KEGG   PATHWAY: mmf03013
Entry
mmf03013                    Pathway                                
Name
Nucleocytoplasmic transport - Molossus molossus (Pallas's mastiff bat)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
mmf03013  Nucleocytoplasmic transport
mmf03013

Other DBs
GO: 0050658
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118615173  TNPO2; transportin-2 isoform X1 [KO:K18727]
118615332  XPO7; exportin-7 isoform X1 [KO:K18460]
118615611  THOC3; THO complex subunit 3 isoform X1 [KO:K12880]
118615757  [KO:K12160]
118616243  KPNA7; importin subunit alpha-8 [KO:K15043]
118616550  RANBP17; ran-binding protein 17 [KO:K24115]
118616554  [KO:K24115]
118616924  [KO:K03231]
118617068  KPNA1; importin subunit alpha-5 [KO:K23940]
118617071  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
118617102  KPNA4; importin subunit alpha-3 [KO:K23583]
118617261  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
118617689  NUP210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
118617750  [KO:K23583]
118617796  [KO:K12160]
118617808  NMD3; 60S ribosomal export protein NMD3 [KO:K07562]
118618125  THOC1; THO complex subunit 1 [KO:K12878]
118618490  CSE1L; exportin-2 [KO:K18423]
118618601  SEH1L; LOW QUALITY PROTEIN: nucleoporin SEH1 [KO:K14299]
118618745  NXT1; NTF2-related export protein 1 [KO:K14285]
118618794  RAE1; mRNA export factor isoform X1 [KO:K14298]
118619047  [KO:K12160]
118619092  [KO:K15043]
118619305  EEF1A2; elongation factor 1-alpha 2 [KO:K03231]
118619814  NUP205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
118619991  NUP42; nucleoporin NUP42 [KO:K14321]
118620480  TNPO3; transportin-3 isoform X1 [KO:K15436]
118620676  EEF1A1; elongation factor 1-alpha 1 [KO:K03231]
118620915  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
118621075  KPNA5; importin subunit alpha-6 [KO:K15042]
118621090  NUP43; nucleoporin Nup43 [KO:K14305]
118621476  XPO5; exportin-5 isoform X1 [KO:K14289]
118622519  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
118622556  IPO5; importin-5 isoform X1 [KO:K20222]
118622662  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
118623210  [KO:K14308]
118623452  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
118623467  XPO4; exportin-4 isoform X1 [KO:K25203]
118623620  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
118623631  RANGAP1; ran GTPase-activating protein 1 isoform X1 [KO:K14319]
118623757  PYM1; LOW QUALITY PROTEIN: partner of Y14 and mago [KO:K14294]
118623860  AAAS; aladin isoform X1 [KO:K14320]
118623937  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
118623954  IPO8; importin-8 isoform X1 [KO:K18755]
118624024  [KO:K12877]
118624030  NUP107; nuclear pore complex protein Nup107 isoform X1 [KO:K14301]
118624076  XPOT; exportin-T isoform X1 [KO:K14288]
118624445  [KO:K12160]
118624639  NUP37; nucleoporin Nup37 isoform X1 [KO:K14302]
118625498  NUP35; nucleoporin NUP35 isoform X1 [KO:K14313]
118625514  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
118625720  SUMO1; small ubiquitin-related modifier 1 [KO:K12160]
118626108  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
118626120  NDC1; nucleoporin NDC1 [KO:K14315]
118626153  IPO13; importin-13 isoform X1 [KO:K25202]
118626280  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
118626302  [KO:K12879]
118626533  MAGOH; protein mago nashi homolog [KO:K12877]
118626572  KPNA6; importin subunit alpha-7 isoform X1 [KO:K15042]
118626815  [KO:K03231]
118627029  RANBP2; E3 SUMO-protein ligase RanBP2 isoform X1 [KO:K12172] [EC:2.3.2.-]
118627606  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
118627641  IPO7; importin-7 isoform X1 [KO:K20223]
118627718  [KO:K12160]
118628235  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
118629082  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
118629275  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
118629466  NUP188; nucleoporin NUP188 homolog isoform X1 [KO:K14311]
118629494  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
118629589  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
118630503  XPO1; exportin-1 isoform X1 [KO:K14290]
118631032  [KO:K15043]
118633263  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
118633435  THOC7; THO complex subunit 7 homolog [KO:K13176]
118633893  KPNB1; importin subunit beta-1 isoform X1 [KO:K14293]
118634362  CASC3; protein CASC3 [KO:K14323]
118634395  ALYREF; THO complex subunit 4 [KO:K12881]
118634620  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
118634689  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
118634721  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
118634726  [KO:K15043]
118634751  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
118635417  [KO:K14328]
118635610  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
118636154  [KO:K14284]
118636161  [KO:K14284]
118636162  [KO:K14284]
118636163  [KO:K14284]
118636165  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
118636179  NUP62CL; LOW QUALITY PROTEIN: nucleoporin-62 C-terminal-like protein [KO:K14306]
118636180  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
118636207  [KO:K15043]
118636284  [KO:K14284]
118636290  TMEM33; transmembrane protein 33 isoform X1 [KO:K20724]
118636374  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
118636421  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
118636500  [KO:K12160]
118636605  IPO4; importin-4 [KO:K20221]
118636934  [KO:K03231]
118636939  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
118637141  POM121L2; POM121-like protein 2 [KO:K14316]
118637226  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
118637949  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
118637998  [KO:K12160]
118638999  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
118639211  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
118639459  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
118639461  [KO:K18655] [EC:5.6.2.7]
118639849  THOC5; THO complex subunit 5 homolog [KO:K13174]
118640207  RAN; GTP-binding nuclear protein Ran isoform X1 [KO:K07936]
118640505  IPO9; importin-9 [KO:K20224]
118640590  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
118640637  AHCTF1; protein ELYS isoform X1 [KO:K25129]
118640856  SNUPN; snurportin-1 isoform X1 [KO:K13151]
118641121  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
118641140  NUP50; nuclear pore complex protein Nup50 isoform X1 [KO:K14295]
118641392  TNPO1; transportin-1 isoform X1 [KO:K18752]
118641498  [KO:K12160]
118641737  THOC6; THO complex subunit 6 homolog [KO:K13175]
118641762  UBE2I; SUMO-conjugating enzyme UBC9 isoform X1 [KO:K10577]
118641819  IPO11; importin-11 isoform X1 [KO:K25201]
118641834  PHAX; phosphorylated adapter RNA export protein [KO:K14291]
118641857  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
118641930  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
118642204  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
118642841  XPO6; exportin-6 isoform X1 [KO:K25204]
118643425  PNN; pinin [KO:K13114]
118643632  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
mmf03015  mRNA surveillance pathway
KO pathway
ko03013   

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