KEGG   PATHWAY: brk00061
Entry
brk00061                    Pathway                                
Name
Fatty acid biosynthesis - Bradyrhizobium sp. SK17
Class
Metabolism; Lipid metabolism
Pathway map
brk00061  Fatty acid biosynthesis
brk00061

Module
brk_M00082  Fatty acid biosynthesis, initiation [PATH:brk00061]
brk_M00083  Fatty acid biosynthesis, elongation [PATH:brk00061]
brk_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:brk00061]
Other DBs
GO: 0006633
Organism
Bradyrhizobium sp. SK17 [GN:brk]
Gene
CWS35_04185  acetyl-CoA carboxylase carboxyltransferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
CWS35_23055  accB; acetyl-CoA carboxylase biotin carboxyl carrier protein [KO:K02160]
CWS35_23050  accC; acetyl-CoA carboxylase biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
CWS35_05595  acetyl-CoA carboxylase carboxyltransferase subunit beta [KO:K01963] [EC:6.4.1.2 2.1.3.15]
CWS35_22235  fabD; [acyl-carrier-protein] S-malonyltransferase [KO:K00645] [EC:2.3.1.39]
CWS35_26575  3-oxoacyl-ACP synthase [KO:K00648] [EC:2.3.1.180]
CWS35_05450  beta-ketoacyl-[acyl-carrier-protein] synthase I [KO:K00647] [EC:2.3.1.41]
CWS35_22250  fabF; beta-ketoacyl-[acyl-carrier-protein] synthase II [KO:K09458] [EC:2.3.1.179]
CWS35_36220  fabF; beta-ketoacyl-[acyl-carrier-protein] synthase II [KO:K09458] [EC:2.3.1.179]
CWS35_28175  beta-ketoacyl-ACP synthase II [KO:K09458] [EC:2.3.1.179]
CWS35_28180  beta-ketoacyl-ACP synthase II [KO:K09458] [EC:2.3.1.179]
CWS35_22240  fabG; 3-oxoacyl-[acyl-carrier-protein] reductase [KO:K00059] [EC:1.1.1.100]
CWS35_28280  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
CWS35_28320  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
CWS35_11755  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
CWS35_01855  3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
CWS35_01860  NAD(P)-dependent oxidoreductase [KO:K00059] [EC:1.1.1.100]
CWS35_16600  3-oxoacyl-ACP reductase FabG [KO:K00059] [EC:1.1.1.100]
CWS35_13800  NAD(P)-dependent oxidoreductase [KO:K00059] [EC:1.1.1.100]
CWS35_11210  3-ketoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
CWS35_15840  hypothetical protein [KO:K00059] [EC:1.1.1.100]
CWS35_15845  hypothetical protein [KO:K00059] [EC:1.1.1.100]
CWS35_24865  hypothetical protein [KO:K00059] [EC:1.1.1.100]
CWS35_03870  NAD(P)-dependent oxidoreductase [KO:K00059] [EC:1.1.1.100]
CWS35_16735  short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
CWS35_29865  beta-hydroxydecanoyl-ACP dehydratase [KO:K01716] [EC:4.2.1.59 5.3.3.14]
CWS35_05455  3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA [KO:K01716] [EC:4.2.1.59 5.3.3.14]
CWS35_25850  fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
CWS35_28170  beta-hydroxyacyl-ACP dehydratase [KO:K02372] [EC:4.2.1.59]
CWS35_05445  enoyl-[acyl-carrier-protein] reductase FabV [KO:K00209] [EC:1.3.1.9 1.3.1.44]
CWS35_16055  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_08920  acyl-CoA synthetase [KO:K01897] [EC:6.2.1.3]
CWS35_01520  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_14925  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_14965  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_02875  pimA; dicarboxylate--CoA ligase PimA [KO:K01897] [EC:6.2.1.3]
CWS35_10780  long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_17995  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_03380  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_13805  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_31715  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_08875  AMP-dependent synthetase [KO:K01897] [EC:6.2.1.3]
CWS35_35930  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
CWS35_28305  fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
brk00020  Citrate cycle (TCA cycle)
brk00071  Fatty acid degradation
brk00410  beta-Alanine metabolism
brk00561  Glycerolipid metabolism
brk00564  Glycerophospholipid metabolism
brk00620  Pyruvate metabolism
brk00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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