KEGG   PATHWAY: bala00260
Entry
bala00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Baekduia alba
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bala00260  Glycine, serine and threonine metabolism
bala00260

Module
bala_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bala00260]
bala_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:bala00260]
bala_M00621  Glycine cleavage system [PATH:bala00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Baekduia alba [GN:bala]
Gene
DSM104299_01024  ask; Aspartokinase [KO:K00928] [EC:2.7.2.4]
DSM104299_01025  asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DSM104299_04490  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DSM104299_04485  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
DSM104299_02999  thrC_1; Threonine synthase [KO:K01733] [EC:4.2.3.1]
DSM104299_04489  thrC_2; Threonine synthase [KO:K01733] [EC:4.2.3.1]
DSM104299_03794  ltaE; Low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DSM104299_00180  glyA1_1; Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
DSM104299_01425  glyA1_2; Serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
DSM104299_03674  glyA2; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
DSM104299_00654  pucG; (S)-ureidoglycine--glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
DSM104299_05429  garK; Glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
DSM104299_01648  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
DSM104299_01714  apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15635] [EC:5.4.2.12]
DSM104299_01818  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DSM104299_02017  Hydroxypyruvate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DSM104299_02602  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DSM104299_02601  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
DSM104299_00161  kbl; 2-amino-3-ketobutyrate coenzyme A ligase [KO:K00639] [EC:2.3.1.29]
DSM104299_04783  bioF_2; 8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
DSM104299_02139  aofH_1; Putative flavin-containing monoamine oxidase AofH [KO:K00274] [EC:1.4.3.4]
DSM104299_04404  aofH_2; Putative flavin-containing monoamine oxidase AofH [KO:K00274] [EC:1.4.3.4]
DSM104299_02374  gcvPA; putative glycine dehydrogenase (decarboxylating) subunit 1 [KO:K00282] [EC:1.4.4.2]
DSM104299_02375  gcvPB; putative glycine dehydrogenase (decarboxylating) subunit 2 [KO:K00283] [EC:1.4.4.2]
DSM104299_02372  gcvT_2; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
DSM104299_00302  lpdC_1; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DSM104299_00417  lpd_1; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DSM104299_00910  ribonucleotide reductase large subunit [KO:K00382] [EC:1.8.1.4]
DSM104299_01782  lpdC_2; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DSM104299_02373  gcvH_2; Glycine cleavage system H protein [KO:K02437]
DSM104299_03641  soxA_2; Sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DSM104299_03670  soxA_3; Sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
DSM104299_03639  soxB_1; Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DSM104299_03673  soxB_2; Sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
DSM104299_03669  soxG; Sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
DSM104299_03672  soxD; Sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
DSM104299_05619  cbs; Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
DSM104299_04597  mdeA; L-methionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
DSM104299_00179  sdaB; L-serine dehydratase 2 [KO:K01752] [EC:4.3.1.17]
DSM104299_03668  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
DSM104299_00609  psdht; Phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
DSM104299_01851  tdcB; L-threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
DSM104299_03532  trpA; Tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
DSM104299_03534  trpB; Tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bala00010  Glycolysis / Gluconeogenesis
bala00020  Citrate cycle (TCA cycle)
bala00230  Purine metabolism
bala00250  Alanine, aspartate and glutamate metabolism
bala00270  Cysteine and methionine metabolism
bala00290  Valine, leucine and isoleucine biosynthesis
bala00300  Lysine biosynthesis
bala00330  Arginine and proline metabolism
bala00460  Cyanoamino acid metabolism
bala00470  D-Amino acid metabolism
bala00564  Glycerophospholipid metabolism
bala00600  Sphingolipid metabolism
bala00620  Pyruvate metabolism
bala00630  Glyoxylate and dicarboxylate metabolism
bala00640  Propanoate metabolism
bala00680  Methane metabolism
bala00860  Porphyrin metabolism
bala00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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