PATHWAY: ko00280 Help Entry ko00280                     Pathway                                 Name Valine, leucine and isoleucine degradation Class Metabolism; Amino acid metabolism BRITE hierarchy Pathway map ko00280   Valine, leucine and isoleucine degradation Module M00036   Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:ko00280] M00741   Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:ko00280] Other DBs GO:  0006550 0006552 0006574 Orthology K00020   HIBADH, mmsB; 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] K00022   HADH; 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] K00128   ALDH; aldehyde dehydrogenase (NAD+) [EC:1.2.1.3] K00140   mmsA, iolA, ALDH6A1; malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase [EC:1.2.1.18 1.2.1.27] K00149   ALDH9A1; aldehyde dehydrogenase family 9 member A1 [EC:1.2.1.47 1.2.1.3] K00157   AOX; aldehyde oxidase [EC:1.2.3.1] K00166   BCKDHA, bkdA1; 2-oxoisovalerate dehydrogenase E1 component subunit alpha [EC:1.2.4.4] K00167   BCKDHB, bkdA2; 2-oxoisovalerate dehydrogenase E1 component subunit beta [EC:1.2.4.4] K00186   vorA; 2-oxoisovalerate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.7] K00187   vorB; 2-oxoisovalerate ferredoxin oxidoreductase beta subunit [EC:1.2.7.7] K00188   vorD; 2-oxoisovalerate ferredoxin oxidoreductase delta subunit [EC:1.2.7.7] K00189   vorG, porG; 2-oxoisovalerate/pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.7 1.2.7.1] K00248   ACADS, bcd; butyryl-CoA dehydrogenase [EC:1.3.8.1] K00249   ACADM, acd; acyl-CoA dehydrogenase [EC:1.3.8.7] K00253   IVD; isovaleryl-CoA dehydrogenase [EC:1.3.8.4] K00263   E1.4.1.9; leucine dehydrogenase [EC:1.4.1.9] K00271   vdh; valine dehydrogenase (NAD+) [EC:1.4.1.23] K00382   DLD, lpd, pdhD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] K00626   ACAT, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] K00632   fadA, fadI; acetyl-CoA acyltransferase [EC:2.3.1.16] K00822   E2.6.1.18; beta-alanine--pyruvate transaminase [EC:2.6.1.18] K00826   E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42] K00827   AGXT2; alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase [EC:2.6.1.44 2.6.1.40] K01027   OXCT; 3-oxoacid CoA-transferase [EC:2.8.3.5] K01028   scoA; 3-oxoacid CoA-transferase subunit A [EC:2.8.3.5] K01029   scoB; 3-oxoacid CoA-transferase subunit B [EC:2.8.3.5] K01640   HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] K01641   HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] K01692   paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17] K01782   fadJ; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3] K01825   fadB; 3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8] K01847   MUT; methylmalonyl-CoA mutase [EC:5.4.99.2] K01848   E5.4.99.2A, mcmA1; methylmalonyl-CoA mutase, N-terminal domain [EC:5.4.99.2] K01849   E5.4.99.2B, mcmA2; methylmalonyl-CoA mutase, C-terminal domain [EC:5.4.99.2] K01907   AACS, acsA; acetoacetyl-CoA synthetase [EC:6.2.1.16] K01964   K01964; acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] K01965   PCCA; propionyl-CoA carboxylase alpha subunit [EC:6.4.1.3] K01966   PCCB; propionyl-CoA carboxylase beta subunit [EC:6.4.1.3 2.1.3.15] K01968   MCCC1, accA1; 3-methylcrotonyl-CoA carboxylase alpha subunit [EC:6.4.1.4] K01969   MCCC2, accD1; 3-methylcrotonyl-CoA carboxylase beta subunit [EC:6.4.1.4] K03334   IL4I1; L-amino-acid oxidase [EC:1.4.3.2] K05605   HIBCH; 3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] K05606   MCEE, epi; methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] K05607   AUH; methylglutaconyl-CoA hydratase [EC:4.2.1.18] K07250   gabT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase / 5-aminovalerate transaminase [EC:2.6.1.19 2.6.1.22 