KEGG   PATHWAY: bpl02024
Entry
bpl02024                    Pathway                                
Name
Quorum sensing - Burkholderia pseudomallei 1106a
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
bpl02024  Quorum sensing
bpl02024

Other DBs
GO: 0009372
Organism
Burkholderia pseudomallei 1106a [GN:bpl]
Gene
BURPS1106A_2222  hfq; RNA chaperone Hfq [KO:K03666]
BURPS1106A_1799  hfq; RNA chaperone Hfq [KO:K03666]
BURPS1106A_3583  trpE; anthranilate synthase component I [KO:K01657] [EC:4.1.3.27]
BURPS1106A_3584  trpG; anthranilate synthase component II [KO:K01658] [EC:4.1.3.27]
BURPS1106A_A0657  metallo-beta-lactamase family protein [KO:K20257] [EC:3.1.2.32]
BURPS1106A_A1221  bpsI; autoinducer synthase BpsI [KO:K13061] [EC:2.3.1.184]
BURPS1106A_A1577  autoinducer synthetase [KO:K13061] [EC:2.3.1.184]
BURPS1106A_A0723  rhlA; rhamnosyltransferase I, subunit A [KO:K18100] [EC:2.4.1.-]
BURPS1106A_A1834  rhlA; rhamnosyltransferase I, subunit A [KO:K18100] [EC:2.4.1.-]
BURPS1106A_A0725  rhlB; rhamnosyltransferase I, subunit B [KO:K18101] [EC:2.4.1.-]
BURPS1106A_A1832  rhlB; rhamnosyltransferase I, subunit B [KO:K18101] [EC:2.4.1.-]
BURPS1106A_A0728  rhamnosyltransferase [KO:K12990] [EC:2.4.1.-]
BURPS1106A_A1829  rhamnosyltransferase [KO:K12990] [EC:2.4.1.-]
BURPS1106A_A0779  putative peptidase [KO:K08642] [EC:3.4.24.-]
BURPS1106A_A1752  aroG; phospho-2-dehydro-3-deoxyheptonate aldolase [KO:K01626] [EC:2.5.1.54]
BURPS1106A_3325  aroG; phospho-2-dehydro-3-deoxyheptonate aldolase [KO:K01626] [EC:2.5.1.54]
BURPS1106A_3941  flhD; flagellar transcriptional activator FlhD [KO:K02403]
BURPS1106A_3246  FlhD family protein [KO:K02403]
BURPS1106A_3940  flhC; flagellar transcriptional activator FlhC [KO:K02402]
BURPS1106A_1254  kdpE; KDP operon transcriptional regulatory protein KdpE [KO:K07667]
BURPS1106A_A2362  putative polyamine ABC transporter, periplasmic polyamine-binding protein [KO:K02055]
BURPS1106A_A0354  putative ABC transporter, periplasmic substrate-binding protein [KO:K02055]
BURPS1106A_1419  ABC transporter, periplasmic substrate-binding protein [KO:K02055]
BURPS1106A_0140  bacterial extracellular solute-binding protein [KO:K02055]
BURPS1106A_A0352  ABC transporter, permease protein [KO:K02053]
BURPS1106A_A2359  putative polyamine ABC transporter, permease protein [KO:K02053]
BURPS1106A_1418  ABC transporter, permease protein [KO:K02053]
BURPS1106A_1415  ABC transporter, permease protein [KO:K02053]
BURPS1106A_A0355  ABC transporter, permease protein [KO:K02053]
BURPS1106A_A2360  putative polyamine ABC transporter, permease protein [KO:K02054]
BURPS1106A_A2363  polyamine ABC transporter, ATP-binding protein [KO:K02052]
BURPS1106A_1413  ABC transporter, ATP-binding protein [KO:K02052]
BURPS1106A_A0353  ABC transporter, ATP-binding protein [KO:K02052]
BURPS1106A_2807  putative periplasmic substrate-binding protein [KO:K01999]
BURPS1106A_3912  putative amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BURPS1106A_A1102  putative amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BURPS1106A_1291  putative amino acid-binding protein [KO:K01999]
BURPS1106A_0056  putative ABC transporter, substrate-binding protein [KO:K01999]
BURPS1106A_4031  putative periplasmic substrate-binding protein [KO:K01999]
BURPS1106A_4065  putative amino acid uptake ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BURPS1106A_4060  putative amino acid uptake ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
BURPS1106A_A0772  high-affinity branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid-binding protein [KO:K01999]
BURPS1106A_1977  putative transporter, periplasmic substrate-binding protein [KO:K01999]
BURPS1106A_0989  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, permease protein [KO:K01997]
BURPS1106A_4059  putative amino acid uptake ABC transporter, permease protein [KO:K01997]
BURPS1106A_0055  ABC transporter, permease protein [KO:K01997]
BURPS1106A_4063  putative amino acid uptake ABC transporter, permease protein [KO:K01997]
BURPS1106A_1671  ABC transporter, permease protein [KO:K01997]
BURPS1106A_A0773  high-affinity branched-chain amino acid ABC transporter, permease protein [KO:K01997]
BURPS1106A_0990  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, permease protein [KO:K01998]
BURPS1106A_1672  ABC transporter, permease/ATP-binding protein [KO:K01995 K01998]
BURPS1106A_0054  ABC transporter, permease protein [KO:K01998]
BURPS1106A_4062  putative amino acid uptake ABC transporter, permease protein [KO:K01998]
BURPS1106A_4058  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding/permease protein [KO:K01995 K01998]
BURPS1106A_A0774  high-affinity branched-chain amino acid ABC transporter, permease protein [KO:K01998]
BURPS1106A_0053  ABC transporter, ATP-binding protein [KO:K01995]
BURPS1106A_4067  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01995]
BURPS1106A_0991  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01995]
BURPS1106A_A0775  high-affinity branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
BURPS1106A_0992  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01996]
BURPS1106A_4066  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01996]
BURPS1106A_1673  ABC transporter, ATP-binding protein [KO:K01996]
BURPS1106A_A0776  high-affinity branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01996]
