KEGG PATHWAY: lil00260

PATHWAY: lil00260

Entry

lil00260                    Pathway

Name

Glycine, serine and threonine metabolism - Leptospira interrogans serovar Lai 56601

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

lil00260

Glycine, serine and threonine metabolism

Module

lil_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:lil00260]

lil_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:lil00260]

lil_M00621

Glycine cleavage system [PATH:lil00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Leptospira interrogans serovar Lai 56601 [GN:lil]

Gene

LA_0693

lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]

LB_355

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

LA_3638

thrA; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

LA_2134

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

LA_3747

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

LA_1409

glyA; glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

LA_2527

gckA; glycerate kinase [KO:K11529] [EC:2.7.1.165]

LA_0439

gpmI; phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]

LA_1629

serA; phosphoglycerate dehydrogenase and related dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

LA_1911

serA; phosphoglycerate dehydrogenase and related dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

LA_0366

serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

LA_2145

serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

LA_0360

gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

LA_0362

gcvT; glycine cleavage T protein [KO:K00605] [EC:2.1.2.10]

LA_1223

lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

LA_2886

lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

LA_0361

gcvH; glycine cleavage system H protein [KO:K02437]

LA_1451

pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]

LA_3288

trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]

LA_3289

trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721