KEGG   PATHWAY: mlf04510
Entry
mlf04510                    Pathway                                
Name
Focal adhesion - Myotis lucifugus (little brown bat)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mlf04510  Focal adhesion
mlf04510

Other DBs
GO: 0005925
Organism
Myotis lucifugus (little brown bat) [GN:mlf]
Gene
102434359  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
102440571  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102427340  COL2A1; collagen alpha-1(II) chain [KO:K19719]
102419751  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102428769  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
102428453  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102420284  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
102443143  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
102416916  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102418832  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
102436416  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
102437036  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102437344  COL6A6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
102434127  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
102434641  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
102419595  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102442455  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102423308  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
102436659  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
102426930  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102421945  LAMA5; laminin subunit alpha-5 [KO:K06240]
106694687  LOW QUALITY PROTEIN: laminin subunit alpha-3-like [KO:K06240]
102434140  LAMA3; laminin subunit alpha-3 [KO:K06240]
102434037  LAMA4; laminin subunit alpha-4 [KO:K06241]
102438476  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
102420016  LAMB3; laminin subunit beta-3 [KO:K06244]
102438166  LAMB4; laminin subunit beta-4 [KO:K06245]
102419814  LAMC1; laminin subunit gamma-1 [KO:K05635]
102438305  LAMC2; laminin subunit gamma-2 [KO:K06246]
102434681  LAMC3; laminin subunit gamma-3 [KO:K06247]
102433247  LOW QUALITY PROTEIN: laminin subunit gamma-3-like [KO:K06247]
102422748  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
102441094  THBS1; thrombospondin-1 [KO:K16857]
102431756  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
102423421  THBS4; thrombospondin-4 [KO:K04659]
102437320  COMP; cartilage oligomeric matrix protein [KO:K04659]
102435863  THBS3; thrombospondin-3 [KO:K04659]
102440437  FN1; fibronectin isoform X7 [KO:K05717]
102417152  SPP1; osteopontin [KO:K06250]
102427760  VTN; vitronectin [KO:K06251]
102442551  TNN; tenascin-N [KO:K06252]
102421464  TNR; tenascin-R [KO:K06252]
102424435  TNC; tenascin isoform X3 [KO:K06252]
102426871  VWF; von Willebrand factor [KO:K03900]
102442831  IBSP; bone sialoprotein 2 [KO:K06253]
102434163  ITGA2; integrin alpha-2 isoform X2 [KO:K06481]
102420344  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
102441901  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102439596  ITGA4; integrin alpha-4 [KO:K06483]
102438432  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
102426340  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102427655  ITGA7; integrin alpha-7 [KO:K06583]
102422404  ITGA8; integrin alpha-8 [KO:K06584]
102438448  ITGA9; integrin alpha-9 [KO:K06585]
102432339  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
102430047  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
102439153  ITGAV; integrin alpha-V [KO:K06487]
102438984  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
102421777  ITGB3; integrin beta-3 [KO:K06493]
102429864  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
102424308  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
102428536  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
102418373  ITGB7; integrin beta-7 [KO:K06590]
102435389  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102437612  EMP2; epithelial membrane protein 2 [KO:K26256]
102422469  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102426780  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102442814  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102418575  PDGFD; platelet-derived growth factor D [KO:K05450]
102424256  EGF; pro-epidermal growth factor [KO:K04357]
102424041  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102426433  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
102438597  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102421300  PGF; placenta growth factor isoform X1 [KO:K16859]
102421161  VEGFD; vascular endothelial growth factor D [KO:K05449]
102438038  VEGFC; vascular endothelial growth factor C [KO:K05449]
102441297  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102417415  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102441579  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102430595  IGF1R; LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102442473  KDR; vascular endothelial growth factor receptor 2 isoform X3 [KO:K05098] [EC:2.7.10.1]
102435209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102417951  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102422327  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102430005  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102441042  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102427788  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102432592  EMP1; epithelial membrane protein 1 isoform X2 [KO:K26255]
102430207  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102427607  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102431969  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
102422264  RHOA; transforming protein RhoA [KO:K04513]
102430746  transforming protein RhoA-like isoform X1 [KO:K04513]
102437258  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
102419225  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
102431516  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102438342  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102436444  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102422575  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102429793  MYL10; myosin regulatory light chain 10 [KO:K12756]
