KEGG   DRUG: BelinostatHelp
Entry
D08870                      Drug                                   

Name
Belinostat (USAN/INN);
Beleodaq (TN)
Product
Formula
C15H14N2O4S
Exact mass
318.0674
Mol weight
318.3477
Structure
Mol fileKCF fileDB search
Class
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
 DG01642  CYP2C9 substrate
 DG02913  CYP3A4 substrate
 DG02924  UGT substrate
Remark
ATC code: L01XX49
Product: D08870<US>
Efficacy
Antineoplastic, Histone deacetylase inhibitor
  Disease
Peripheral T-cell lymphoma [DS:H01892]
Target
  Pathway
hsa04110  Cell cycle
hsa04330  Notch signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: UGT1A1 [HSA:54658]; CYP2A6 [HSA:1548], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX49 Belinostat
      D08870  Belinostat (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Belinostat
    D08870  Belinostat (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Histone deacetylase
    HDAC
     D08870  Belinostat (USAN/INN) <US>
Antineoplastics [br08340.html]
 D08870
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D08870
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08870
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D08870
BRITE hierarchy
Other DBs
CAS: 414864-00-9
PubChem: 96025553
ChEBI: 61076
ChEMBL: CHEMBL408513
PDB-CCD: 5OG[PDBj]
LigandBox: D08870
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C    19.2500  -16.8000
            2   C8x C    19.2500  -18.2000
            3   C8x C    20.4624  -18.9000
            4   C8x C    21.6749  -18.2000
            5   C8y C    21.6749  -16.8000
            6   C8x C    20.4624  -16.1000
            7   S4a S    18.0376  -16.1000
            8   N1b N    16.8251  -15.4000
            9   O3c O    18.7430  -14.8779
            10  O3c O    17.3434  -17.3027
            11  C8y C    15.5940  -16.1110
            12  C8x C    14.3888  -15.4153
            13  C8x C    13.1765  -16.1154
            14  C8x C    13.1765  -17.5154
            15  C8x C    14.3817  -18.2111
            16  C8x C    15.5941  -17.5110
            17  C2b C    22.9060  -16.0890
            18  C2b C    24.1112  -16.7847
            19  C5a C    25.2935  -16.1019
            20  N1b N    26.4875  -16.7912
            21  O5a O    25.2935  -14.7002
            22  O1b O    27.6754  -16.1052
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     7   9 2
            10    7  10 2
            11    8  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18    5  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23   20  22 1

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