatgaggacattattaagcctcatatgttaatt
gctgcaagcaacctccagtggcgaccagaatccaaatcaggccttcttactttatttgct
ggagatttttctgtgttttctgctagtccaaaagagggccactttcaagagacattcaac
aaaatgaaaaatactgttgagaatattgacatactttgcaatgaagcagaaaacaagctt
atgcatatactgcatgcaaatgatcccaagtggtccaccccaactaaagactgtacttca
gggccgtacactgctcaaatcattcctggtacaggaaacaagcttctgatgtcttctcct
aattgtgagatatattatcaaagtcctttatcactttgtatggccaaaaggaagtctgtt
tccacacctgtctcagcccagatgacttcaaagtcttgtaaaggggagaaagagattgat
gaccaaaagaactgcaaaaagagaagagccttggatttcttgagtagactgcctttacct
ccacctgttagtcccatttgtacatttgtttctccggctgcacagaaggcatttcagcca
ccaaggagttgtggcaccaaatacgaaacacccataaagaaaaaagaactgaattctcct
cagatgactccatttaaaaaattcaatgaaatttctcttttggaaagtaattcaatagct
gacgaagaacttgcattgataaatacccaagctcttttgtctggttcaacaggagaaaaa
caatttatatctgtcagtgaatccactaggactgctcccaccagttcagaagattatctc
agactgaaacgacgttgtactacatctctgatcaaagaacaggagagttcccaggccagt
acggaagaatgtgagaaaaataagcaggacacaattacaactaaaaaatatatctaa

KEGG   Homo sapiens (human): 79728
Entry
79728             CDS       T01001                                 
Symbol
PALB2, BROVCA5, FANCN, PNCA3
Name
(RefSeq) partner and localizer of BRCA2
  KO
K10897  partner and localizer of BRCA2
Organism
hsa  Homo sapiens (human)
Pathway
hsa03440  Homologous recombination
hsa03460  Fanconi anemia pathway
Network
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01452  Homologous recombination
N01466  Homologous recombination in ICLR
Disease
H00019  Pancreatic cancer
H00031  Breast cancer
H00238  Fanconi anemia
H02531  Familial breast-ovarian cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    79728 (PALB2)
   03460 Fanconi anemia pathway
    79728 (PALB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:hsa03400]
    79728 (PALB2)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA complex
     79728 (PALB2)
   FA (Fanconi anemia) pathway
    Downstream FA components
     79728 (PALB2)
SSDB
Motif
Pfam: PALB2_WD40 Beta-prop_WDR19_1st
Other DBs
NCBI-GeneID: 79728
NCBI-ProteinID: NP_078951
OMIM: 610355
HGNC: 26144
Ensembl: ENSG00000083093
UniProt: Q86YC2
Structure
LinkDB
Position
16:complement(23603165..23641310)
AA seq 1186 aa
MDEPPGKPLSCEEKEKLKEKLAFLKREYSKTLARLQRAQRAEKIKHSIKKTVEEQDCLSQ
QDLSPQLKHSEPKNKICVYDKLHIKTHLDEETGEKTSITLDVGPESFNPGDGPGGLPIQR
TDDTQEHFPHRVSDPSGEQKQKLPSRRKKQQKRTFISQERDCVFGTDSLRLSGKRLKEQE
EISSKNPARSPVTEIRTHLLSLKSELPDSPEPVTEINEDSVLIPPTAQPEKGVDTFLRRP
NFTRATTVPLQTLSDSGSSQHLEHIPPKGSSELTTHDLKNIRFTSPVSLEAQGKKMTVST
DNLLVNKAISKSGQLPTSSNLEANISCSLNELTYNNLPANENQNLKEQNQTEKSLKSPSD
TLDGRNENLQESEILSQPKSLSLEATSPLSAEKHSCTVPEGLLFPAEYYVRTTRSMSNCQ
RKVAVEAVIQSHLDVKKKGFKNKNKDASKNLNLSNEETDQSEIRMSGTCTGQPSSRTSQK
LLSLTKVSSPAGPTEDNDLSRKAVAQAPGRRYTGKRKSACTPASDHCEPLLPTSSLSIVN
RSKEEVTSHKYQHEKLFIQVKGKKSRHQKEDSLSWSNSAYLSLDDDAFTAPFHRDGMLSL
KQLLSFLSITDFQLPDEDFGPLKLEKVKSCSEKPVEPFESKMFGERHLKEGSCIFPEELS
PKRMDTEMEDLEEDLIVLPGKSHPKRPNSQSQHTKTGLSSSILLYTPLNTVAPDDNDRPT
TDMCSPAFPILGTTPAFGPQGSYEKASTEVAGRTCCTPQLAHLKDSVCLASDTKQFDSSG
SPAKPHTTLQVSGRQGQPTCDCDSVPPGTPPPIESFTFKENQLCRNTCQELHKHSVEQTE
TAELPASDSINPGNLQLVSELKNPSGSCSVDVSAMFWERAGCKEPCIITACEDVVSLWKA
LDAWQWEKLYTWHFAEVPVLQIVPVPDVYNLVCVALGNLEIREIRALFCSSDDESEKQVL