102442553  myosin regulatory light chain 12B isoform X3 [KO:K12757]
102442866  myosin regulatory light chain 12A-like [KO:K12757]
102433527  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
102437203  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102436383  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102429857  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
102417633  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102429955  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
102419496  protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
102421040  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102427404  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102443301  MYLK2; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102416877  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102422006  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4 [KO:K00889] [EC:2.7.1.68]
102422721  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
102426679  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
102425233  actin, cytoplasmic 2 [KO:K05692]
102433374  actin, cytoplasmic 1-like [KO:K05692]
102438585  LOW QUALITY PROTEIN: calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102440413  ACTN4; LOW QUALITY PROTEIN: alpha-actinin-4 [KO:K05699]
102432738  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
102442065  TLN2; talin-2 [KO:K06271]
102432158  TLN1; talin-1 [KO:K06271]
102423871  FLNA; filamin-A [KO:K04437]
102430780  FLNB; filamin-B isoform X1 [KO:K27392]
102427666  PXN; paxillin isoform X1 [KO:K05760]
102419059  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
102423905  ZYX; LOW QUALITY PROTEIN: zyxin [KO:K06273]
102436155  VCL; vinculin [KO:K05700]
102438293  beta-parvin [KO:K06275]
102433970  PARVA; alpha-parvin [KO:K06275]
102431196  PDPK1; LOW QUALITY PROTEIN: 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102443221  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102439923  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102428794  GSK3B; glycogen synthase kinase-3 beta isoform X13 [KO:K03083] [EC:2.7.11.26]
102441147  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
102438932  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102428240  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102419083  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
102442955  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102422649  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102441064  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102433534  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102427890  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102441522  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102429230  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102426106  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102419324  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
102428304  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102417802  VAV1; proto-oncogene vav [KO:K05730]
102441944  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
102435667  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102418852  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102423786  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
102436424  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102438044  PAK3; serine/threonine-protein kinase PAK 3 isoform X4 [KO:K05733] [EC:2.7.11.1]
102420569  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
102443084  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
102431483  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
102439024  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102431239  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
102440736  CRK; adapter molecule crk isoform X1 [KO:K04438]
102420269  CRKL; crk-like protein isoform X1 [KO:K04438]
102443158  LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
102416933  dedicator of cytokinesis protein 1 [KO:K13708]
102417583  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
102418362  RAP1A; ras-related protein Rap-1A [KO:K04353]
102441232  RAP1B; ras-related protein Rap-1b [KO:K07836]
102430582  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102437455  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102418507  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102437415  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102435241  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102440740  CAV1; caveolin-1 [KO:K06278]
102418076  CAV2; LOW QUALITY PROTEIN: caveolin-2 [KO:K12958]
102430890  CAV3; caveolin-3 [KO:K12959]
102422740  FYN; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
102430334  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
102435382  SHC3; LOW QUALITY PROTEIN: SHC-transforming protein 3 [KO:K17448]
102431548  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
102421027  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102442926  SOS1; son of sevenless homolog 1 [KO:K03099]
102437531  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102434453  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102417411  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
102417755  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102422236  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102419846  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102441858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
102422703  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102435083  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102424628  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102424316  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
102436922  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102437980  BAD; bcl2-associated agonist of cell death [KO:K02158]
102432611  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mlf04010  MAPK signaling pathway
mlf04060  Cytokine-cytokine receptor interaction
mlf04070  Phosphatidylinositol signaling system
mlf04110  Cell cycle
mlf04151  PI3K-Akt signaling pathway
mlf04310  Wnt signaling pathway
mlf04512  ECM-receptor interaction
mlf04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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