KEGG   PATHWAY: amyc03410
Entry
amyc03410                   Pathway                                
Name
Base excision repair - Amycolatopsis sp. AA4
Description
Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
Class
Genetic Information Processing; Replication and repair
Pathway map
amyc03410  Base excision repair
amyc03410

Other DBs
GO: 0006284 0006285 0006286 0006287 0006288
Organism
Amycolatopsis sp. AA4 [GN:amyc]
Gene
CU254_36800  nth; endonuclease III [KO:K10773] [EC:3.2.2.- 4.2.99.18]
CU254_07140  uracil-DNA glycosylase [KO:K03648] [EC:3.2.2.27]
CU254_36180  A/G-specific adenine glycosylase [KO:K03575] [EC:3.2.2.31]
CU254_22440  DNA-3-methyladenine glycosylase [KO:K03652] [EC:3.2.2.21]
CU254_07345  bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
CU254_39960  Fpg/Nei family DNA glycosylase [KO:K10563] [EC:3.2.2.23 4.2.99.18]
CU254_24720  Fpg/Nei family DNA glycosylase [KO:K05522] [EC:3.2.2.- 4.2.99.18]
CU254_27515  Fpg/Nei family DNA glycosylase [KO:K05522] [EC:3.2.2.- 4.2.99.18]
CU254_30390  DNA-3-methyladenine glycosylase 2 family protein [KO:K13529] [EC:3.2.2.21]
CU254_32790  DNA-3-methyladenine glycosylase [KO:K13529] [EC:3.2.2.21]
CU254_03720  DNA-3-methyladenine glycosylase I [KO:K01246] [EC:3.2.2.20]
CU254_38495  G/U mismatch-specific DNA glycosylase [KO:K03649] [EC:3.2.2.28]
CU254_33520  uracil-DNA glycosylase [KO:K21929] [EC:3.2.2.27]
CU254_23595  uracil-DNA glycosylase [KO:K21929] [EC:3.2.2.27]
CU254_02740  xth; exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
CU254_11620  xth; exodeoxyribonuclease III [KO:K01142] [EC:3.1.11.2]
CU254_38965  deoxyribonuclease IV [KO:K01151] [EC:3.1.21.2]
CU254_22895  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
CU254_06785  NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
CU254_16275  NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Krwawicz J, Arczewska KD, Speina E, Maciejewska A, Grzesiuk E.
  Title
Bacterial DNA repair genes and their eukaryotic homologues: 1. Mutations in genes involved in base excision repair (BER) and DNA-end processors and their implication in mutagenesis and human disease.
  Journal
Acta Biochim Pol 54:413-34 (2007)
Reference
  Authors
Almeida KH, Sobol RW.
  Title
A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification.
  Journal
DNA Repair (Amst) 6:695-711 (2007)
DOI:10.1016/j.dnarep.2007.01.009
Reference
  Authors
Moen MN, Knaevelsrud I, Haugland GT, Grosvik K, Birkeland NK, Klungland A, Bjelland S
  Title
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
  Journal
J Bacteriol 193:4495-508 (2011)
DOI:10.1128/JB.00233-11
Reference
  Authors
Ikeda S, Seki S.
  Title
[Base excision repair: DNA glycosylase and AP endonuclease]
  Journal
Tanpakushitsu Kakusan Koso 46:916-23 (2001)
KO pathway
ko03410   
LinkDB

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