KEGG   PATHWAY: lil00290
Entry
lil00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Leptospira interrogans serovar Lai 56601
Class
Metabolism; Amino acid metabolism
Pathway map
lil00290  Valine, leucine and isoleucine biosynthesis
lil00290

Module
lil_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:lil00290]
lil_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:lil00290]
lil_M00535  Isoleucine biosynthesis, pyruvate => 2-oxobutanoate [PATH:lil00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Leptospira interrogans serovar Lai 56601 [GN:lil]
Gene
LA_2350  leuA; isopropylmalate/homocitrate/citramalate synthase [KO:K09011] [EC:2.3.3.21]
LA_2095  leuC; isopropylmalate isomerase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
LA_2096  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
LA_2152  leuB; isocitrate/isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
LA_2570  ilvB; acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
LA_2569  ilvH; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
LA_4242  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
LA_2959  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
LA_4360  ilvE; putative branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
LA_0171  valine--pyruvate aminotransferase [KO:K00835] [EC:2.6.1.66]
LA_0469  leuA; isopropylmalate/homocitrate/citramalate synthase [KO:K01649] [EC:2.3.3.13]
LA_2202  leuA; isopropylmalate/homocitrate/citramalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
lil00260  Glycine, serine and threonine metabolism
lil00280  Valine, leucine and isoleucine degradation
lil00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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