2.6.1.48] K07508   ACAA2; acetyl-CoA acyltransferase 2 [EC:2.3.1.16] K07509   HADHB; acetyl-CoA acyltransferase [EC:2.3.1.16] K07511   ECHS1; enoyl-CoA hydratase [EC:4.2.1.17] K07513   ACAA1; acetyl-CoA acyltransferase 1 [EC:2.3.1.16] K07514   EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8] K07515   HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211] K08683   HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178] K09478   ACADSB; short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] K09699   DBT, bkdB; 2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase) [EC:2.3.1.168] K11263   bccA, pccA, accA3; acetyl-CoA/propionyl-CoA/long-chain acyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14] K11381   bkdA; 2-oxoisovalerate dehydrogenase E1 component [EC:1.2.4.4] K11410   acdH; short-chain 2-methylacyl-CoA dehydrogenase [EC:1.3.8.5] K11538   ACAD8; isobutyryl-CoA dehydrogenase [EC:1.3.99.-] K13524   ABAT; 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22] K13766   liuC; methylglutaconyl-CoA hydratase [EC:4.2.1.18] K14085   ALDH7A1; aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3] K15036   K15036; acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3 2.1.3.15] K15037   K15037; biotin carboxyl carrier protein K18472   accD6; acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K18660   ACSF3; malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] K18661   matB; malonyl-CoA/methylmalonyl-CoA synthetase [EC:6.2.1.76 6.2.1.-] K19312   pccB; acetyl-CoA/propionyl-CoA carboxylase carboxyl transferase subunit [EC:6.4.1.2 6.4.1.3 2.1.3.15] K22568   pccX; acetyl-CoA/propionyl-CoA carboxylase, PccX subunit [EC:6.4.1.2 6.4.1.3] K23146   HPD1; 3-hydroxyisobutyrate/3-hydroxypropionate dehydrogenase K27094   accD5; propionyl-CoA/long-chain acyl-CoA carboxylase carboxyl transferase subunit K27095   accE5, accE; acyl-CoA carboxylase epsilon subunit Compound C00024   Acetyl-CoA C00068   Thiamin diphosphate C00091   Succinyl-CoA C00100   Propanoyl-CoA C00123   L-Leucine C00141   3-Methyl-2-oxobutanoic acid C00164   Acetoacetate C00183   L-Valine C00233   4-Methyl-2-oxopentanoate C00332   Acetoacetyl-CoA C00349   2-Methyl-3-oxopropanoate C00356   (S)-3-Hydroxy-3-methylglutaryl-CoA C00407   L-Isoleucine C00630   2-Methylpropanoyl-CoA C00671   (S)-3-Methyl-2-oxopentanoic acid C00683   (S)-Methylmalonyl-CoA C01205   (R)-3-Amino-2-methylpropanoate C01213   (R)-Methylmalonyl-CoA C02170   Methylmalonate C02939   3-Methylbutanoyl-CoA C03069   3-Methylcrotonyl-CoA C03231   3-Methylglutaconyl-CoA C03284   L-3-Aminoisobutanoate C03344   2-Methylacetoacetyl-CoA C03345   2-Methylbut-2-enoyl-CoA C03460   2-Methylprop-2-enoyl-CoA C04405   (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA C05996   Branched chain fatty acid C05998   3-Hydroxyisovaleryl-CoA C06000   (S)-3-Hydroxyisobutyryl-CoA C06001   (S)-3-Hydroxyisobutyrate C06002   (S)-Methylmalonate semialdehyde C15972   Enzyme N6-(lipoyl)lysine C15973   Enzyme N6-(dihydrolipoyl)lysine C15974   3-Methyl-1-hydroxybutyl-ThPP C15975   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine C15976   2-Methyl-1-hydroxypropyl-ThPP C15977   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine C15978   2-Methyl-1-hydroxybutyl-ThPP C15979   [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine C15980   (S)-2-Methylbutanoyl-CoA C20827   3-Hydroxyisovalerate Related pathway ko00020   Citrate cycle (TCA cycle) ko00240   Pyrimidine metabolism ko00290   Valine, leucine and isoleucine biosynthesis ko00522   Biosynthesis of 12-, 14- and 16-membered macrolides ko00640   Propanoate metabolism ko00900   Terpenoid backbone biosynthesis ko01056   Biosynthesis of type II polyketide backbone

DBGET integrated database retrieval system