KEGG   PATHWAY: ko04148
Entry
ko04148                     Pathway                                
Name
Efferocytosis
Class
Cellular Processes; Transport and catabolism
Pathway map
ko04148  Efferocytosis
ko04148

Orthology
K00411  UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00460  ALOX15; arachidonate 15-lipoxygenase [EC:1.13.11.33]
K00461  ALOX5; arachidonate 5-lipoxygenase [EC:1.13.11.34]
K01052  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [EC:3.1.1.13]
K01370  CASP1; caspase 1 [EC:3.4.22.36]
K01476  rocF, arg; arginase [EC:3.5.3.1]
K01581  E4.1.1.17, ODC1, speC, speF; ornithine decarboxylase [EC:4.1.1.17]
K02187  CASP3; caspase 3 [EC:3.4.22.56]
K03443  PANX1; pannexin 1
K03908  PROS1; protein S
K03986  C1QA; complement C1q subcomponent subunit A
K03987  C1QB; complement C1q subcomponent subunit B
K03988  C1QG; complement C1q subcomponent subunit C
K04192  CX3CR1; CX3C chemokine receptor 1
K04259  PTGER2; prostaglandin E receptor 2
K04261  PTGER4; prostaglandin E receptor 4
K04269  P2RY2; P2Y purinoceptor 2
K04272  P2RY6; P2Y purinoceptor 6
K04288  S1PR1, EDG1, CD363; sphingosine 1-phosphate receptor 1
K04298  P2RY12; P2Y purinoceptor 12
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04397  CASP7; caspase 7 [EC:3.4.22.60]
K04438  CRK, CRKII; C-crk adapter molecule crk
K04441  P38; p38 MAP kinase [EC:2.7.11.24]
K04443  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]
K04446  NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
K04447  JAK2; Janus kinase 2 [EC:2.7.10.2]
K04459  DUSP, MKP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]
K04504  NR1C2, PPARD; peroxisome proliferator-activated receptor delta
K04515  CAMK2; calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]
K04550  LRP1, CD91; low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor)
K04596  ADGRB1, BAI1; adhesion G protein-coupled receptor B1
K04718  SPHK; sphingosine kinase [EC:2.7.1.91]
K05079  EPOR; erythropoietin receptor
K05115  AXL, UFO; AXL receptor tyrosine kinase [EC:2.7.10.1]
K05116  TYRO3, RSE; TYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]
K05117  MERTK, MER; c-mer proto-oncogene tyrosine kinase [EC:2.7.10.1]
K05437  EPO; erythropoietin
K05443  IL10, CSIF; interleukin 10
K05464  GAS6; growth arrest-specific 6
K05508  CX3CL1, NTT; C-X3-C motif chemokine 1
K05641  ABCA1; ATP-binding cassette, subfamily A (ABC1), member 1
K05697  PTPN6, SHP1; tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
K05725  PTK2, FAK; focal adhesion kinase 1 [EC:2.7.10.2]
K05726  BCAR1, CAS; breast cancer anti-estrogen resistance 1
K05853  ATP2A; P-type Ca2+ transporter type 2A [EC:7.2.2.10]
K05870  CREB1; cyclic AMP-responsive element-binding protein 1
K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
K06129  LYPLA3; lysophospholipase III [EC:3.1.1.5]
K06259  CD36; CD36 antigen
K06266  CD47; CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
K06469  CD24; CD24 antigen
K06471  PECAM1, CD31; platelet/endothelial cell adhesion molecule
K06487  ITGAV, CD51; integrin alpha V
K06493  ITGB3, CD61; integrin beta 3
K06535  BSG, CD147; basigin
K06551  SIRPA_B1_G, CD172; signal-regulatory protein alpha/beta1/gamma
K06588  ITGB5; integrin beta 5
K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81]
K06749  SIGLEC10; sialic acid binding Ig-like lectin 10
K06834  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [EC:3.4.24.-]
K07293  PTPN11, SHP2; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
K07299  SLC2A1, GLUT1; MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1
K07881  RAB14; Ras-related protein Rab-14
