| Localization of envoplakin and periplakin to the plasma membrane (PM) |
| Closslinking of envoplakin, periplakin and involucrin |
| Loricrin oligomerization with small proline-rich proteins and further stabilization |
| Ultra-long-chain omega-hydroxy fatty acyl-CoA synthesis |
| Sphinganine synthesis |
| Acylglucosylceramide synthesis |
| Transport of lipids into lamellar body (LB) |
| Peroxidation and deglycosylation of acylglucosylceramide |
| Processing of profilaggrin to filaggrin and binding to keratin filaments |
| Processing of filaggrin to amino acids |
| Histidine conversion to urocanic acid |
