KEGG PATHWAY: lbi00260

PATHWAY: lbi00260

Entry

lbi00260                    Pathway

Name

Glycine, serine and threonine metabolism - Leptospira biflexa serovar Patoc Patoc 1 (Paris)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

lbi00260

Glycine, serine and threonine metabolism

Module

lbi_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:lbi00260]

lbi_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:lbi00260]

lbi_M00621

Glycine cleavage system [PATH:lbi00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Leptospira biflexa serovar Patoc Patoc 1 (Paris) [GN:lbi]

Gene

LEPBI_I0064

hom; Homoserine dehydrogenase (HDH) [KO:K00003] [EC:1.1.1.3]

LEPBI_I0187

lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]

LEPBI_I0259

thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]

LEPBI_I0498

gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]

LEPBI_I0832

serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

LEPBI_I1006

glyA; Serine hydroxymethyltransferase (Serine methylase; SHMT) [KO:K00600] [EC:2.1.2.1]

LEPBI_I1057

lpdA1; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

LEPBI_I1140

thrB; Homoserine kinase (HSK; HK) [KO:K00872] [EC:2.7.1.39]

LEPBI_I1320

pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

LEPBI_I1590

ilvA; Threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]

LEPBI_I1899

serA2; D-3-phosphoglycerate dehydrogenase (PGDH) [KO:K00058] [EC:1.1.1.95 1.1.1.399]

LEPBI_I2005

serA1; D-3-phosphoglycerate dehydrogenase (PGDH) [KO:K00058] [EC:1.1.1.95 1.1.1.399]

LEPBI_I2366

serC; Phosphoserine aminotransferase (PSAT) [KO:K00831] [EC:2.6.1.52]

LEPBI_I2456

[KO:K11529] [EC:2.7.1.165]

LEPBI_I2607

trpA; Tryptophan synthase alpha protein [KO:K01695] [EC:4.2.1.20]

LEPBI_I2608

trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]

LEPBI_I2656

[KO:K00130] [EC:1.2.1.8]

LEPBI_I2919

lpdA3; Dihydrolipoyl dehydrogenase (E3 component of alpha keto acid dehydrogenase complexes; Dihydrolipoamide dehydrogenase) [KO:K00382] [EC:1.8.1.4]

LEPBI_I3188

gcvT; Aminomethyltransferase (Glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]

LEPBI_I3189

gcvH; Glycine cleavage system H protein [KO:K02437]

LEPBI_I3190

gcvP; Glycine dehydrogenase [decarboxylating] (Glycine cleavage system P protein) [KO:K00281] [EC:1.4.4.2]

LEPBI_II0275

asd; Aspartate semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

C23135

(2S,3S)-2-Acetamido-3-hydroxy-4-aminobutyrate

C23136

4-Amino-L-allothreonine

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721