K07887  RAB5A; Ras-related protein Rab-5A
K07888  RAB5B; Ras-related protein Rab-5B
K07889  RAB5C; Ras-related protein Rab-5C
K07897  RAB7A; Ras-related protein Rab-7A
K07898  RAB7B; Ras-related protein Rab-7B
K07909  RAB17; Ras-related protein Rab-17
K08057  CALR; calreticulin
K08179  SLC16A1; MFS transporter, MCT family, solute carrier family 16 (monocarboxylic acid transporters), member 1
K08268  HIF1A; hypoxia-inducible factor 1 alpha
K08426  GPR132, G2A; G protein-coupled receptor 132
K08524  RXRA, NR2B1; retinoid X receptor alpha
K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
K08535  NR1H2, LXRB; liver X receptor beta
K08536  NR1H3, LXRA; liver X receptor alpha
K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]
K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
K09355  PBX1; pre-B-cell leukemia transcription factor 1
K10048  CEBPB; CCAAT/enhancer binding protein (C/EBP), beta
K10223  CH25H; cholesterol 25-hydroxylase [EC:1.14.99.38]
K11411  SIRT1, SIR2L1; NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K12366  ELMO1, CED12; engulfment and cell motility protein 1
K13302  SGK1; serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
K13375  TGFB1; transforming growth factor beta-1
K13708  DOCK1; dedicator of cytokinesis protein 1
K14802  DRS2, ATP8A; phospholipid-transporting ATPase [EC:7.6.2.1]
K16343  PLA2G6, IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4]
K16857  THBS1; thrombospondin 1
K17253  MFGE8; lactadherin
K17332  NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
K17333  NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
K17334  NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
K17398  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
K19013  STAB2, HARE; stabilin-2
K19020  STAB1; stabilin-1
K19480  ANO5, GDD1, TMEM16E; anoctamin-5
K19498  ANO3, TMEM16C; anoctamin-3
K19499  ANO4, TMEM16D; anoctamin-4
K19500  ANO6, TMEM16F; anoctamin-6
K19501  ANO7, NGEP, TMEM16G; anoctamin-7
K19503  ANO9, TMEM16J; anoctamin-9
K19523  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [EC:2.3.1.21]
K19524  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [EC:2.3.1.21]
K19722  AGER, RAGE; receptor for advanced glycosylation end products
K20177  VPS3, TGFBRAP1; vacuolar protein sorting-associated protein 3
K20178  VPS8; vacuolar protein sorting-associated protein 8
K20179  VPS11, PEP5; vacuolar protein sorting-associated protein 11
K20180  VPS16; vacuolar protein sorting-associated protein 16
K20181  VPS18, PEP3; vacuolar protein sorting-associated protein 18
K20182  VPS33A; vacuolar protein sorting-associated protein 33A
K20183  VPS39, VAM6; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
K20184  VPS41; vacuolar protein sorting-associated protein 41
K20413  HAVCR1, CD365; hepatitis A virus cellular receptor 1
K20414  HAVCR2, CD366; hepatitis A virus cellular receptor 2
K23285  GULP1, CED6; PTB domain-containing engulfment adapter protein 1
K23678  PQLC2, SLC66A1, LAAT1; solute carrier family 66 (lysosomal lysine-arginine transporter), member 1
K24068  MEGF10_11; multiple epidermal growth factor-like domains protein 10/11
K24318  SCARF1; scavenger receptor class F member 1
K26811  XKR4_6_7; XK-related protein 4/6/7
K26813  XKR8; XK-related protein 8
K26814  XKR9; XK-related protein 9
K26934  ATP11; phospholipid-transporting ATPase
K26935  TMEM30, CDC50; cell cycle control protein 50
K26936  TIMD4, TIM4; T-cell immunoglobulin and mucin domain-containing protein 4
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko04140  Autophagy - animal
ko04145  Phagosome

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