KEGG   DRUG: BelinostatHelp
Entry
D08870                      Drug                                   

Name
Belinostat (USAN/INN);
Beleodaq (TN)
Product
Formula
C15H14N2O4S
Exact mass
318.0674
Mol weight
318.3477
Structure
Mol fileKCF fileDB search
Class
Enzyme substrate
 DG01638  CYP2A6 substrate
 DG01642  CYP2C9 substrate
Remark
ATC code: L01XX49
Product: D08870<US>
Efficacy
Antineoplastic, Histone deacetylase inhibitor
  Disease
Peripheral T-cell lymphoma [DS:H01892]
Target
  Pathway
hsa04110  Cell cycle
hsa04330  Notch signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: UGT1A1 [HSA:54658]; CYP2A6 [HSA:1548], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX49 Belinostat
      D08870  Belinostat (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Belinostat
    D08870  Belinostat (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Histone deacetylase
    HDAC
     D08870  Belinostat (USAN/INN) <US>
Antineoplastics [br08340.html]
 D08870
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D08870
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D08870
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D08870
BRITE hierarchy
Other DBs
CAS: 414864-00-9
PubChem: 96025553
ChEBI: 61076
ChEMBL: CHEMBL408513
PDB-CCD: 5OG[PDBj]
LigandBox: D08870
LinkDB All DBs
KCF data Show

ATOM        22
            1   C8y C    19.2500  -16.8000
            2   C8x C    19.2500  -18.2000
            3   C8x C    20.4624  -18.9000
            4   C8x C    21.6749  -18.2000
            5   C8y C    21.6749  -16.8000
            6   C8x C    20.4624  -16.1000
            7   S4a S    18.0376  -16.1000
            8   N1b N    16.8251  -15.4000
            9   O3c O    18.7430  -14.8779
            10  O3c O    17.3434  -17.3027
            11  C8y C    15.5940  -16.1110
            12  C8x C    14.3888  -15.4153
            13  C8x C    13.1765  -16.1154
            14  C8x C    13.1765  -17.5154
            15  C8x C    14.3817  -18.2111
            16  C8x C    15.5941  -17.5110
            17  C2b C    22.9060  -16.0890
            18  C2b C    24.1112  -16.7847
            19  C5a C    25.2935  -16.1019
            20  N1b N    26.4875  -16.7912
            21  O5a O    25.2935  -14.7002
            22  O1b O    27.6754  -16.1052
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     7   9 2
            10    7  10 2
            11    8  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   11  16 1
            18    5  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23   20  22 1

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