KEGG   PATHWAY: aalb03013
Entry
aalb03013                   Pathway                                
Name
Nucleocytoplasmic transport - Aedes albopictus (Asian tiger mosquito)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
aalb03013  Nucleocytoplasmic transport
aalb03013

Other DBs
GO: 0050658
Organism
Aedes albopictus (Asian tiger mosquito) [GN:aalb]
Gene
109427764  aladin-like [KO:K14320]
109431338  aladin [KO:K14320]
109424528  LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96-like [KO:K14321]
109622242  nucleoporin GLE1 [KO:K18723]
109399955  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
109426914  mRNA export factor [KO:K14298]
109623328  mRNA export factor [KO:K14298]
115262691  mRNA export factor-like [KO:K14298]
109417255  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
109414310  nuclear pore complex protein Nup214-like [KO:K14317]
109421805  nuclear pore complex protein Nup88 [KO:K14318]
109622057  LOW QUALITY PROTEIN: E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
109415452  ran GTPase-activating protein [KO:K14319]
109422124  SUMO-conjugating enzyme UBC9-B [KO:K10577]
109424859  small ubiquitin-related modifier 3-like [KO:K12160]
109399475  nuclear pore complex protein Nup160 homolog [KO:K14303]
109401151  LOW QUALITY PROTEIN: nuclear pore complex protein Nup75 [KO:K14304]
109412161  LOW QUALITY PROTEIN: protein SEC13 homolog [KO:K14004]
115260868  LOW QUALITY PROTEIN: protein SEC13 homolog [KO:K14004]
109417121  nuclear pore complex protein Nup107 [KO:K14301]
115259523  nuclear pore complex protein Nup107-like [KO:K14301]
109415280  nuclear pore complex protein Nup133 [KO:K14300]
109623212  LOW QUALITY PROTEIN: nuclear pore complex protein Nup133 [KO:K14300]
109430543  nucleoporin seh1 [KO:K14299]
109428365  nucleoporin Nup43-like [KO:K14305]
109415224  nucleoporin Nup43-like [KO:K14305]
115257081  nucleoporin Nup43-like [KO:K14305]
109410611  nucleoporin Nup37-like [KO:K14302]
109410727  nucleoporin Nup37-like [KO:K14302]
115261490  protein ELYS homolog [KO:K25129]
109406316  LOW QUALITY PROTEIN: protein ELYS homolog [KO:K25129]
109401678  nuclear pore glycoprotein p62-like [KO:K14306]
109420336  LOW QUALITY PROTEIN: nuclear pore glycoprotein p62 [KO:K14306]
109398754  nuclear pore complex protein Nup58 [KO:K14307]
109418995  probable nucleoporin Nup54 isoform X1 [KO:K14308]
115255803  probable nucleoporin Nup54 [KO:K14308]
109401882  LOW QUALITY PROTEIN: nuclear pore complex protein Nup205 [KO:K14310]
109430832  nucleoporin NUP188 homolog [KO:K14311]
109420405  nuclear pore complex protein Nup154 [KO:K14312]
109404024  nuclear pore complex protein Nup93-1 [KO:K14309]
109427765  nucleoporin Nup35 [KO:K14313]
109431360  nucleoporin Nup35-like [KO:K14313]
115260710  LOW QUALITY PROTEIN: nucleoporin Nup35-like [KO:K14313]
109621885  nucleoporin Ndc1-like [KO:K14315]
109405424  nucleoporin Ndc1 [KO:K14315]
109414723  nuclear pore membrane glycoprotein 210-like [KO:K14314]
109398746  ice-structuring glycoprotein [KO:K14316]
109420079  Krueppel homolog 2-like [KO:K20724]
109416125  LOW QUALITY PROTEIN: nuclear pore complex protein Nup50 [KO:K14295]
109397699  LOW QUALITY PROTEIN: nuclear pore complex protein Nup153-like [KO:K14296]
109432974  nuclear pore complex protein Nup153-like isoform X1 [KO:K14296]
109418258  importin subunit alpha [KO:K15043]
109622833  importin subunit alpha-like [KO:K15043]
109428031  importin subunit alpha-3-like [KO:K23583]
109403649  importin subunit alpha-6 [KO:K15042]
109417679  importin subunit beta isoform X1 [KO:K14293]
109622165  importin subunit beta-like isoform X1 [KO:K14293]
109411127  transportin-1-like [KO:K18752]
115266579  transportin-1-like [KO:K18752]
109429094  transportin-3 isoform X1 [KO:K15436]
115261464  transportin-3-like isoform X1 [KO:K15436]
109398008  importin-4-like [KO:K20221]
109399473  importin-4-like [KO:K20221]
109422712  importin-5-like [KO:K20222]
109412317  importin-5 [KO:K20222]
109409715  importin-7-like [KO:K20223]
109417153  LOW QUALITY PROTEIN: importin-9-like [KO:K20224]
109406567  LOW QUALITY PROTEIN: importin-11 [KO:K25201]
109400989  importin-13 [KO:K25202]