BURPS1106A_4057  ABC transporter, hydrophobic amino acid uptake transporter (HAAT) family, ATP-binding protein [KO:K01996]
BURPS1106A_0051  ABC transporter, ATP-binding protein [KO:K01996]
BURPS1106A_A1223  bpsR; autoinducer-binding transcriptional regulator BpsR [KO:K19666]
BURPS1106A_A2129  bpmI; autoinducer synthetase BpmI [KO:K20250] [EC:2.3.1.184]
BURPS1106A_A2128  bmpR; autoinducer-binding transcriptional regulator BmpR [KO:K19731]
BURPS1106A_A2104  thermolysin metallopeptidase [KO:K20273]
BURPS1106A_A0758  fungalysin/thermolysin propeptide domain protein [KO:K20274]
BURPS1106A_0386  conserved hypothetical protein [KO:K20275]
BURPS1106A_1803  fadD; long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
BURPS1106A_3563  AMP-binding domain protein [KO:K01897] [EC:6.2.1.3]
BURPS1106A_0916  AMP-binding domain protein [KO:K01897] [EC:6.2.1.3]
BURPS1106A_A2780  AMP-binding domain protein [KO:K01897] [EC:6.2.1.3]
BURPS1106A_0938  cyclic nucleotide-binding protein [KO:K10914]
BURPS1106A_0871  transcriptional regulator, Fur family [KO:K09823]
BURPS1106A_1370  transcriptional regulator, IclR family [KO:K20329]
BURPS1106A_A1220  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
BURPS1106A_A1501  GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
BURPS1106A_A1502  WD domain protein [KO:K20332]
BURPS1106A_A1504  conserved hypothetical protein [KO:K20333]
BURPS1106A_A1505  ribD; riboflavin biosynthesis protein RibD [KO:K11752] [EC:3.5.4.26 1.1.1.193]
BURPS1106A_3065  ribD; riboflavin biosynthesis protein RibD [KO:K11752] [EC:3.5.4.26 1.1.1.193]
BURPS1106A_A1496  efflux transporter, RND family, MFP subunit [KO:K18306]
BURPS1106A_A1497  RND transporter, HAE1/HME family [KO:K18307]
BURPS1106A_1905  oprA; outer membrane efflux protein OprA [KO:K18139]
BURPS1106A_0861  oprM; outer membrane efflux protein OprM [KO:K18139]
BURPS1106A_A1499  oprM; outer membrane efflux protein OprM [KO:K18139]
BURPS1106A_A2631  efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family [KO:K18139]
BURPS1106A_A2903  oppA; oligopeptide ABC transporter, periplasmic oligopeptide-binding protein [KO:K15580]
BURPS1106A_A2902  oppB; oligopeptide ABC transporter, permease protein OppB [KO:K15581]
BURPS1106A_A2901  oppC; oligopeptide ABC transporter, permease protein OppC [KO:K15582]
BURPS1106A_A2900  oppD; oligopeptide ABC transporter, ATP-binding protein OppD [KO:K15583]
BURPS1106A_A2899  oppF; oligopeptide ABC transporter, ATP-binding protein OppF [KO:K10823]
BURPS1106A_A1329  bacterial extracellular solute-binding protein, family 5 [KO:K02035]
BURPS1106A_A1311  ABC transporter, periplasmic substrate-binding protein [KO:K02035]
BURPS1106A_A1310  ABC transporter, permease protein [KO:K02033]
BURPS1106A_A1309  ABC transporter, permease protein [KO:K02034]
BURPS1106A_A1308  ABC transporter, ATP-binding protein [KO:K02031]
BURPS1106A_A1306  ABC transporter, ATP-binding protein [KO:K02032]
BURPS1106A_0107  oxaA; membrane protein insertase, YidC/Oxa1 family [KO:K03217]
BURPS1106A_A2709  mprA; serine metalloprotease MprA [KO:K14645] [EC:3.4.21.-]
BURPS1106A_A1343  putative serine metalloprotease [KO:K14645] [EC:3.4.21.-]
BURPS1106A_3822  secE; preprotein translocase, SecE subunit [KO:K03073]
BURPS1106A_1297  secG; preprotein translocase, SecG subunit [KO:K03075]
BURPS1106A_3784  secY; preprotein translocase, SecY subunit [KO:K03076]
BURPS1106A_3363  yajC; preprotein translocase, YajC subunit [KO:K03210]
BURPS1106A_3540  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
BURPS1106A_0576  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
BURPS1106A_0500  secB; protein-export chaperone SecB [KO:K03071]
BURPS1106A_3517  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
BURPS1106A_1812  phosphoesterase family protein [KO:K01114] [EC:3.1.4.3]
BURPS1106A_A1778  phosphoesterase family protein [KO:K01114] [EC:3.1.4.3]
BURPS1106A_0372  plcN_2; non-hemolytic phospholipase C [KO:K01114] [EC:3.1.4.3]
BURPS1106A_2804  plcN_1; non-hemolytic phospholipase C [KO:K01114] [EC:3.1.4.3]
BURPS1106A_A0091  plcN; non-hemolytic phospholipase C [KO:K01114] [EC:3.1.4.3]
BURPS1106A_A1043  phosphoesterase family protein [KO:K01114] [EC:3.1.4.3]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
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FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
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Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
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Int J Mol Sci 14:16386-401 (2013)
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PMID:24348467
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Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
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Front Microbiol 4:356 (2013)
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Reference
PMID:24065108
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Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
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Int J Mol Sci 14:19309-40 (2013)
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PMID:20738404
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FEMS Microbiol Rev 35:247-74 (2011)
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PMID:25866808
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Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
