KEGG   PATHWAY: bct00630
Entry
bct00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Burkholderia cepacia GG4
Class
Metabolism; Carbohydrate metabolism
Pathway map
bct00630  Glyoxylate and dicarboxylate metabolism
bct00630

Module
bct_M00012  Glyoxylate cycle [PATH:bct00630]
bct_M00621  Glycine cleavage system [PATH:bct00630]
Other DBs
GO: 0046487 0043648
Organism
Burkholderia cepacia GG4 [GN:bct]
Gene
GEM_4139  isocitrate lyase [KO:K01637] [EC:4.1.3.1]
GEM_1393  isocitrate lyase [KO:K01637] [EC:4.1.3.1]
GEM_1224  acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
GEM_2137  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
GEM_3469  putative AMP-binding protein [KO:K01895] [EC:6.2.1.1]
GEM_5590  malate synthase G [KO:K01638] [EC:2.3.3.9]
GEM_1389  Malate synthase [KO:K01638] [EC:2.3.3.9]
GEM_4822  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
GEM_4968  Citrate synthase [KO:K01647] [EC:2.3.3.1]
GEM_0896  citrate synthase [KO:K01647] [EC:2.3.3.1]
GEM_4815  Citrate synthase I [KO:K01647] [EC:2.3.3.1]
GEM_4826  Aconitate hydratase @ 2-methylisocitrate dehydratase [KO:K01681] [EC:4.2.1.3]
GEM_4087  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
GEM_4093  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
GEM_0669  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
GEM_1523  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
GEM_1636  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
GEM_4665  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
GEM_0670  acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
GEM_1637  acetyacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
GEM_5594  Glycolate dehydrogenase, subunit GlcD [KO:K00104] [EC:1.1.99.14]
GEM_2792  FAD linked oxidase domain protein [KO:K00104] [EC:1.1.99.14]
GEM_2793  GlcE protein [KO:K11472] [EC:1.1.99.14]
GEM_5593  glycolate oxidase FAD binding subunit [KO:K11472] [EC:1.1.99.14]
GEM_2794  protein of unknown function DUF224 cysteine-rich region domain protein [KO:K11473] [EC:1.1.99.14]
GEM_5592  glycolate oxidase iron-sulfur subunit [KO:K11473] [EC:1.1.99.14]
GEM_0002  Catalase domain protein [KO:K03781] [EC:1.11.1.6]
GEM_4199  Catalase [KO:K03781] [EC:1.11.1.6]
GEM_0482  D-isomer specific 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
GEM_1682  Gluconate 2-dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
GEM_2415  2-hydroxyacid dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
GEM_1718  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
GEM_3600  hydrolase [KO:K01091] [EC:3.1.3.18]
GEM_2406  HAD-superfamily hydrolase, subfamily IA, variant 1 [KO:K01091] [EC:3.1.3.18]
GEM_2990  phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
GEM_3563  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
GEM_1258  L-glutamine synthetase [KO:K01915] [EC:6.3.1.2]
GEM_1279  glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
GEM_0450  putative glutamine synthetase [KO:K01915] [EC:6.3.1.2]
GEM_2727  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
GEM_3359  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
GEM_5265  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
GEM_0135  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
GEM_0137  glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
GEM_1923  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
GEM_1293  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
GEM_2214  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
GEM_0136  glycine cleavage system H protein [KO:K02437]
GEM_1547  glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
GEM_1546  hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
GEM_1545  2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
GEM_1500  glycerate kinase [KO:K00865] [EC:2.7.1.165]
GEM_5813  lactaldehyde dehydrogenase [KO:K07248] [EC:1.2.1.22 1.2.1.21]
GEM_4195  tartrate dehydratase subunit alpha [KO:K03779] [EC:4.2.1.32]
GEM_4194  L(+)-tartrate dehydratase subunit beta [KO:K03780] [EC:4.2.1.32]
GEM_5064  putative tartrate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
GEM_5555  tartrate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
GEM_2860  2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
GEM_2490  formate dehydrogenase subunit delta [KO:K00126] [EC:1.17.1.9]
GEM_4778  formate dehydrogenase, alpha subunit [KO:K00123] [EC:1.17.1.9]
GEM_4779  formate dehydrogenase [KO:K00123] [EC:1.17.1.9]
GEM_2489  formate dehydrogenase subunit alpha [KO:K00123] [EC:1.17.1.9]
GEM_2488  NADH dehydrogenase (quinone) [KO:K00124]
GEM_4777  formate dehydrogenase subunit beta [KO:K00124]
GEM_2487  NADH-ubiquinone oxidoreductase 24 kD subunit-like protein [KO:K00127]
GEM_4776  formate dehydrogenase subunit gamma [KO:K00127]
GEM_1713  esterase/lipase-like protein [KO:K01432] [EC:3.5.1.9]
GEM_0853  cyclase family protein [KO:K07130] [EC:3.5.1.9]
GEM_0660  formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
GEM_3370  formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
GEM_1256  N-formylglutamate amidohydrolase [KO:K01458] [EC:3.5.1.68]
GEM_4712  N-formylglutamate amidohydrolase [KO:K01458] [EC:3.5.1.68]
GEM_4702  N-formylglutamate deformylase [KO:K01458] [EC:3.5.1.68]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
bct00010  Glycolysis / Gluconeogenesis
bct00020  Citrate cycle (TCA cycle)
bct00030  Pentose phosphate pathway
bct00053  Ascorbate and aldarate metabolism
bct00071  Fatty acid degradation
bct00230  Purine metabolism
bct00250  Alanine, aspartate and glutamate metabolism
bct00260  Glycine, serine and threonine metabolism
bct00620  Pyruvate metabolism
bct00710  Carbon fixation by Calvin cycle
bct00750  Vitamin B6 metabolism
bct00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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