LKSGNIKAVLGLTKRRLVSSSGTLSDQQVEVMTFAEDGGGKENQFLMPPEETILTFAEVQ
GMQEALLGTTIMNNIVIWNLKTGQLLKKMHIDDSYQASVCHKAYSEMGLLFIVLSHPCAK
ESESLRSPVFQLIVINPKTTLSVGVMLYCLPPGQAGRFLEGDVKDHCAAAILTSGTIAIW
DLLLGQCTALLPPVSDQHWSFVKWSGTDSHLLAGQKDGNIFVYHYS
NT seq 3561 nt   +upstreamnt  +downstreamnt
atggacgagcctcccgggaagcccctcagctgtgaggagaaggaaaagttaaaggagaaa
ttagcattcttgaaaagggaatacagcaagacactagcccgccttcagcgtgcccaaaga
gctgaaaagattaagcattctattaagaaaacagtagaagaacaagattgtttgtctcag
caggatctctcaccgcagctaaaacactcagaacctaaaaataaaatatgtgtttatgac
aagttacacatcaaaacccatcttgatgaagaaactggagaaaagacatctatcacactt
gatgttgggcctgagtcctttaaccctggagatggcccaggaggattacctatacaaaga
acagatgacacccaagaacattttccccacagggtcagtgaccctagtggtgagcaaaag
cagaagctgccaagcagaagaaagaagcagcagaagaggacatttatttcacaggagaga
gactgtgtctttggcactgattcactcagattgtctgggaaaagactaaaggaacaggaa
gaaatcagtagcaaaaatcctgctagatcaccagtaactgaaataagaactcacctttta
agtcttaaatctgaacttccagattctccagaaccagttacagaaattaatgaagacagt
gtattaattccaccaactgcccaaccagaaaaaggtgttgatacattcctaagaagacct
aatttcaccagggcgactacagttcctttacagactctatcagatagcggtagtagtcag
caccttgaacacattcctcctaaaggtagcagtgaacttactactcacgacctaaaaaac
attagatttacttcacctgtaagtttggaggcacaaggcaaaaaaatgactgtctctaca
gataacctccttgtaaataaagctataagtaaaagtggccaactgcccacaagttctaat
ttagaggcaaatatttcatgttctctaaatgaactcacctacaataacttaccagcaaat
gaaaaccaaaacttaaaagaacaaaatcaaacagagaaatctttaaaatctcccagtgac
actcttgatggcaggaatgaaaatcttcaggaaagtgagattctaagtcaacctaagagt
cttagcctggaagcaacctctcctctttctgcagaaaaacattcttgcacagtgcctgaa
ggccttctgtttcctgcagaatattatgttagaacaacacgaagcatgtccaattgccag
aggaaagtagccgtggaggctgtcattcagagtcatttggatgtcaagaaaaaagggttt
aaaaataaaaataaggatgcaagtaaaaatttaaacctttccaatgaggaaactgaccaa
agtgaaattaggatgtctggcacatgcacaggacaaccaagttcaagaacctctcagaaa
cttctctcattaactaaagtcagctctcccgctgggcccactgaagataatgacttgtct
aggaaggcagttgcccaagcacctggtagaagatacacaggaaaaagaaaatcagcctgc
accccagcatcagatcattgtgaaccacttttgccaacttctagcctgtcgattgttaac
aggtccaaggaagaagtcacctcacacaaatatcagcacgaaaaattatttattcaagtg
aaagggaagaaaagtcgtcatcaaaaagaggattccctttcttggagtaatagtgcttat
ttatccttggatgatgatgctttcacggctccatttcatagggatggaatgctgagttta
aagcaactactgtcttttctcagtatcacagactttcagttacctgatgaagactttgga
cctcttaagcttgaaaaagtgaagtcctgctcagaaaaaccagtggagccctttgagtca
aaaatgtttggagagagacatcttaaagagggaagctgtatttttccagaggaactgagt
cctaaacgcatggatacagaaatggaggacttagaagaggaccttattgttctaccagga
aaatcacatcccaaaaggccaaactcgcaaagccagcatacaaagacgggcctttcttca
tccatattactttatactcctttaaatacggttgcgcctgatgataatgacaggcctacc
acagacatgtgttcacctgctttccccatcttaggtactactccagcctttggccctcaa
ggctcctatgaaaaagcatctacagaagttgctggacgaacttgctgcacaccccaactt
gctcatttgaaagactcagtctgtcttgccagtgatactaaacaattcgacagttcaggc
agcccagcaaaaccacataccaccctgcaagtgtcaggcaggcaaggacaacctacctgt
gactgtgactctgtcccgccaggaacacctccacccattgagtcattcacttttaaagaa
aatcagctctgtagaaacacatgccaggagctgcataaacattccgtcgaacagactgaa
acagcagagcttcctgcttctgatagcataaacccaggcaacctacaattggtttcagag
ttaaagaatccttcaggttcctgttccgtagatgtgagtgccatgttttgggaaagagcc
ggttgtaaagagccatgtatcataactgcttgcgaagatgtagtttctctttggaaagct
ctggatgcttggcagtgggaaaaactttatacctggcacttcgcagaggttccagtatta
cagatagttccagtgcctgatgtgtataatctcgtgtgtgtagctttgggaaatttggaa
