KEGG   PATHWAY: mlf04512
Entry
mlf04512                    Pathway                                
Name
ECM-receptor interaction - Myotis lucifugus (little brown bat)
Description
The extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell and tissue structure and function. Specific interactions between cells and the ECM are mediated by transmembrane molecules, mainly integrins and perhaps also proteoglycans, CD36, or other cell-surface-associated components. These interactions lead to a direct or indirect control of cellular activities such as adhesion, migration, differentiation, proliferation, and apoptosis. In addition, integrins function as mechanoreceptors and provide a force-transmitting physical link between the ECM and the cytoskeleton. Integrins are a family of glycosylated, heterodimeric transmembrane adhesion receptors that consist of noncovalently bound alpha- and beta-subunits.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mlf04512  ECM-receptor interaction
mlf04512

Other DBs
GO: 0005201
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102416916  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102417152  SPP1; osteopontin [KO:K06250]
102417236  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
102418373  ITGB7; integrin beta-7 [KO:K06590]
102418832  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
102419199  [KO:K06266]
102419321  NPNT; nephronectin [KO:K06824]
102419595  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102419751  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102419814  LAMC1; laminin subunit gamma-1 [KO:K05635]
102420016  LAMB3; laminin subunit beta-3 [KO:K06244]
102420284  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
102420344  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
102420409  GP6; platelet glycoprotein VI [KO:K06264]
102421464  TNR; tenascin-R [KO:K06252]
102421777  ITGB3; integrin beta-3 [KO:K06493]
102421945  LAMA5; laminin subunit alpha-5 [KO:K06240]
102422404  ITGA8; integrin alpha-8 [KO:K06584]
102422748  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
102423189  FREM1; LOW QUALITY PROTEIN: FRAS1-related extracellular matrix protein 1 [KO:K23380]
102423308  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
102423421  THBS4; thrombospondin-4 [KO:K04659]
102424308  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
102424435  TNC; tenascin isoform X3 [KO:K06252]
102424619  SDC1; LOW QUALITY PROTEIN: syndecan-1 [KO:K06257]
102426340  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102426871  VWF; von Willebrand factor [KO:K03900]
102426930  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102427340  COL2A1; collagen alpha-1(II) chain [KO:K19719]
102427564  GP1BB; LOW QUALITY PROTEIN: platelet glycoprotein Ib beta chain [KO:K06262]
102427655  ITGA7; integrin alpha-7 [KO:K06583]
102427760  VTN; vitronectin [KO:K06251]
102427771  GP9; platelet glycoprotein IX [KO:K06263]
102428301  SV2A; synaptic vesicle glycoprotein 2A [KO:K06258]
102428453  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102428484  SDC4; syndecan-4 isoform X1 [KO:K16338]
102428536  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102428769  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
102429258  FREM2; LOW QUALITY PROTEIN: FRAS1-related extracellular matrix protein 2 [KO:K23380]
102429510  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
102429864  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
102430047  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
102430938  CD36; platelet glycoprotein 4 [KO:K06259]
102431756  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
102432241  HMMR; hyaluronan mediated motility receptor isoform X1 [KO:K06267]
102432339  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102433247  [KO:K06247]
102433733  FRAS1; LOW QUALITY PROTEIN: extracellular matrix protein FRAS1 [KO:K23379]
102434037  LAMA4; laminin subunit alpha-4 [KO:K06241]
102434127  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
102434140  LAMA3; laminin subunit alpha-3 [KO:K06240]
102434163  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
102434229  SV2C; synaptic vesicle glycoprotein 2C isoform X1 [KO:K06258]
102434359  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
102434641  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102434681  LAMC3; laminin subunit gamma-3 [KO:K06247]
102434873  SV2B; synaptic vesicle glycoprotein 2B [KO:K06258]
102435389  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102435863  THBS3; thrombospondin-3 [KO:K04659]
102436416  [KO:K06238]
102436659  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
102437036  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102437320  COMP; cartilage oligomeric matrix protein [KO:K04659]
102437344  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
102438166  LAMB4; laminin subunit beta-4 [KO:K06245]
102438305  LAMC2; laminin subunit gamma-2 [KO:K06246]
102438432  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
102438448  ITGA9; integrin alpha-9 [KO:K06585]
102438476  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
102438984  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102439153  ITGAV; integrin alpha-V [KO:K06487]
102439189  GP5; platelet glycoprotein V [KO:K06260]
102439306  DAG1; dystroglycan [KO:K06265]
102439326  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
102439596  ITGA4; integrin alpha-4 [KO:K06483]
102440246  DSPP; LOW QUALITY PROTEIN: dentin sialophosphoprotein [KO:K23573]
102440437  FN1; fibronectin isoform X7 [KO:K05717]
102440571  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102441094  THBS1; thrombospondin-1 [KO:K16857]
102441473  CD44; CD44 antigen [KO:K06256]
102441901  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102442311  DMP1; dentin matrix acidic phosphoprotein 1 isoform X1 [KO:K23328]
102442455  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102442551  TNN; tenascin-N [KO:K06252]
102442831  IBSP; bone sialoprotein 2 [KO:K06253]
102443143  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102443156  MEPE; matrix extracellular phosphoglycoprotein isoform X1 [KO:K26442]
106694687  [KO:K06240]
111826311  [KO:K06266]
Compound
G10505  Hyaluronic acid
Reference
PMID:11572082
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
DOI:10.1007/s004410100417
Reference
PMID:12921709
  Authors
Reddy KV, Mangale SS.
