KEGG PATHWAY: arab04138

KEGG

PATHWAY: arab04138

Entry

arab04138                   Pathway

Name

Autophagy - yeast - Ascochyta rabiei

Description

Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.

Class

Cellular Processes; Transport and catabolism

Pathway map

Autophagy - yeast

Other DBs

GO:

Organism

Ascochyta rabiei [GN:arab]

Gene

RAS1 protein [KO:K07827]

RAS2 protein [KO:K07827]

uncharacterized protein [KO:K07827]

Non-specific serine/threonine protein kinase [KO:K04345] [EC:2.7.11.11]

cAMP-dependent protein kinase [KO:K04345] [EC:2.7.11.11]

Non-specific serine/threonine protein kinase [KO:K21157] [EC:2.7.11.1]

Non-specific serine/threonine protein kinase [KO:K12761] [EC:2.7.11.1]

Non-specific serine/threonine protein kinase [KO:K08269] [EC:2.7.11.1]

autophagy protein 13 [KO:K08331]

Autophagy-protein 17 [KO:K08329]

autophagy protein atg9 [KO:K17907]

autophagy-protein 2 [KO:K17906]

autophagy protein [KO:K17908]

type II membrane protein [KO:K21141]

oligomeric, coiled-coil, peripheral membrane protein [KO:K08330]

Arp2/3 complex subunit, actin nucleation center [KO:K17260]

Arp2/3 complex subunit, actin nucleation center [KO:K18584]

ARP2/3 actin-organizing complex subunit Sop2 [KO:K05757]

Arp complex subunit [KO:K05758]

subunit of the Arp2/3 complex [KO:K05756]

Arp complex subunit [KO:K05755]

uncharacterized protein [KO:K05754]

Non-specific serine/threonine protein kinase [KO:K19800] [EC:2.7.11.1]

Mitogen-activated protein kinase [KO:K04464] [EC:2.7.11.24]

Serine C-palmitoyltransferase [KO:K00654] [EC:2.3.1.50]

Serine C-palmitoyltransferase [KO:K00654] [EC:2.3.1.50]

Target of rapamycin complex 1 subunit kog1 [KO:K07204]

Non-specific serine/threonine protein kinase [KO:K07203] [EC:2.7.11.1]

TOR complex subunit lst8 [KO:K08266]

Type 2A phosphatase-associated protein 42 [KO:K17606]

Protein-serine/threonine phosphatase [KO:K04382] [EC:3.1.3.16]

Tap42 interacting protein [KO:K17607]

Non-specific serine/threonine protein kinase [KO:K12767] [EC:2.7.11.36]

Non-specific serine/threonine protein kinase [KO:K16196] [EC:2.7.11.1]

eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]

uncharacterized protein [KO:K06655] [EC:2.7.11.22]

PHO85 cyclin-5 [KO:K21197]

ubiquitin-like protein atg8 [KO:K08341]

Vacuolar protein sorting-associated protein atg6 [KO:K08334]

Non-specific serine/threonine protein kinase [KO:K08333] [EC:2.7.11.1]

Phosphatidylinositol 3-kinase [KO:K00914] [EC:2.7.1.137]

uncharacterized protein [KO:K00915] [EC:2.7.1.140 2.7.1.151]

Inositol-hexakisphosphate kinase [KO:K07756] [EC:2.7.4.21]

uncharacterized protein [KO:K18083] [EC:3.1.3.64 3.1.3.95]

Ubiquitin-like protein [KO:K08336]

dCMP deaminase [KO:K08337]

Autophagy protein 5 [KO:K08339]

E2-like enzyme [KO:K08343]

Cysteine protease atg4 [KO:K08342] [EC:3.4.22.-]

uncharacterized protein [KO:K08502]

t-SNARE VTI1 [KO:K08493]

palmitoyltransferase [KO:K08516]

Vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]

vesicular-fusion protein S17 [KO:K15296]

Rab GTPase ypt7 [KO:K07897]

Vacuolar fusion protein mon1 [KO:K20195]

Vacuolar protein sorting-associated protein 11 [KO:K20179]

Vacuolar protein sorting-associated protein 16 [KO:K20180]

tethering complex subunit [KO:K20181]

Vacuolar protein-sorting-associated protein 33 [KO:K20182]

uncharacterized protein [KO:K20177]

Vacuolar protein sorting-associated protein 8 [KO:K20178]

Vacuolar morphogenesis protein 6 [KO:K20183]

Vacuolar protein sorting-associated protein 41 [KO:K20184]

vacuolar protein sorting-associated protein 45 [KO:K12479]

Saccharopepsin [KO:K01381] [EC:3.4.23.25]

Oryzin [KO:K01336] [EC:3.4.21.48 3.4.21.-]

Cerevisin [KO:K01336] [EC:3.4.21.48 3.4.21.-]

Triacylglycerol lipase [KO:K17900] [EC:3.1.1.3]

Triacylglycerol lipase [KO:K17900] [EC:3.1.1.3]

Autophagy protein 22 [KO:K06902]

Autophagy protein 22 [KO:K06902]

uncharacterized protein [KO:K14209]

uncharacterized protein [KO:K14209]

Compound

Phosphatidylethanolamine

1-Phosphatidyl-D-myo-inositol

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Klionsky DJ, Emr SD.

Title

Autophagy as a regulated pathway of cellular degradation.

Journal

Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717

Reference

Authors

Thompson AR, Vierstra RD.

Title

Autophagic recycling: lessons from yeast help define the process in plants.

Journal

Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013

Reference

Authors

Lum JJ, DeBerardinis RJ, Thompson CB.

Title

Autophagy in metazoans: cell survival in the land of plenty.

Journal

Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660

Reference

Authors

Reggiori F, Klionsky DJ.

Title

Autophagosomes: biogenesis from scratch?

Journal

Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007

Reference

Authors

Levine B, Yuan J.

Title

Autophagy in cell death: an innocent convict?

Journal

J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390

Reference

Authors

Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y

Title

Dynamics and diversity in autophagy mechanisms: lessons from yeast.

Journal

Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708

Reference

Authors

He C, Klionsky DJ

Title

Regulation mechanisms and signaling pathways of autophagy.

Journal

Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910

Reference

Authors

Yang Z, Klionsky DJ

Title

An overview of the molecular mechanism of autophagy.

Journal

Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1

Reference

Authors

Chen Y, Klionsky DJ

Title

The regulation of autophagy - unanswered questions.

Journal

J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576

Reference

Authors

Mizushima N, Yoshimori T, Ohsumi Y

Title

The role of Atg proteins in autophagosome formation.

Journal

Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005

Reference

Authors

Reggiori F, Klionsky DJ

Title

Autophagic processes in yeast: mechanism, machinery and regulation.

Journal

Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013

Reference

Authors

Jin M, Klionsky DJ

Title

Regulation of autophagy: modulation of the size and number of autophagosomes.

Journal

FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015

Reference

Authors

Noda NN, Fujioka Y

Title

Atg1 family kinases in autophagy initiation.

Journal

Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z

KO pathway

LinkDB

DBGET integrated database retrieval system