KEGG   PATHWAY: ko00254
Entry
ko00254                     Pathway                                
Name
Aflatoxin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
ko00254  Aflatoxin biosynthesis
ko00254

Module
M00937  Aflatoxin biosynthesis, malonyl-CoA => aflatoxin B1 [PATH:ko00254]
Other DBs
GO: 0045122
Orthology
K01946  ACACB; acetyl-CoA carboxylase / biotin carboxylase 2 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K11262  ACACA; acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14 2.1.3.15]
K15316  PKSA; noranthrone synthase [EC:2.3.1.221]
K17643  HYPC; noranthrone monooxygenase [EC:1.13.12.20]
K17644  AFLD, NOR-1; norsolorinic acid ketoreductase [EC:1.1.1.349]
K17645  AVNA, CYP60A1; averantin hydroxylase [EC:1.14.14.116]
K17646  VBS; 5'-oxoaverantin cyclase / versicolorin B synthase [EC:4.2.1.142 4.2.1.143]
K17647  VRDA; versiconal hemiacetal acetate reductase [EC:1.1.1.353]
K17648  ESTA; versiconal hemiacetal acetate esterase [EC:3.1.1.94]
K17649  OMTB, dmtA; demethylsterigmatocystin 6-O-methyltransferase [EC:2.1.1.109]
K17650  OMTA; sterigmatocystin 8-O-methyltransferase [EC:2.1.1.110]
K17651  ORDA, CYP64A; aflatoxin B synthase [EC:1.14.14.117]
K17652  ADHA; 5'-hydroxyaverantin dehydrogenase [EC:1.1.1.352]
K24438  AFLN, STCS, CYP59A1; sterigmatocystin biosynthesis cytochrome P450 monooxygenase
K24439  STCL, CYP60B1; versicolorin B desaturase
K24440  STCB, CYP62A1; averufin monooxygenase
K24855  STCW; hydroxyversicolorone monooxygenase
K24856  AFLM; NADPH-dependent reductase
K24857  AFLX; oxidoreductase AflX
K24858  AFLY; oxidoreductase AflY
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00961  Sterigmatocystin
C03683  6-Demethylsterigmatocystin
C03686  O-Methylsterigmatocystin
C03944  Dihydro-O-methylsterigmatocystin
C06800  Aflatoxin B1
C16753  Aflatoxin B2
C16754  Aflatoxin G2
C16755  Aflatoxin G1
C20444  Dihydrodemethylsterigmatocystin
C20445  Dihydrosterigmatocystin
C20452  Norsolorinic acid
C20453  Norsolorinic acid anthrone
C20499  (1'S)-Averantin
C20500  (1'S,5'S)-5'-Hydroxyaverantin
C20501  (1'S,5'R)-5'-Hydroxyaverantin
C20502  5'-Oxoaverantin
C20503  1'-Hydroxyversicolorone
C20504  Versicolorone
C20505  Versiconal hemiacetal acetate
C20506  Versiconol acetate
C20507  Versiconal
C20508  Versiconol
C20574  (1'S,5'S)-Averufin
C20575  Versicolorin B
C20583  Versicolorin A
Reference
PMID:23202305
  Authors
Yu J
  Title
Current understanding on aflatoxin biosynthesis and future perspective in reducing aflatoxin contamination.
  Journal
Toxins (Basel) 4:1024-57 (2012)
DOI:10.3390/toxins4111024
Reference
PMID:15022028
  Authors
Yabe K, Nakajima H
  Title
Enzyme reactions and genes in aflatoxin biosynthesis.
  Journal
Appl Microbiol Biotechnol 64:745-55 (2004)
DOI:10.1007/s00253-004-1566-x
Reference
PMID:22069531
  Authors
Ehrlich KC
  Title
Predicted roles of the uncharacterized clustered genes in aflatoxin biosynthesis.
  Journal
Toxins (Basel) 1:37-58 (2009)
DOI:10.3390/toxins1010037
Reference
PMID:20332208
  Authors
Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC
  Title
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 107:6246-51 (2010)
DOI:10.1073/pnas.0913531107
Reference
PMID:15932995
  Authors
Sakuno E, Wen Y, Hatabayashi H, Arai H, Aoki C, Yabe K, Nakajima H
  Title
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 71:2999-3006 (2005)
DOI:10.1128/AEM.71.6.2999-3006.2005
Reference
PMID:19211038
  Authors
Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K
  Title
Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster.
  Journal
Fungal Genet Biol 46:221-31 (2009)
DOI:10.1016/j.fgb.2008.12.005

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