KEGG   PATHWAY: mmc00984
Entry
mmc00984                    Pathway                                
Name
Steroid degradation - Mycobacterium sp. MCS
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mmc00984  Steroid degradation
mmc00984

Other DBs
GO: 0006707
Organism
Mycobacterium sp. MCS [GN:mmc]
Gene
Mmcs_1170  FAD dependent oxidoreductase [KO:K03333] [EC:1.1.3.6]
Mmcs_4109  3-beta hydroxysteroid dehydrogenase/isomerase [KO:K16045] [EC:1.1.1.145 5.3.3.1]
Mmcs_4572  cytochrome P450 [KO:K15981] [EC:1.14.15.29]
Mmcs_4677  cytochrome P450 [KO:K15981] [EC:1.14.15.29]
Mmcs_2723  putative cytochrome P450 [KO:K15981] [EC:1.14.15.29]
Mmcs_4631  cytochrome P450 [KO:K16046] [EC:1.14.15.28]
Mmcs_4662  fumarate reductase/succinate dehydrogenase flavoprotein-like protein [KO:K05898] [EC:1.3.99.4]
Mmcs_0293  fumarate reductase/succinate dehydrogenase flavoprotein-like protein [KO:K05898] [EC:1.3.99.4]
Mmcs_3784  fumarate reductase/succinate dehydrogenase flavoprotein-like protein [KO:K05898] [EC:1.3.99.4]
Mmcs_0287  fumarate reductase/succinate dehydrogenase flavoprotein-like protein [KO:K05898] [EC:1.3.99.4]
Mmcs_4640  Rieske (2Fe-2S) region [KO:K15982] [EC:1.14.15.30]
Mmcs_0296  Rieske (2Fe-2S) region [KO:K15982] [EC:1.14.15.30]
Mmcs_1788  Rieske (2Fe-2S) region [KO:K15982] [EC:1.14.15.30]
Mmcs_3569  Rieske (2Fe-2S) region [KO:K15982] [EC:1.14.15.30]
Mmcs_0319  ferredoxin [KO:K15983] [EC:1.14.15.30]
Mmcs_4710  ferredoxin [KO:K15983] [EC:1.14.15.30]
Mmcs_3712  ferredoxin [KO:K15983] [EC:1.14.15.30]
Mmcs_4709  Acyl-CoA dehydrogenase, type 2-like protein [KO:K16047] [EC:1.14.14.12]
Mmcs_0318  Acyl-CoA dehydrogenase, type 2-like protein [KO:K16047] [EC:1.14.14.12]
Mmcs_1594  Acyl-CoA dehydrogenase, type 2-like protein [KO:K16047] [EC:1.14.14.12]
Mmcs_4706  flavin reductase-like, FMN-binding protein [KO:K16048] [EC:1.5.1.-]
Mmcs_4707  Glyoxalase/bleomycin resistance protein/dioxygenase [KO:K16049] [EC:1.13.11.25]
Mmcs_0317  Glyoxalase/bleomycin resistance protein/dioxygenase [KO:K16049] [EC:1.13.11.25]
Mmcs_4708  alpha/beta hydrolase fold protein [KO:K16050] [EC:3.7.1.17]
Mmcs_3655  AMP-dependent synthetase and ligase [KO:K18687] [EC:6.2.1.41]
Mmcs_4694  AMP-dependent synthetase and ligase [KO:K18687] [EC:6.2.1.41]
Mmcs_4139  nuclear transport factor 2 [KO:K01822] [EC:5.3.3.1]
Mmcs_4586  nuclear transport factor 2 [KO:K01822] [EC:5.3.3.1]
Mmcs_0302  fumarate reductase/succinate dehydrogenase flavoprotein-like protein [KO:K16051] [EC:1.3.99.5]
Mmcs_0316  fumarate reductase/succinate dehydrogenase flavoprotein-like protein [KO:K16051] [EC:1.3.99.5]
Compound
C00187  Cholesterol
C00280  Androstenedione
C00535  Testosterone
C00599  Cholest-4-en-3-one
C00674  5alpha-Androstane-3,17-dione
C01227  Dehydroepiandrosterone
C04793  3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C04844  3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
C07635  Epiandrosterone
C11354  2-Hydroxy-cis-hex-2,4-dienoate
C14909  9alpha-Hydroxyandrosta-1,4-diene-3,17-dione
C19944  3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C20144  Androsta-1,4-diene-3,17-dione
C20199  3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate
C20252  5-Androstene-3,17-dione
C20838  3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
C20839  (25R)-3-Oxocholest-4-en-26-oate
C21076  Delta4-Dafachronic acid
Reference
PMID:21924910
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009
Reference
PMID:17264217
  Authors
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD
  Title
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
  Journal
Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104
Reference
PMID:22045806
  Authors
Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS
  Title
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
  Journal
J Biol Chem 286:43668-78 (2011)
DOI:10.1074/jbc.M111.313643
Reference
PMID:20889498
  Authors
Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW
  Title
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
  Journal
J Biol Chem 285:38270-82 (2010)
DOI:10.1074/jbc.M110.164293
Reference
PMID:20843794
  Authors
Johnston JB, Ouellet H, Ortiz de Montellano PR
  Title
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
  Journal
J Biol Chem 285:36352-60 (2010)
DOI:10.1074/jbc.M110.161117
Reference
PMID:17630785
  Authors
Yang X, Dubnau E, Smith I, Sampson NS
  Title
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.
  Journal
Biochemistry 46:9058-67 (2007)
DOI:10.1021/bi700688x
Reference
PMID:19875455
  Authors
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD
  Title
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.
  Journal
J Biol Chem 285:434-43 (2010)
DOI:10.1074/jbc.M109.058081
Reference
PMID:19843168
  Authors
Kreit J, Sampson NS
  Title
Cholesterol oxidase: physiological functions.
  Journal
FEBS J 276:6844-56 (2009)
DOI:10.1111/j.1742-4658.2009.07378.x
Reference
PMID:21056662
  Authors
Horinouchi M, Hayashi T, Kudo T
  Title
Steroid degradation in Comamonas testosteroni.
  Journal
J Steroid Biochem Mol Biol 129:4-14 (2012)
DOI:10.1016/j.jsbmb.2010.10.008
Reference
PMID:20554032
  Authors
Horinouchi M, Kurita T, Hayashi T, Kudo T
  Title
Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.
  Journal
J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002
Related
pathway
mmc00100  Steroid biosynthesis
mmc00622  Xylene degradation
KO pathway
ko00984   
LinkDB

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