KEGG   PATHWAY: mbb00290
Entry
mbb00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2
Class
Metabolism; Amino acid metabolism
Pathway map
mbb00290  Valine, leucine and isoleucine biosynthesis
mbb00290

Module
mbb_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mbb00290]
mbb_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mbb00290]
mbb_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:mbb00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Mycobacterium tuberculosis variant bovis BCG Pasteur 1173P2 [GN:mbb]
Gene
BCG_0226c  ilvD; Probable dihydroxy-acid dehydratase ilvD (DAD) [KO:K01687] [EC:4.2.1.9]
BCG_0376c  aspC; Probable aspartate aminotransferase aspC [KO:K14260] [EC:2.6.1.66 2.6.1.2]
BCG_1611  ilvA; Probable threonine dehydratase ilvA [KO:K01754] [EC:4.3.1.19]
BCG_2226c  ilvE; Probable branched-chain amino acid transaminase ilvE [KO:K00826] [EC:2.6.1.42]
BCG_3008c  leuD; Probable 3-isopropylmalate dehydratase (small subunit) leuD [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BCG_3009c  leuC; Probable 3-isopropylmalate dehydratase (large subunit) leuC [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BCG_3016c  leuB; 3-isopropylmalate dehydrogenase leuB [KO:K00052] [EC:1.1.1.85]
BCG_3023c  ilvC; Probable ketol-acid reductoisomerase ilvC [KO:K00053] [EC:1.1.1.86]
BCG_3024c  ilvN; Probable acetolactate synthase (small subunit) ilvN [KO:K01653] [EC:2.2.1.6]
BCG_3025c  ilvB1; Probable acetolactate synthase (large subunit) ilvB1 [KO:K01652] [EC:2.2.1.6]
BCG_3535c  ilvB2; Probable acetolactate synthase (large subunit) ilvB2 [KO:K01652] [EC:2.2.1.6]
BCG_3573c  ilvX; Probable acetohydroxyacid synthase ilvX [KO:K01652] [EC:2.2.1.6]
BCG_3770  leuA; 2-isopropylmalate synthase leuA [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
mbb00260  Glycine, serine and threonine metabolism
mbb00280  Valine, leucine and isoleucine degradation
mbb00620  Pyruvate metabolism
KO pathway
ko00290   

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