atcagagagatcagggcattgttttgttcctctgatgatgaaagtgaaaagcaagtacta
ctgaagtctggaaatataaaagctgtgcttggcctgacaaagaggaggctagttagtagc
agtgggaccctttctgatcaacaagtagaagtcatgacgtttgcagaagatggaggaggc
aaagaaaaccaatttttgatgccccctgaggagactatactaacttttgctgaggtccaa
gggatgcaagaagctctgcttggtactactattatgaacaacattgttatttggaattta
aaaactggtcaactcctgaaaaagatgcacattgatgattcttaccaagcttcagtctgt
cacaaagcctattctgaaatggggcttctctttattgtcctgagtcatccctgtgccaaa
gagagtgagtcgttgcgaagccctgtgtttcagctcattgtgattaaccctaagacgact
ctcagcgtgggtgtgatgctgtactgtcttcctccagggcaggctggcaggttcctggaa
ggtgacgtgaaagatcactgtgcagcagcaatcttgacttctggaacaattgccatttgg
gacttacttctcggtcagtgtactgccctcctcccacctgtctctgaccaacattggtct
tttgtgaaatggtcgggtacagactctcatttgctggctggacaaaaagatggaaatata
tttgtataccactattcataa

KEGG   Homo sapiens (human): 7979
Entry
7979              CDS       T01001                                 
Symbol
SEM1, C7orf76, DSS1, ECD, PSMD15, SHFD1, SHFM1, SHSF1, Shfdg1
Name
(RefSeq) SEM1 26S proteasome subunit
  KO
K10881  26 proteasome complex subunit DSS1
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa03440  Homologous recombination
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
nt06506  Double-strand break repair
nt06508  Interstrand crosslink repair
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
N01452  Homologous recombination
N01466  Homologous recombination in ICLR
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    7979 (SEM1)
  09124 Replication and repair
   03440 Homologous recombination
    7979 (SEM1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    7979 (SEM1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    7979 (SEM1)
   05012 Parkinson disease
    7979 (SEM1)
   05014 Amyotrophic lateral sclerosis
    7979 (SEM1)
   05016 Huntington disease
    7979 (SEM1)
   05017 Spinocerebellar ataxia
    7979 (SEM1)
   05020 Prion disease
    7979 (SEM1)
   05022 Pathways of neurodegeneration - multiple diseases
    7979 (SEM1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    7979 (SEM1)
   04131 Membrane trafficking [BR:hsa04131]
    7979 (SEM1)
   03051 Proteasome [BR:hsa03051]
    7979 (SEM1)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    7979 (SEM1)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   Transport factors
    TREX-2 complex
     7979 (SEM1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Tethering complex
   Exocyst complex assembly proteins
    7979 (SEM1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     7979 (SEM1)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     7979 (SEM1)
SSDB
Motif
Pfam: DSS1_SEM1
Other DBs
NCBI-GeneID: 7979
NCBI-ProteinID: NP_006295
OMIM: 601285
HGNC: 10845
Ensembl: ENSG00000127922
UniProt: P60896 Q6IBB7
Structure
LinkDB
Position
7:complement(96481626..96709846)
AA seq 70 aa
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAEL
EKHGYKMETS
NT seq 213 nt   +upstreamnt  +downstreamnt
atgtcagagaaaaagcagccggtagacttaggtctgttagaggaagacgacgagtttgaa
gagttccctgccgaagactgggctggcttagatgaagatgaagatgcacatgtctgggag
gataattgggatgatgacaatgtagaggatgacttctctaatcagttacgagctgaacta
gagaaacatggttataagatggagacttcatag

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