KEGG   PATHWAY: bdr04142
Entry
bdr04142                    Pathway                                
Name
Lysosome - Bactrocera dorsalis (oriental fruit fly)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
bdr04142  Lysosome
bdr04142

Other DBs
GO: 0005764
Organism
Bactrocera dorsalis (oriental fruit fly) [GN:bdr]
Gene
105231748  V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
105227547  V-type proton ATPase 116 kDa subunit a 1 isoform X2 [KO:K02154]
105231749  V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
105227818  V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
105230552  V-type proton ATPase 116 kDa subunit a 1 [KO:K02154]
105231750  V-type proton ATPase 116 kDa subunit a1-like [KO:K02154]
105224126  V-type proton ATPase subunit d 1 [KO:K02146]
105233539  V-type proton ATPase subunit H isoform X1 [KO:K02144]
105225418  V-type proton ATPase subunit S1 [KO:K03662]
105231147  V-type proton ATPase subunit S1 [KO:K03662]
105230160  V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
105230274  V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
105233165  dmX-like protein 2 [KO:K24155]
105223020  WD repeat-containing protein 7 [KO:K24738]
105226572  oxidation resistance protein 1 isoform X9 [KO:K25442]
105228237  cathepsin B [KO:K01363] [EC:3.4.22.1]
105225057  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
125775296  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105230796  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
115066347  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105228703  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105228704  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105229999  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
125779031  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
125779032  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
125779033  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
125779034  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
125779035  lysosomal aspartic protease-like [KO:K01379] [EC:3.4.23.5]
105230792  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105230797  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105230798  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105230799  lysosomal aspartic protease [KO:K01379] [EC:3.4.23.5]
105226576  putative cysteine proteinase CG12163 isoform X1 [KO:K01373] [EC:3.4.22.41]
105226824  procathepsin L [KO:K01371] [EC:3.4.22.38]
105232839  cathepsin L [KO:K01365] [EC:3.4.22.15]
105229843  procathepsin L [KO:K01365] [EC:3.4.22.15]
105223217  beta-galactosidase [KO:K12309] [EC:3.2.1.23]
105225659  LOW QUALITY PROTEIN: beta-galactosidase [KO:K12309] [EC:3.2.1.23]
125776279  lysosomal acid glucosylceramidase-like isoform X1 [KO:K01201] [EC:3.2.1.45]
105226747  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
105229345  alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
105225646  alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
105223262  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
105223785  beta-glucuronidase isoform X3 [KO:K01195] [EC:3.2.1.31]
105230050  putative alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
105224861  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
105224918  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
105227151  chitooligosaccharidolytic beta-N-acetylglucosaminidase [KO:K12373] [EC:3.2.1.52]
105229216  beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
105231812  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
105231934  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
105231810  beta-mannosidase [KO:K01192] [EC:3.2.1.25]
105232311  lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
105232312  lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
105226674  arylsulfatase J [KO:K01135] [EC:3.1.6.12]
105224017  arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
105230422  N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
105233690  iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
105222132  N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
105224212  lipase 3 [KO:K01052] [EC:3.1.1.13]
105229906  lipase 3 [KO:K01052] [EC:3.1.1.13]
105224715  lipase 3 [KO:K01052] [EC:3.1.1.13]
105229308  phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
105223550  deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
105231729  lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
125775277  prostatic acid phosphatase [KO:K14410] [EC:3.1.3.2]
125779984  lysosomal acid phosphatase-like [KO:K14410] [EC:3.1.3.2]
105226393  lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
105224709  sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
105228369  putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase GA14866 [KO:K01444] [EC:3.5.1.26]
105233909  uncharacterized protein LOC105233909 [KO:K12382]
105224915  palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
105223306  lysosome-associated membrane glycoprotein 1 [KO:K06528]
105224057  CD63 antigen [KO:K06497]
105227768  23 kDa integral membrane protein [KO:K06497]
105227769  23 kDa integral membrane protein [KO:K06497]
105227770  23 kDa integral membrane protein [KO:K06497]
125777678  CD63 antigen-like [KO:K06497]
105227766  23 kDa integral membrane protein [KO:K06497]
105222034  CD63 antigen [KO:K06497]
105223015  NPC intracellular cholesterol transporter 1 homolog 1b [KO:K12385]
125775280  NPC intracellular cholesterol transporter 1-like [KO:K12385]
105233589  NPC intracellular cholesterol transporter 1 [KO:K12385]
105226761  MD-2-related lipid-recognition protein [KO:K13443]
105233217  ecdysteroid-regulated 16 kDa protein [KO:K13443]
115066548  NPC intracellular cholesterol transporter 2 isoform X1 [KO:K13443]
105231850  NPC intracellular cholesterol transporter 2 [KO:K13443]
105231849  NPC intracellular cholesterol transporter 2 [KO:K13443]
125776592  NPC intracellular cholesterol transporter 2-like [KO:K13443]
105228597  NPC intracellular cholesterol transporter 2 homolog a [KO:K13443]
105223150  cystinosin homolog isoform X3 [KO:K12386]
105223033  sialin [KO:K12301]
105226686  putative inorganic phosphate cotransporter isoform X1 [KO:K12301]
105226543  protein Malvolio isoform X2 [KO:K21398]
105233068  lysosomal-associated transmembrane protein 4A [KO:K12387]
105224864  integumentary mucin C.1 [KO:K06546]
105224023  battenin [KO:K12389]
105224021  battenin-like [KO:K12389]
105227880  major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
125775337  major facilitator superfamily domain-containing protein 8-like [KO:K12307]
105228814  heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
105227012  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
105225419  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
125776600  cation-independent mannose-6-phosphate receptor-like [KO:K06564]
105222101  cation-independent mannose-6-phosphate receptor [KO:K06564]
105232075  clathrin heavy chain [KO:K04646]
105225714  AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
105231994  AP-1 complex subunit beta-1 [KO:K12392]
105229560  AP-1 complex subunit mu-1 [KO:K12393]
105232614  AP-1 complex subunit sigma-2 isoform X2 [KO:K12394]
105225508  AP-3 complex subunit delta isoform X1 [KO:K12396]
105223557  AP-3 complex subunit beta-2 [KO:K12397]
105234262  AP-3 complex subunit mu-2 [KO:K12398]
105223218  AP-3 complex subunit sigma-1 [KO:K12399]
105225529  ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
105224582  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
105233669  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
105233670  lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
125777073  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
105233675  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
105234063  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1 [KO:K19363]
105233671  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
125777636  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
bdr00511  Other glycan degradation
bdr00531  Glycosaminoglycan degradation
bdr04130  SNARE interactions in vesicular transport
bdr04140  Autophagy - animal
bdr04144  Endocytosis
KO pathway
ko04142   
LinkDB

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