KEGG   Homo sapiens (human): 941
Entry
941               CDS       T01001                                 
Symbol
CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Name
(RefSeq) CD80 molecule
  KO
K05412  CD80 antigen
Organism
hsa  Homo sapiens (human)
Pathway
hsa03267  Virion - Adenovirus
hsa04514  Cell adhesion molecules
hsa04620  Toll-like receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa04940  Type I diabetes mellitus
hsa05320  Autoimmune thyroid disease
hsa05322  Systemic lupus erythematosus
hsa05323  Rheumatoid arthritis
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
hsa05416  Viral myocarditis
Network
nt06169  Measles virus (MV)
nt06537  TCR/BCR signaling
  Element
N00683  CD80/CD86-CD28-PI3K signaling pathway
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
Drug target
Abatacept: D03203<JP/US>
Belatacept: D03222<US>
Davoceticept: D12463
Galiximab: D04295
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03267 Virion - Adenovirus
    941 (CD80)
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    941 (CD80)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    941 (CD80)
   04672 Intestinal immune network for IgA production
    941 (CD80)
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    941 (CD80)
   05323 Rheumatoid arthritis
    941 (CD80)
   05320 Autoimmune thyroid disease
    941 (CD80)
   05330 Allograft rejection
    941 (CD80)
   05332 Graft-versus-host disease
    941 (CD80)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    941 (CD80)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    941 (CD80)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    941 (CD80)
CD molecules [BR:hsa04090]
 Proteins
  941 (CD80)
SSDB
Motif
Pfam: C2-set_2 V-set C2-set_3 Ig_3 ig I-set Ig_2
Other DBs
NCBI-GeneID: 941
NCBI-ProteinID: NP_005182
OMIM: 112203
HGNC: 1700
Ensembl: ENSG00000121594
UniProt: P33681 A0N0P2
Structure
LinkDB
Position
3:complement(119524293..119559614)
AA seq 288 aa
MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATLSCGHNVSVEELA
QTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLK
YEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGE
ELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFP
DNLLPSWAITLISVNGIFVICCLTYCFAPRCRERRRNERLRRESVRPV
NT seq 867 nt   +upstreamnt  +downstreamnt
atgggccacacacggaggcagggaacatcaccatccaagtgtccatacctcaatttcttt
cagctcttggtgctggctggtctttctcacttctgttcaggtgttatccacgtgaccaag
gaagtgaaagaagtggcaacgctgtcctgtggtcacaatgtttctgttgaagagctggca
caaactcgcatctactggcaaaaggagaagaaaatggtgctgactatgatgtctggggac
atgaatatatggcccgagtacaagaaccggaccatctttgatatcactaataacctctcc
attgtgatcctggctctgcgcccatctgacgagggcacatacgagtgtgttgttctgaag
tatgaaaaagacgctttcaagcgggaacacctggctgaagtgacgttatcagtcaaagct
gacttccctacacctagtatatctgactttgaaattccaacttctaatattagaaggata
atttgctcaacctctggaggttttccagagcctcacctctcctggttggaaaatggagaa
gaattaaatgccatcaacacaacagtttcccaagatcctgaaactgagctctatgctgtt
agcagcaaactggatttcaatatgacaaccaaccacagcttcatgtgtctcatcaagtat
ggacatttaagagtgaatcagaccttcaactggaatacaaccaagcaagagcattttcct
gataacctgctcccatcctgggccattaccttaatctcagtaaatggaatttttgtgata
tgctgcctgacctactgctttgccccaagatgcagagagagaaggaggaatgagagattg
agaagggaaagtgtacgccctgtataa

KEGG   Homo sapiens (human): 942
Entry
942               CDS       T01001                                 
Symbol
CD86, B7-2, B7.2, B70, CD28LG2, LAB72
Name
(RefSeq) CD86 molecule
  KO
K05413  CD86 antigen
Organism
hsa  Homo sapiens (human)
Pathway
hsa03267  Virion - Adenovirus
hsa04514  Cell adhesion molecules
hsa04620  Toll-like receptor signaling pathway
hsa04672  Intestinal immune network for IgA production
