KEGG   PATHWAY: aew04145
Entry
aew04145                    Pathway                                
Name
Phagosome - Actinidia eriantha (wild kiwifruit)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
aew04145  Phagosome
aew04145

Other DBs
GO: 0045335
Organism
Actinidia eriantha (wild kiwifruit) [GN:aew]
Gene
130763060  syntaxin-81-like [KO:K08492]
130793124  syntaxin-81-like [KO:K08492]
130793224  syntaxin-81-like isoform X1 [KO:K08492]
130761255  25.3 kDa vesicle transport protein SEC22-1 [KO:K08517]
130761899  25.3 kDa vesicle transport protein SEC22-1 [KO:K08517]
130788540  25.3 kDa vesicle transport protein SEC22-1-like [KO:K08517]
130791561  25.3 kDa vesicle transport protein SEC22-1-like isoform X1 [KO:K08517]
130789332  ras-related protein RHN1-like isoform X1 [KO:K07888]
130756553  ras-related protein RHN1-like [KO:K07888]
130784659  ras-related protein RHN1-like isoform X1 [KO:K07888]
130760753  ras-related protein RABF1-like [KO:K07889]
130787275  ras-related protein RHN1-like isoform X1 [KO:K07889]
130778155  ras-related protein RHN1-like [KO:K07889]
130778197  ras-related protein RHN1-like [KO:K07889]
130784280  ras-related protein RHN1-like [KO:K07889]
130796162  ras-related protein RHN1-like isoform X1 [KO:K07889]
130758257  ras-related protein RHN1-like isoform X1 [KO:K07889]
130784802  ras-related protein RHN1 [KO:K07889]
130779462  phosphatidylinositol 3-kinase, root isoform [KO:K00914] [EC:2.7.1.137]
130775298  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
130788397  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
130750326  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
130793339  V-type proton ATPase subunit B 1 [KO:K02147]
130785176  V-type proton ATPase subunit B 2 [KO:K02147]
130761435  V-type proton ATPase subunit C-like [KO:K02148]
130750284  V-type proton ATPase subunit C-like [KO:K02148]
130767760  V-type proton ATPase subunit C-like [KO:K02148]
130750820  V-type proton ATPase subunit D-like [KO:K02149]
130767939  V-type proton ATPase subunit D-like [KO:K02149]
130770021  V-type proton ATPase subunit D-like [KO:K02149]
130765005  V-type proton ATPase subunit E-like [KO:K02150]
130792908  V-type proton ATPase subunit E-like [KO:K02150]
130795518  V-type proton ATPase subunit E-like [KO:K02150]
130751876  V-type proton ATPase subunit F-like [KO:K02151]
130791594  V-type proton ATPase subunit F [KO:K02151]
130770941  V-type proton ATPase subunit F-like [KO:K02151]
130763439  V-type proton ATPase subunit G 1-like [KO:K02152]
130771971  V-type proton ATPase subunit G 1-like [KO:K02152]
130772047  V-type proton ATPase subunit G 1-like [KO:K02152]
130751639  V-type proton ATPase subunit e1-like [KO:K02153]
130755759  V-type proton ATPase subunit e1-like [KO:K02153]
130771905  V-type proton ATPase subunit e1 [KO:K02153]
130785790  V-type proton ATPase subunit a3 [KO:K02154]
130761771  V-type proton ATPase subunit a1-like [KO:K02154]
130776086  V-type proton ATPase subunit a3-like [KO:K02154]
130790433  V-type proton ATPase subunit a1-like isoform X1 [KO:K02154]
130780469  V-type proton ATPase subunit a3-like [KO:K02154]
130760582  V-type proton ATPase subunit d2-like [KO:K02146]
130752310  V-type proton ATPase subunit d2 [KO:K02146]
130795368  V-type proton ATPase subunit H-like isoform X1 [KO:K02144]
130783563  V-type proton ATPase subunit H-like [KO:K02144]
130772831  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130785992  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130786024  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130776083  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130779912  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130780833  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130783872  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130784281  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130758881  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
130785546  V-type proton ATPase subunit c1-like [KO:K02155]
130788484  V-type proton ATPase subunit c''1-like [KO:K03661]
130765483  V-type proton ATPase subunit c''1 [KO:K03661]
130757173  V-type proton ATPase subunit c''1-like isoform X1 [KO:K03661]
130788075  ras-related protein Rab7-like [KO:K07897]
130788426  ras-related protein Rab7-like isoform X1 [KO:K07897]
130776622  ras-related protein Rab7-like [KO:K07897]
130750372  ras-related protein Rab7 [KO:K07897]
130777738  ras-related protein Rab7 [KO:K07897]
130779857  ras-related protein Rab7 [KO:K07897]
130780376  ras-related protein RABG3f-like [KO:K07897]
130754801  ras-related protein Rab7-like [KO:K07897]
130755942  ras-related protein Rab7-like [KO:K07897]
130759222  ras-related protein Rab7-like isoform X1 [KO:K07897]
130785658  ras-related protein Rab7 [KO:K07897]
130772943  tubulin alpha chain-like isoform X1 [KO:K07374]
130761357  tubulin alpha-5 chain [KO:K07374]
130787145  tubulin alpha chain-like [KO:K07374]
130774706  tubulin alpha chain-like [KO:K07374]
130788592  tubulin alpha chain-like [KO:K07374]