109408279  LOW QUALITY PROTEIN: importin-13-like [KO:K25202]
109418903  deoxynucleotidyltransferase terminal-interacting protein 1 [KO:K13151]
109407764  snurportin-1 [KO:K13151]
109401363  exportin-1-like [KO:K14290]
109413104  LOW QUALITY PROTEIN: exportin-2 [KO:K18423]
109418539  LOW QUALITY PROTEIN: exportin-2 [KO:K18423]
115253990  exportin-2-like [KO:K18423]
109410579  LOW QUALITY PROTEIN: exportin-4 [KO:K25203]
109421150  LOW QUALITY PROTEIN: exportin-4-like [KO:K25203]
109410612  exportin-5 [KO:K14289]
115266727  exportin-6-A-like [KO:K25204]
109397861  exportin-6-A isoform X1 [KO:K25204]
109402681  exportin-6-A isoform X1 [KO:K25204]
109411857  exportin-7-like [KO:K18460]
115259769  exportin-7-like isoform X1 [KO:K18460]
115259782  exportin-7-like isoform X1 [KO:K18460]
109409292  GTP-binding nuclear protein Ran [KO:K07936]
109621276  GTP-binding nuclear protein Ran [KO:K07936]
109418321  elongation factor 1-alpha [KO:K03231]
109418072  elongation factor 1-alpha [KO:K03231]
109428099  elongation factor 1-alpha [KO:K03231]
115262136  elongation factor 1-alpha-like [KO:K03231]
109432557  phosphorylated adapter RNA export protein-like isoform X1 [KO:K14291]
109421451  phosphorylated adapter RNA export protein-like isoform X1 [KO:K14291]
109427984  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1-like [KO:K12882]
115268730  nuclear cap-binding protein subunit 1-like [KO:K12882]
115268732  LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1-like [KO:K12882]
109413671  nuclear cap-binding protein subunit 2 [KO:K12883]
109425019  60S ribosomal export protein NMD3 [KO:K07562]
109418604  60S ribosomal export protein NMD3 [KO:K07562]
109426594  RNA-binding protein 8A [KO:K12876]
109412057  protein mago nashi [KO:K12877]
109405422  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
109402421  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
115256192  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
115269180  eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
109423912  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
109404786  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
109430469  histone deacetylase complex subunit SAP18-like [KO:K14324]
115268465  histone deacetylase complex subunit SAP18-like [KO:K14324]
115268509  histone deacetylase complex subunit SAP18-like [KO:K14324]
109408287  RNA-binding protein with serine-rich domain 1-A [KO:K14325]
109405953  pinin [KO:K13114]
109417114  LOW QUALITY PROTEIN: pinin-like [KO:K13114]
109409539  THO complex subunit 4-like [KO:K12881]
109426403  THO complex subunit 4-like [KO:K12881]
109398022  THO complex subunit 4 [KO:K12881]
109405747  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
109406901  LOW QUALITY PROTEIN: regulator of nonsense transcripts 2 [KO:K14327]
115267134  LOW QUALITY PROTEIN: regulator of nonsense transcripts 2-like [KO:K14327]
109428707  regulator of nonsense transcripts 3B [KO:K14328]
109427121  nuclear RNA export factor 2 [KO:K14284]
109418413  nuclear RNA export factor 1-like [KO:K14284]
109400194  nuclear RNA export factor 2-like [KO:K14284]
109426144  LOW QUALITY PROTEIN: nuclear RNA export factor 1 [KO:K14284]
115254101  nuclear RNA export factor 1-like [KO:K14284]
109402269  NTF2-related export protein [KO:K14285]
109421659  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
109402590  partner of Y14 and mago [KO:K14294]
109425308  LOW QUALITY PROTEIN: THO complex subunit 1 [KO:K12878]
109415853  LOW QUALITY PROTEIN: THO complex subunit 2 [KO:K12879]
109413068  LOW QUALITY PROTEIN: THO complex subunit 5 homolog [KO:K13174]
109418496  LOW QUALITY PROTEIN: THO complex subunit 5 homolog [KO:K13174]
109419723  THO complex subunit 6-like [KO:K13175]
115269203  THO complex subunit 6-like [KO:K13175]
109427254  THO complex subunit 7 homolog [KO:K13176]
109411620  THO complex subunit 7 homolog [KO:K13176]
115261410  THO complex subunit 7 homolog [KO:K13176]
115254069  THO complex subunit 7 homolog [KO:K13176]
109415541  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
aalb03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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