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The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
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Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
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J Bacteriol 183:5529-34 (2001)
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PMID:11497469
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Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
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Mol Plant Microbe Interact 14:969-79 (2001)
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Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
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The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
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Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
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Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
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Nature 492:113-7 (2012)
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Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
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Proc Natl Acad Sci U S A 109:12141-6 (2012)
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Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
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Quorum-sensing in Rhizobium.
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  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
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J Bacteriol 181:3816-23 (1999)
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Reference
PMID:24550924
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Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
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Front Plant Sci 5:14 (2014)
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Reference
PMID:23710277
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In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
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Commun Integr Biol 6:e23692 (2013)
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Quorum sensing in Erwinia species.
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Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
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PMID:19843225
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Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
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Mol Microbiol 74:903-13 (2009)
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Reference
PMID:7665477
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  Title
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
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J Bacteriol 177:5000-8 (1995)
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Reference
PMID:19761612
  Authors
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  Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
  Journal
BMC Genomics 10:441 (2009)
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Reference
PMID:16041013
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Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
  Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
  Journal
Infect Immun 73:4982-92 (2005)
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Reference
PMID:22949660
  Authors
Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang LH
  Title
Cis-2-dodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.
  Journal
Proc Natl Acad Sci U S A 109:15479-84 (2012)
DOI:10.1073/pnas.1205037109
Reference
PMID:23799665
  Authors
Suppiger A, Schmid N, Aguilar C, Pessi G, Eberl L
  Title
Two quorum sensing systems control biofilm formation and virulence in members of the Burkholderia cepacia complex.
  Journal
Virulence 4:400-9 (2013)
DOI:10.4161/viru.25338
Reference
PMID:21166386
  Authors
Deng Y, Wu J, Tao F, Zhang LH
  Title
Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria.
  Journal
Chem Rev 111:160-73 (2011)
DOI:10.1021/cr100354f
Reference
PMID:21227698
  Authors
Ryan RP, Dow JM
  Title
Communication with a growing family: diffusible signal factor (DSF) signaling in bacteria.
  Journal
Trends Microbiol 19:145-52 (2011)
DOI:10.1016/j.tim.2010.12.003
Reference
PMID:15522077
  Authors
Kim J, Kim JG, Kang Y, Jang JY, Jog GJ, Lim JY, Kim S, Suga H, Nagamatsu T, Hwang I
  Title
Quorum sensing and the LysR-type transcriptional activator ToxR regulate toxoflavin biosynthesis and transport in Burkholderia glumae.
  Journal
Mol Microbiol 54:921-34 (2004)
DOI:10.1111/j.1365-2958.2004.04338.x
Reference
PMID:17376080
  Authors
Kim J, Kang Y, Choi O, Jeong Y, Jeong JE, Lim JY, Kim M, Moon JS, Suga H, Hwang I
  Title
Regulation of polar flagellum genes is mediated by quorum sensing and FlhDC in Burkholderia glumae.
  Journal
Mol Microbiol 64:165-79 (2007)
DOI:10.1111/j.1365-2958.2007.05646.x
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Related
pathway
bpl00405  Phenazine biosynthesis
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KO pathway
ko02024   
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