130777346  tubulin alpha chain [KO:K07374]
130753476  tubulin alpha-2 chain-like [KO:K07374]
130754200  tubulin alpha chain-like [KO:K07374]
130780921  tubulin alpha-3 chain-like [KO:K07374]
130768266  tubulin alpha chain-like [KO:K07374]
130769411  tubulin alpha chain-like [KO:K07374]
130773038  tubulin beta-5 chain [KO:K07375]
130786671  tubulin beta chain-like [KO:K07375]
130786711  tubulin beta chain-like [KO:K07375]
130762212  tubulin beta-2 chain-like [KO:K07375]
130788520  tubulin beta chain-like [KO:K07375]
130763560  tubulin beta-1 chain [KO:K07375]
130764073  tubulin beta-2 chain [KO:K07375]
130752109  tubulin beta-4 chain [KO:K07375]
130765766  tubulin beta-2 chain-like [KO:K07375]
130779581  tubulin beta chain [KO:K07375]
130791811  tubulin beta chain-like [KO:K07375]
130753547  tubulin beta chain-like [KO:K07375]
130793553  tubulin beta-2 chain-like [KO:K07375]
130755059  tubulin beta chain-like [KO:K07375]
130768134  tubulin beta-1 chain-like [KO:K07375]
130793843  tubulin beta chain-like [KO:K07375]
130794211  tubulin beta-2 chain-like [KO:K07375]
130759029  tubulin beta chain-like [KO:K07375]
130774010  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]
130787255  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like [KO:K00921] [EC:2.7.1.150]
130787913  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like isoform X1 [KO:K00921] [EC:2.7.1.150]
130776475  putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1D [KO:K00921] [EC:2.7.1.150]
130750586  LOW QUALITY PROTEIN: 1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like [KO:K00921] [EC:2.7.1.150]
130764987  LOW QUALITY PROTEIN: putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C [KO:K00921] [EC:2.7.1.150]
130796001  1-phosphatidylinositol-3-phosphate 5-kinase FAB1B-like [KO:K00921] [EC:2.7.1.150]
130762753  uncharacterized protein LOC130762753 [KO:K10956]
130778548  uncharacterized protein LOC130778548 [KO:K10956]
130752032  uncharacterized protein LOC130752032 [KO:K10956]
130753183  preprotein translocase subunit SCY1, chloroplastic [KO:K10956]
130755406  protein transport protein Sec61 subunit alpha-like [KO:K10956]
130755714  uncharacterized protein LOC130755714 [KO:K10956]
130783040  uncharacterized protein LOC130783040 [KO:K10956]
130773204  protein transport protein Sec61 subunit beta-like [KO:K09481]
130778053  protein transport protein Sec61 subunit beta-like [KO:K09481]
130767900  protein transport protein Sec61 subunit beta-like [KO:K09481]
130781382  protein transport protein Sec61 subunit beta-like [KO:K09481]
130782674  protein transport protein Sec61 subunit beta-like [KO:K09481]
130770822  protein transport protein Sec61 subunit beta-like [KO:K09481]
130760937  protein transport protein Sec61 subunit gamma-like [KO:K07342]
130773319  protein transport protein Sec61 subunit gamma-like [KO:K07342]
130775487  protein transport protein Sec61 subunit gamma-1-like [KO:K07342]
130776862  protein transport protein Sec61 subunit gamma-like isoform X1 [KO:K07342]
130754957  protein transport protein Sec61 subunit gamma-1 [KO:K07342]
130755267  protein transport protein Sec61 subunit gamma-like [KO:K07342]
130768754  protein transport protein Sec61 subunit gamma [KO:K07342]
130796294  protein transport protein Sec61 subunit gamma-like [KO:K07342]
130760537  calreticulin-3-like [KO:K08057]
130785924  calreticulin-like [KO:K08057]
130751033  calreticulin-3-like [KO:K08057]
130764515  calreticulin-3-like [KO:K08057]
130778575  calreticulin-like [KO:K08057]
130754326  calreticulin [KO:K08057]
130781817  calreticulin-like [KO:K08057]
130750339  calnexin homolog [KO:K08054]
130763118  calnexin homolog [KO:K08054]
130767865  calnexin homolog [KO:K08054]
130755948  calnexin homolog isoform X1 [KO:K08054]
130760951  LOW QUALITY PROTEIN: rac-like GTP-binding protein RAC2 [KO:K04392]
130773887  rac-like GTP-binding protein RAC13 [KO:K04392]
130776047  rac-like GTP-binding protein 5 [KO:K04392]
130750150  rac-like GTP-binding protein 3 [KO:K04392]
130790438  rac-like GTP-binding protein RAC2 [KO:K04392]
130778097  rac-like GTP-binding protein RHO1 [KO:K04392]
130780148  rac-like GTP-binding protein 5 [KO:K04392]
130753667  rac-like GTP-binding protein RAC1 [KO:K04392]
130767849  rac-like GTP-binding protein 3 [KO:K04392]
130782352  rac-like GTP-binding protein RAC2 [KO:K04392]
130794680  rac-like GTP-binding protein RAC2 [KO:K04392]
130795811  rac-like GTP-binding protein RAC13 [KO:K04392]
130757268  rac-like GTP-binding protein ARAC7 [KO:K04392]
130784190  rac-like GTP-binding protein RHO1 [KO:K04392]
130757817  LOW QUALITY PROTEIN: rac-like GTP-binding protein RAC1 [KO:K04392]
130757954  uncharacterized protein LOC130757954 [KO:K04392]
130758601  rac-like GTP-binding protein RHO1 [KO:K04392]
130785376  rac-like GTP-binding protein 5 [KO:K04392]
130785468  LOW QUALITY PROTEIN: rac-like GTP-binding protein ARAC7 [KO:K04392]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
aew04144  Endocytosis
KO pathway
ko04145   
LinkDB

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