hsa04940  Type I diabetes mellitus
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05202  Transcriptional misregulation in cancer
hsa05320  Autoimmune thyroid disease
hsa05322  Systemic lupus erythematosus
hsa05323  Rheumatoid arthritis
hsa05330  Allograft rejection
hsa05332  Graft-versus-host disease
hsa05416  Viral myocarditis
Network
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06169  Measles virus (MV)
nt06229  MHC presentation (cancer)
nt06240  Transcription (cancer)
nt06537  TCR/BCR signaling
  Element
N00123  Amplified REL to transcription
N00185  KSHV MIR2 to cell surface molecule-endocytosis
N00683  CD80/CD86-CD28-PI3K signaling pathway
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
Drug target
Abatacept: D03203<JP/US>
Belatacept: D03222<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03267 Virion - Adenovirus
    942 (CD86)
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    942 (CD86)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    942 (CD86)
   04672 Intestinal immune network for IgA production
    942 (CD86)
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    942 (CD86)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    942 (CD86)
  09163 Immune disease
   05322 Systemic lupus erythematosus
    942 (CD86)
   05323 Rheumatoid arthritis
    942 (CD86)
   05320 Autoimmune thyroid disease
    942 (CD86)
   05330 Allograft rejection
    942 (CD86)
   05332 Graft-versus-host disease
    942 (CD86)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    942 (CD86)
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    942 (CD86)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    942 (CD86)
   04090 CD molecules [BR:hsa04090]
    942 (CD86)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   942 (CD86)
CD molecules [BR:hsa04090]
 Proteins
  942 (CD86)
SSDB
Motif
Pfam: V-set Ig_2 Ig_3 LAX I-set Psg1 C2-set_3 DUF4381
Other DBs
NCBI-GeneID: 942
NCBI-ProteinID: NP_787058
OMIM: 601020
HGNC: 1705
Ensembl: ENSG00000114013
UniProt: P42081 A8K632
Structure
LinkDB
Position
3:122055362..122121136
AA seq 329 aa
MDPQCTMGLSNILFVMAFLLSGAAPLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQ
ENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGM
IRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTI
EYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQ
PPPDHIPWITAVLPTVIICVMVFCLILWKWKKKKRPRNSYKCGTNTMEREESEQTKKREK
IHIPERSDEAQRVFKSSKTSSCDKSDTCF
NT seq 990 nt   +upstreamnt  +downstreamnt
atggatccccagtgcactatgggactgagtaacattctctttgtgatggccttcctgctc
tctggtgctgctcctctgaagattcaagcttatttcaatgagactgcagacctgccatgc
caatttgcaaactctcaaaaccaaagcctgagtgagctagtagtattttggcaggaccag
gaaaacttggttctgaatgaggtatacttaggcaaagagaaatttgacagtgttcattcc
aagtatatgggccgcacaagttttgattcggacagttggaccctgagacttcacaatctt
cagatcaaggacaagggcttgtatcaatgtatcatccatcacaaaaagcccacaggaatg
attcgcatccaccagatgaattctgaactgtcagtgcttgctaacttcagtcaacctgaa
atagtaccaatttctaatataacagaaaatgtgtacataaatttgacctgctcatctata
cacggttacccagaacctaagaagatgagtgttttgctaagaaccaagaattcaactatc
gagtatgatggtgttatgcagaaatctcaagataatgtcacagaactgtacgacgtttcc
atcagcttgtctgtttcattccctgatgttacgagcaatatgaccatcttctgtattctg
gaaactgacaagacgcggcttttatcttcacctttctctatagagcttgaggaccctcag
cctcccccagaccacattccttggattacagctgtacttccaacagttattatatgtgtg
atggttttctgtctaattctatggaaatggaagaagaagaagcggcctcgcaactcttat
aaatgtggaaccaacacaatggagagggaagagagtgaacagaccaagaaaagagaaaaa
atccatatacctgaaagatctgatgaagcccagcgtgtttttaaaagttcgaagacatct
tcatgcgacaaaagtgatacatgtttttaa

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