  Title
Integrin receptors: the dynamic modulators of endometrial function.
  Journal
Tissue Cell 35:260-73 (2003)
DOI:10.1016/S0040-8166(03)00039-9
Reference
PMID:12125070
  Authors
Milner R, Campbell IL.
  Title
The integrin family of cell adhesion molecules has multiple functions within the CNS.
  Journal
J Neurosci Res 69:286-91 (2002)
DOI:10.1002/jnr.10321
Reference
PMID:12796473
  Authors
Cichy J, Pure E.
  Title
The liberation of CD44.
  Journal
J Cell Biol 161:839-43 (2003)
DOI:10.1083/jcb.200302098
Reference
PMID:7698997
  Authors
Elenius K, Jalkanen M.
  Title
Function of the syndecans--a family of cell surface proteoglycans.
  Journal
J Cell Sci 107 ( Pt 11):2975-82 (1994)
Reference
PMID:10617638
  Authors
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS.
  Title
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
  Journal
J Biol Chem 275:451-60 (2000)
DOI:10.1074/jbc.275.1.451
Reference
PMID:15036264
  Authors
Sid B, Sartelet H, Bellon G, El Btaouri H, Rath G, Delorme N, Haye B, Martiny L.
  Title
Thrombospondin 1: a multifunctional protein implicated in the regulation of tumor growth.
  Journal
Crit Rev Oncol Hematol 49:245-58 (2004)
DOI:10.1016/j.critrevonc.2003.09.009
Reference
PMID:15381249
  Authors
Canobbio I, Balduini C, Torti M.
  Title
Signalling through the platelet glycoprotein Ib-V-IX complex.
  Journal
Cell Signal 16:1329-44 (2004)
DOI:10.1016/j.cellsig.2004.05.008
Reference
PMID:11331578
  Authors
Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, Lindhout T, Heemskerk JW, Zirngibl H, Fassler R.
  Title
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen.
  Journal
EMBO J 20:2120-30 (2001)
DOI:10.1093/emboj/20.9.2120
Reference
PMID:12736199
  Authors
Martin PT.
  Title
Dystroglycan glycosylation and its role in matrix binding in skeletal muscle.
  Journal
Glycobiology 13:55R-66R (2003)
DOI:10.1093/glycob/cwg076
Reference
PMID:15229478
  Authors
Toole BP.
  Title
Hyaluronan: from extracellular glue to pericellular cue.
  Journal
Nat Rev Cancer 4:528-39 (2004)
DOI:10.1038/nrc1391
Reference
PMID:12845610
  Authors
Bosman FT, Stamenkovic I.
  Title
Functional structure and composition of the extracellular matrix.
  Journal
J Pathol 200:423-8 (2003)
DOI:10.1002/path.1437
Reference
PMID:29079659
  Authors
van der Ven AT, Vivante A, Hildebrandt F
  Title
Novel Insights into the Pathogenesis of Monogenic Congenital Anomalies of the Kidney and Urinary Tract.
  Journal
J Am Soc Nephrol 29:36-50 (2018)
DOI:10.1681/ASN.2017050561
Related
pathway
mlf04510  Focal adhesion
KO pathway
ko04512   

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