Entry |
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Symbol |
SMPD1, ASM
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Name |
sphingomyelin phosphodiesterase [EC: 3.1.4.12]
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Pathway |
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Reaction |
R02541 | sphingomyelin cholinephosphohydrolase |
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Disease |
H00137 | Niemann-Pick disease type A/B |
H00424 | Defects in the degradation of sphingomyelin |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09103 Lipid metabolism
00600 Sphingolipid metabolism
K12350 SMPD1, ASM; sphingomyelin phosphodiesterase
09130 Environmental Information Processing
09132 Signal transduction
04071 Sphingolipid signaling pathway
K12350 SMPD1, ASM; sphingomyelin phosphodiesterase
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
K12350 SMPD1, ASM; sphingomyelin phosphodiesterase
09143 Cell growth and death
04217 Necroptosis
K12350 SMPD1, ASM; sphingomyelin phosphodiesterase
Enzymes [BR:ko01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.12 sphingomyelin phosphodiesterase
K12350 SMPD1, ASM; sphingomyelin phosphodiesterase
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Other DBs |
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Genes |
» show all
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Reference |
|
Authors |
Lin X, Hengartner MO, Kolesnick R |
Title |
Caenorhabditis elegans contains two distinct acid sphingomyelinases. |
Journal |
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Sequence |
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Reference |
|
Authors |
Schuchman EH, Suchi M, Takahashi T, Sandhoff K, Desnick RJ |
Title |
Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. |
Journal |
J Biol Chem 266:8531-9 (1991) |
Sequence |
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LinkDB |
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