KEGG   PATHWAY: nte03013
Entry
nte03013                    Pathway                                
Name
Nucleocytoplasmic transport - Neurospora tetrasperma
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
nte03013  Nucleocytoplasmic transport
nte03013

Other DBs
GO: 0050658
Organism
Neurospora tetrasperma [GN:nte]
Gene
NEUTE1DRAFT107425  NEUTE1DRAFT_107425; hypothetical protein [KO:K13025] [EC:5.6.2.7]
NEUTE1DRAFT116621  NEUTE1DRAFT_116621; hypothetical protein [KO:K20724]
NEUTE1DRAFT118176  NEUTE1DRAFT_118176; protein transport protein sec-13 [KO:K14004]
NEUTE1DRAFT118432  NEUTE1DRAFT_118432; ATP-dependent RNA helicase [KO:K12812] [EC:5.6.2.7]
NEUTE1DRAFT118521  NEUTE1DRAFT_118521; translation elongation factor eEF-1 alpha chain [KO:K03231]
NEUTE1DRAFT119293  NEUTE1DRAFT_119293; GTP-binding nuclear protein GSP1/Ran [KO:K07936]
NEUTE1DRAFT121236  NEUTE1DRAFT_121236; hypothetical protein [KO:K14299]
NEUTE1DRAFT122182  NEUTE1DRAFT_122182; Exportin-T [KO:K14288]
NEUTE1DRAFT123085  NEUTE1DRAFT_123085; hypothetical protein [KO:K12881]
NEUTE1DRAFT123959  NEUTE1DRAFT_123959; hypothetical protein [KO:K14289]
NEUTE1DRAFT124505  NEUTE1DRAFT_124505; hypothetical protein [KO:K20221]
NEUTE1DRAFT125078  NEUTE1DRAFT_125078; hypothetical protein [KO:K14325]
NEUTE1DRAFT126059  NEUTE1DRAFT_126059; hypothetical protein [KO:K14294]
NEUTE1DRAFT126254  NEUTE1DRAFT_126254; hypothetical protein [KO:K14301]
NEUTE1DRAFT126573  NEUTE1DRAFT_126573; hypothetical protein [KO:K14308]
NEUTE1DRAFT127323  NEUTE1DRAFT_127323; hypothetical protein [KO:K18423]
NEUTE1DRAFT127452  NEUTE1DRAFT_127452; hypothetical protein [KO:K18724]
NEUTE1DRAFT127621  NEUTE1DRAFT_127621; hypothetical protein [KO:K15042]
NEUTE1DRAFT129153  NEUTE1DRAFT_129153; hypothetical protein [KO:K14327]
NEUTE1DRAFT130437  NEUTE1DRAFT_130437; hypothetical protein [KO:K14309]
NEUTE1DRAFT130958  NEUTE1DRAFT_130958; hypothetical protein [KO:K25129]
NEUTE1DRAFT131732  NEUTE1DRAFT_131732; hypothetical protein [KO:K14297]
NEUTE1DRAFT133984  NEUTE1DRAFT_133984; hypothetical protein [KO:K14306]
NEUTE1DRAFT137741  NEUTE1DRAFT_137741; hypothetical protein [KO:K14310]
NEUTE1DRAFT144850  NEUTE1DRAFT_144850; hypothetical protein [KO:K14307]
NEUTE1DRAFT146404  NEUTE1DRAFT_146404; hypothetical protein [KO:K12883]
NEUTE1DRAFT148061  NEUTE1DRAFT_148061; hypothetical protein [KO:K18725]
NEUTE1DRAFT148083  NEUTE1DRAFT_148083; hypothetical protein [KO:K20222]
NEUTE1DRAFT150101  NEUTE1DRAFT_150101; hypothetical protein [KO:K12876]
NEUTE1DRAFT38114  NEUTE1DRAFT_38114; hypothetical protein [KO:K12877]
NEUTE1DRAFT55615  NEUTE1DRAFT_55615; hypothetical protein [KO:K25201]
NEUTE1DRAFT56450  NEUTE1DRAFT_56450; hypothetical protein [KO:K10577]
NEUTE1DRAFT56477  NEUTE1DRAFT_56477; Poly(A)+ RNA export protein [KO:K14298]
NEUTE1DRAFT56677  NEUTE1DRAFT_56677; hypothetical protein [KO:K12882]
NEUTE1DRAFT57767  NEUTE1DRAFT_57767; hypothetical protein [KO:K18723]
NEUTE1DRAFT57860  NEUTE1DRAFT_57860; hypothetical protein [KO:K18655] [EC:5.6.2.7]
NEUTE1DRAFT58426  NEUTE1DRAFT_58426; hypothetical protein [KO:K18752]
NEUTE1DRAFT61157  NEUTE1DRAFT_61157; hypothetical protein [KO:K07562]
NEUTE1DRAFT61458  NEUTE1DRAFT_61458; hypothetical protein [KO:K12879]
NEUTE1DRAFT65951  NEUTE1DRAFT_65951; hypothetical protein [KO:K14328]
NEUTE1DRAFT70739  NEUTE1DRAFT_70739; hypothetical protein [KO:K14293]
NEUTE1DRAFT70889  NEUTE1DRAFT_70889; hypothetical protein [KO:K20223]
NEUTE1DRAFT72406  NEUTE1DRAFT_72406; hypothetical protein [KO:K14319]
NEUTE1DRAFT72776  NEUTE1DRAFT_72776; hypothetical protein [KO:K14284]
NEUTE1DRAFT78469  NEUTE1DRAFT_78469; hypothetical protein [KO:K20224]
NEUTE1DRAFT79064  NEUTE1DRAFT_79064; hypothetical protein [KO:K15436]
NEUTE1DRAFT79323  NEUTE1DRAFT_79323; hypothetical protein [KO:K14312]
NEUTE1DRAFT80974  NEUTE1DRAFT_80974; hypothetical protein [KO:K12878]
NEUTE1DRAFT81823  NEUTE1DRAFT_81823; hypothetical protein [KO:K14324]
NEUTE1DRAFT81912  NEUTE1DRAFT_81912; hypothetical protein [KO:K14311]
NEUTE1DRAFT83987  NEUTE1DRAFT_83987; exportin-1 [KO:K14290]
NEUTE1DRAFT84149  NEUTE1DRAFT_84149; hypothetical protein [KO:K14315]
NEUTE1DRAFT87860  NEUTE1DRAFT_87860; hypothetical protein [KO:K14300]
NEUTE1DRAFT90482  NEUTE1DRAFT_90482; hypothetical protein [KO:K12881]
NEUTE1DRAFT90927  NEUTE1DRAFT_90927; hypothetical protein [KO:K13171]
NEUTE1DRAFT91019  NEUTE1DRAFT_91019; hypothetical protein [KO:K13174]
NEUTE1DRAFT91684  NEUTE1DRAFT_91684; hypothetical protein [KO:K12880]
NEUTE1DRAFT91712  NEUTE1DRAFT_91712; hypothetical protein [KO:K14303]
NEUTE1DRAFT98421  NEUTE1DRAFT_98421; hypothetical protein [KO:K14285]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
nte03015  mRNA surveillance pathway
KO pathway
ko03013   

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