KEGG PATHWAY: actw00630

KEGG

PATHWAY: actw00630

Entry

actw00630                   Pathway

Name

Glyoxylate and dicarboxylate metabolism - Actinomadura sp. WMMB 499

Class

Metabolism; Carbohydrate metabolism

Pathway map

Glyoxylate and dicarboxylate metabolism

Module

Glyoxylate cycle [PATH:actw00630]

Glycine cleavage system [PATH:actw00630]

Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:actw00630]

Other DBs

GO:	0046487 0043648

Organism

Actinomadura sp. WMMB 499 [GN:actw]

Gene

aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]

acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]

AMP-binding protein [KO:K01895] [EC:6.2.1.1]

malate synthase A [KO:K01638] [EC:2.3.3.9]

malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

citrate synthase [KO:K01647] [EC:2.3.3.1]

citrate synthase 2 [KO:K01647] [EC:2.3.3.1]

aconitate hydratase [KO:K01681] [EC:4.2.1.3]

acnA; aconitate hydratase AcnA [KO:K01681] [EC:4.2.1.3]

acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]

acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]

acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]

acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]

thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]

steroid 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]

acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]

acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]

steroid 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]

acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]

acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]

mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]

ATP-grasp domain-containing protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]

acyl-CoA carboxylase subunit beta [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]

acyl-CoA carboxylase subunit epsilon [KO:K27095]

methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]

scpA; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]

FAD-binding protein [KO:K00104] [EC:1.1.99.14]

FAD-binding protein [KO:K00104] [EC:1.1.99.14]

FAD-binding oxidoreductase [KO:K11472] [EC:1.1.99.14]

4Fe-4S dicluster domain-containing protein [KO:K11473] [EC:1.1.99.14]

catalase [KO:K03781] [EC:1.11.1.6]

catalase [KO:K03781] [EC:1.11.1.6]

catalase [KO:K03781] [EC:1.11.1.6]

HAD family hydrolase [KO:K01091] [EC:3.1.3.18]

HAD hydrolase-like protein [KO:K01091] [EC:3.1.3.18]

form I ribulose bisphosphate carboxylase large subunit [KO:K01601] [EC:4.1.1.39]

ribulose bisphosphate carboxylase small subunit [KO:K01602] [EC:4.1.1.39]

glutamine synthetase [KO:K01915] [EC:6.3.1.2]

glutamine synthetase [KO:K01915] [EC:6.3.1.2]

glutamine synthetase [KO:K01915] [EC:6.3.1.2]

glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]

serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]

gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]

gcvH; glycine cleavage system protein GcvH [KO:K02437]

TIM barrel protein [KO:K01816] [EC:5.3.1.22]

NAD-binding protein [KO:K00042] [EC:1.1.1.60]

glycerate kinase [KO:K00865] [EC:2.7.1.165]

glycerate kinase [KO:K00865] [EC:2.7.1.165]

tartrate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]

bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]

eda; bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]

dehydrogenase [KO:K00123] [EC:1.17.1.9]

molybdopterin-dependent oxidoreductase [KO:K00123] [EC:1.17.1.9]

4Fe-4S dicluster domain-containing protein [KO:K00124]

formate dehydrogenase [KO:K00127]

alpha/beta hydrolase [KO:K01432] [EC:3.5.1.9]

alpha/beta hydrolase [KO:K01432] [EC:3.5.1.9]

purU; formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]

Compound

Oxygen

CO2

Ammonia

Pyruvate

Acetyl-CoA

L-Glutamate

2-Oxoglutarate

Hydrogen peroxide

Acetate

Oxaloacetate

Glycine

Succinate

Glyoxylate

Formate

L-Glutamine

L-Serine

Succinyl-CoA

Propanoyl-CoA

Glycerone phosphate

Butanoyl-CoA

(S)-Malate

Citrate

Glycolate

Hydroxypyruvate

3-Phospho-D-glycerate

Oxalate

D-Glycerate

Glycolaldehyde

Isocitrate

Oxalyl-CoA

Acetoacetyl-CoA

cis-Aconitate

meso-Tartaric acid

2-Phospho-D-glycerate

(S)-Methylmalonyl-CoA

Formyl-CoA

Crotonoyl-CoA

Pentanoyl-CoA

(R,R)-Tartaric acid

Dihydroxyfumarate

2-Phosphoglycolate

4-Hydroxy-2-oxoglutarate

2-Hydroxy-3-oxopropanoate

D-Ribulose 1,5-bisphosphate

(R)-Methylmalonyl-CoA

Ethylene glycol

Mesaconate

3-Ethylmalate

3-Oxalomalate

3-Propylmalate

Formyl phosphate

2-Hydroxy-3-oxoadipate

2-Hydroxy-3-oxosuccinate

trans-2,3-Epoxysuccinate

(R)-3-Hydroxybutanoyl-CoA

L-threo-3-Methylaspartate

L-Malyl-CoA

L-erythro-3-Methylmalyl-CoA

2-Methylfumaryl-CoA

N-Formylderivatives

(2S)-Ethylmalonyl-CoA

(2S)-Methylsuccinyl-CoA

(2R)-Ethylmalonyl-CoA

D-Ribulose 1-phosphate

Reference

Authors

Njau RK, Herndon CA, Hawes JW.

Title

Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.

Journal

J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200

Reference

Authors

Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G

Title

Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.

Journal

J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07

Reference

Authors

Erb TJ, Retey J, Fuchs G, Alber BE

Title

Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.

Journal

J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200

Reference

Authors

Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM

Title

Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.

Journal

Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741

Reference

Authors

Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A

Title

Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.

Journal

Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910

Reference

Authors

Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA

Title

A methylaspartate cycle in haloarchaea.

Journal

Science 331:334-7 (2011)
DOI:10.1126/science.1196544

Reference

Authors

Serrano JA, Bonete MJ

Title

Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.

Journal

Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9

Related
pathway

Glycolysis / Gluconeogenesis

Citrate cycle (TCA cycle)

Pentose phosphate pathway

Ascorbate and aldarate metabolism

Fatty acid degradation

Purine metabolism

Alanine, aspartate and glutamate metabolism

Glycine, serine and threonine metabolism

Pyruvate metabolism

Carbon fixation by Calvin cycle

Vitamin B6 metabolism

Nitrogen metabolism

KO pathway

LinkDB

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