KEGG PATHWAY: mcoc03450

PATHWAY: mcoc03450

Entry

mcoc03450                   Pathway

Name

Non-homologous end-joining - Mastomys coucha (southern multimammate mouse)

Description

Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.

Class

Genetic Information Processing; Replication and repair

Pathway map

mcoc03450

Non-homologous end-joining

Other DBs

GO:

0006303

Organism

Mastomys coucha (southern multimammate mouse) [GN:mcoc]

Gene

116068887

Lig4; DNA ligase 4 isoform X1 [KO:K10777] [EC:6.5.1.1]

116070532

Polm; DNA-directed DNA/RNA polymerase mu isoform X1 [KO:K03513] [EC:2.7.7.7]

116072079

Mre11; double-strand break repair protein MRE11 [KO:K10865]

116076506

Xrcc6; X-ray repair cross-complementing protein 6 [KO:K10884]

116077478

Rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]

116082664

Dclre1c; LOW QUALITY PROTEIN: protein artemis [KO:K10887] [EC:3.1.-.-]

116083722

Xrcc4; DNA repair protein XRCC4 [KO:K10886]

116085621

Prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]

116088549

Xrcc5; X-ray repair cross-complementing protein 5 isoform X1 [KO:K10885]

116088591

Nhej1; non-homologous end-joining factor 1 isoform X1 [KO:K10980]

116101174

Dntt; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:2.7.7.31]

116103548

Fen1; flap endonuclease 1 [KO:K04799] [EC:3.1.-.-]

116103922

Poll; DNA polymerase lambda [KO:K03512] [EC:2.7.7.7 4.2.99.-]

Reference

PMID:16971555

Authors

Gennery AR.

Title

Primary immunodeficiency syndromes associated with defective DNA double-strand break repair.

Journal

Br Med Bull 77-78:71-85 (2006)
DOI:10.1093/bmb/ldl006

Reference

PMID:17589524

Authors

Zhang Y, Hefferin ML, Chen L, Shim EY, Tseng HM, Kwon Y, Sung P, Lee SE, Tomkinson AE.

Title

Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination.

Journal

Nat Struct Mol Biol 14:639-46 (2007)
DOI:10.1038/nsmb1261

Reference

PMID:16895466

Authors

Wyman C, Kanaar R.

Title

DNA double-strand break repair: all's well that ends well.

Journal

Annu Rev Genet 40:363-83 (2006)
DOI:10.1146/annurev.genet.40.110405.090451

Reference

PMID:15578053

Authors

Weller GR, Brandt VL, Roth DB.

Title

Doing more with less in bacterial DNA repair.

Journal

Nat Struct Mol Biol 11:1158-9 (2004)
DOI:10.1038/nsmb1204-1158

Reference

PMID:12215643

Authors

Weller GR, Kysela B, Roy R, Tonkin LM, Scanlan E, Della M, Devine SK, Day JP, Wilkinson A, d'Adda di Fagagna F, Devine KM, Bowater RP, Jeggo PA, Jackson SP, Doherty AJ.

Title

Identification of a DNA nonhomologous end-joining complex in bacteria.

Journal

Science 297:1686-9 (2002)
DOI:10.1126/science.1074584

Reference

PMID:17506672

Authors

Pitcher RS, Brissett NC, Doherty AJ.

Title

Nonhomologous end-joining in bacteria: a microbial perspective.

Journal

Annu Rev Microbiol 61:259-82 (2007)
DOI:10.1146/annurev.micro.61.080706.093354

KO pathway

ko03450

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