KEGG   PATHWAY: mcha04148
Entry
mcha04148                   Pathway                                
Name
Efferocytosis - Momordica charantia (bitter melon)
Class
Cellular Processes; Transport and catabolism
Pathway map
mcha04148  Efferocytosis
mcha04148

Organism
Momordica charantia (bitter melon) [GN:mcha]
Gene
111005059  [KO:K05853] [EC:7.2.2.10]
111006275  [KO:K14802] [EC:7.6.2.1]
111006285  [KO:K14802] [EC:7.6.2.1]
111006544  [KO:K07887]
111006918  [KO:K04392]
111007126  [KO:K20180]
111007902  [KO:K07897]
111008226  [KO:K20183]
111010257  [KO:K20182]
111011006  [KO:K04392]
111011098  [KO:K20179]
111011857  [KO:K00411] [EC:7.1.1.8]
111011937  [KO:K00411] [EC:7.1.1.8]
111012384  [KO:K04718] [EC:2.7.1.91]
111012414  [KO:K04392]
111012580  [KO:K20177]
111012759  [KO:K07887]
111013267  [KO:K26935]
111013881  [KO:K14802] [EC:7.6.2.1]
111013904  [KO:K01581] [EC:4.1.1.17]
111013933  [KO:K01581] [EC:4.1.1.17]
111013938  [KO:K20178]
111013993  [KO:K01581] [EC:4.1.1.17]
111013998  [KO:K04392]
111014457  [KO:K04392]
111014832  [KO:K04392]
111015211  [KO:K08057]
111015424  [KO:K04392]
111015769  [KO:K26935]
111016135  [KO:K04392]
111016771  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111016841  [KO:K20181]
111017352  [KO:K01052] [EC:3.1.1.13]
111017353  [KO:K01052] [EC:3.1.1.13]
111018041  [KO:K26935]
111018074  [KO:K01052] [EC:3.1.1.13]
111018618  [KO:K07897]
111018799  [KO:K17398] [EC:2.1.1.37]
111019119  [KO:K14802] [EC:7.6.2.1]
111019873  [KO:K23678]
111020519  [KO:K20184]
111021471  [KO:K01052] [EC:3.1.1.13]
111021852  [KO:K04368] [EC:2.7.12.2]
111022605  [KO:K23678]
111022808  [KO:K01476] [EC:3.5.3.1]
111023240  [KO:K07897]
111023298  [KO:K08057]
111023545  [KO:K04371] [EC:2.7.11.24]
111024251  [KO:K04392]
111025529  [KO:K07897]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
mcha00010  Glycolysis / Gluconeogenesis
mcha04145  Phagosome
KO pathway
ko04148   

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