KEGG   PATHWAY: burk03070
Entry
burk03070                   Pathway                                
Name
Bacterial secretion system - Burkholderia sp. JP2-270
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
burk03070  Bacterial secretion system
burk03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Burkholderia sp. JP2-270 [GN:burk]
Gene
DM992_13970  porin [KO:K12340]
DM992_27405  TolC family protein [KO:K12340]
DM992_30940  TolC family protein [KO:K12340]
DM992_27400  HlyD family type I secretion periplasmic adaptor subunit [KO:K11003]
DM992_27395  type I secretion system permease/ATPase [KO:K11004]
DM992_21780  EscC/YscC/HrcC family type III secretion system outer membrane ring protein [KO:K03219]
DM992_21760  EscJ/YscJ/HrcJ family type III secretion inner membrane ring protein [KO:K03222]
DM992_21715  EscR/YscR/HrcR family type III secretion system export apparatus protein [KO:K03226]
DM992_21785  EscS/YscS/HrcS family type III secretion system export apparatus protein [KO:K03227]
DM992_21735  EscT/YscT/HrcT family type III secretion system export apparatus protein [KO:K03228]
DM992_21730  type III secretion protein [KO:K03229]
DM992_21790  EscV/YscV/HrcV family type III secretion system export apparatus protein [KO:K03230]
DM992_21745  EscN/YscN/HrcN family type III secretion system ATPase [KO:K03224] [EC:7.4.2.8]
DM992_21710  YscQ/HrcQ family type III secretion apparatus protein [KO:K03225]
DM992_21750  HrpE/YscL family type III secretion apparatus protein [KO:K03223]
DM992_03610  gspD; type II secretion system protein GspD [KO:K02453]
DM992_31025  general secretion pathway protein GspC [KO:K02452]
DM992_03625  general secretion pathway protein GspC [KO:K02452]
DM992_31020  gspF; type II secretion system protein GspF [KO:K02455]
DM992_03620  gspF; type II secretion system protein GspF [KO:K02455]
DM992_03630  gspG; type II secretion system protein GspG [KO:K02456]
DM992_31030  gspH; type II secretion system protein GspH [KO:K02457]
DM992_03635  gspH; type II secretion system protein GspH [KO:K02457]
DM992_30980  gspI; type II secretion system protein GspI [KO:K02458]
DM992_03640  gspI; type II secretion system protein GspI [KO:K02458]
DM992_30985  type II secretory pathway protein [KO:K02459]
DM992_03645  general secretion pathway protein GspJ [KO:K02459]
DM992_31065  general secretion pathway protein GspK [KO:K02460]
DM992_03650  general secretion pathway protein GspK [KO:K02460]
DM992_03655  gspL; type II secretion system protein GspL [KO:K02461]
DM992_03660  type II secretion system protein M [KO:K02462]
DM992_03615  gspE; type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
DM992_00395  secD; protein translocase subunit SecD [KO:K03072]
DM992_00400  protein translocase subunit SecF [KO:K03074]
DM992_02455  preprotein translocase subunit SecE [KO:K03073]
DM992_08805  preprotein translocase subunit SecG [KO:K03075]
DM992_02280  preprotein translocase subunit SecY [KO:K03076]
DM992_00390  preprotein translocase subunit YajC [KO:K03210]
DM992_03960  membrane protein insertase YidC [KO:K03217]
DM992_01180  preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
DM992_05835  signal recognition particle-docking protein FtsY [KO:K03110]
DM992_05600  protein-export protein SecB [KO:K03071]
DM992_01055  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
DM992_01940  Sec-independent protein translocase subunit TatA [KO:K03116]
DM992_38040  Sec-independent protein translocase subunit TatA [KO:K03116]
DM992_40135  Sec-independent protein translocase subunit TatA [KO:K03116]
DM992_01935  tatB; twin-arginine translocase subunit TatB [KO:K03117]
DM992_01930  tatC; twin-arginine translocase subunit TatC [KO:K03118]
DM992_21720  lytic transglycosylase [KO:K03194]
DM992_36110  lytic transglycosylase [KO:K03194]
DM992_36115  type VI secretion protein [KO:K03197]
DM992_36120  conjugal transfer protein TraD [KO:K03198]
DM992_36135  virB5; P-type DNA transfer protein VirB5 [KO:K03200]
DM992_36150  type IV secretion system protein VirB9 [KO:K03204]
DM992_36130  conjugal transfer protein TraH [KO:K03201]
DM992_36145  type IV secretion system protein [KO:K03203]
DM992_36155  type IV secretion system protein VirB10 [KO:K03195]
DM992_36125  VirB4 family type IV secretion/conjugal transfer ATPase [KO:K03199] [EC:7.4.2.8]
DM992_36160  virB11; P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
DM992_36170  type IV secretory system conjugative DNA transfer family protein [KO:K03205] [EC:7.4.2.8]
DM992_40930  type VI secretion system tip protein VgrG [KO:K11904]
DM992_07335  type VI secretion system tip protein VgrG [KO:K11904]
DM992_13790  type VI secretion system tip protein VgrG [KO:K11904]
DM992_14755  type VI secretion system tip protein VgrG [KO:K11904]
DM992_17985  type VI secretion system tip protein VgrG [KO:K11904]
DM992_22660  type VI secretion system tip protein VgrG [KO:K11904]
DM992_22775  type VI secretion system tip protein VgrG [KO:K11904]
DM992_29580  type VI secretion system tip protein VgrG [KO:K11904]
DM992_35505  type VI secretion system tip protein VgrG [KO:K11904]
DM992_35920  type VI secretion system tip protein VgrG [KO:K11904]
DM992_10540  type VI secretion system tip protein VgrG [KO:K11904]
DM992_14740  type VI secretion system tip protein VgrG [KO:K11904]
DM992_31520  type VI secretion system tip protein VgrG [KO:K11904]
DM992_10465  type VI secretion system tube protein Hcp [KO:K11903]
DM992_29550  type VI secretion system tube protein Hcp [KO:K11903]
DM992_31500  type VI secretion system tube protein Hcp [KO:K11903]
DM992_01680  type VI secretion system tube protein Hcp [KO:K11903]
DM992_10470  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
DM992_18055  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
DM992_29640  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
DM992_31505  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
DM992_01700  tssJ; type VI secretion system lipoprotein TssJ [KO:K11906]
DM992_10485  icmF; type VI secretion system membrane subunit TssM [KO:K11891]
DM992_18040  icmF; type VI secretion system membrane subunit TssM [KO:K11891]
DM992_29620  type VI secretion protein VasK [KO:K11891]
DM992_31560  icmF; type VI secretion system membrane subunit TssM [KO:K11891]
DM992_01640  icmF; type VI secretion system membrane subunit TssM [KO:K11891]
DM992_10480  tssL; type VI secretion system protein TssL [KO:K11892]
DM992_10490  type IV secretion protein DotU [KO:K11892]
DM992_18045  type VI secretion system protein TssL [KO:K11892]
DM992_29560  DotU family type IV/VI secretion system protein [KO:K11892]
DM992_31555  tssL; type VI secretion system protein TssL [KO:K11892]
DM992_31565  type IV secretion protein DotU [KO:K11892]
DM992_01710  DotU family type IV/VI secretion system protein [KO:K11892]
DM992_10450  clpV; type VI secretion system ATPase TssH [KO:K11907]
DM992_17990  clpV; type VI secretion system ATPase TssH [KO:K11907]
DM992_29545  clpV; type VI secretion system ATPase TssH [KO:K11907]
DM992_31485  clpV; type VI secretion system ATPase TssH [KO:K11907]
DM992_01660  clpV; type VI secretion system ATPase TssH [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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