KEGG   PATHWAY: bvj00300
Entry
bvj00300                    Pathway                                
Name
Lysine biosynthesis - Heyndrickxia vini
Class
Metabolism; Amino acid metabolism
Pathway map
bvj00300  Lysine biosynthesis
bvj00300

Module
bvj_M00525  Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine [PATH:bvj00300]
bvj_M00527  Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:bvj00300]
Other DBs
GO: 0009085
Organism
Heyndrickxia vini [GN:bvj]
Gene
I5776_16295  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
I5776_04980  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
I5776_07160  aspartate kinase [KO:K00928] [EC:2.7.2.4]
I5776_12440  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
I5776_17930  aspartate kinase [KO:K00928] [EC:2.7.2.4]
I5776_12445  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
I5776_12435  dapA; 4-hydroxy-tetrahydrodipicolinate synthase [KO:K01714] [EC:4.3.3.7]
I5776_15200  hpaI; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [KO:K01714] [EC:4.3.3.7]
I5776_09215  4-hydroxy-tetrahydrodipicolinate reductase [KO:K00215] [EC:1.17.1.8]
I5776_11995  acetylornithine transaminase [KO:K00821] [EC:2.6.1.11 2.6.1.17]
I5776_06605  pepV; dipeptidase PepV [KO:K01439] [EC:3.5.1.18]
I5776_09665  diaminopimelate epimerase [KO:K01778] [EC:5.1.1.7]
I5776_17775  LL-diaminopimelate aminotransferase [KO:K10206] [EC:2.6.1.83]
I5776_08865  lysA; diaminopimelate decarboxylase [KO:K01586] [EC:4.1.1.20]
I5776_13585  dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase [KO:K05822] [EC:2.3.1.89]
I5776_13660  aminotransferase A [KO:K00841] [EC:2.6.1.-]
I5776_13580  N-acetyldiaminopimelate deacetylase [KO:K05823] [EC:3.5.1.47]
I5776_13200  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [KO:K01928] [EC:6.3.2.13]
I5776_19740  UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [KO:K01929] [EC:6.3.2.10]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00047  L-Lysine
C00049  L-Aspartate
C00263  L-Homoserine
C00322  2-Oxoadipate
C00441  L-Aspartate 4-semialdehyde
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00666  LL-2,6-Diaminoheptanedioate
C00680  meso-2,6-Diaminoheptanedioate
C00956  L-2-Aminoadipate
C01251  (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C03082  4-Phospho-L-aspartate
C03871  L-2-Amino-6-oxoheptanedioate
C03972  2,3,4,5-Tetrahydrodipicolinate
C04002  (Z)-But-1-ene-1,2,4-tricarboxylate
C04076  L-2-Aminoadipate 6-semialdehyde
C04390  N6-Acetyl-LL-2,6-diaminoheptanedioate
C04421  N-Succinyl-LL-2,6-diaminoheptanedioate
C04462  N-Succinyl-2-L-amino-6-oxoheptanedioate
C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05535  alpha-Aminoadipoyl-S-acyl enzyme
C05539  N-Acetyl-L-2-amino-6-oxopimelate
C05560  L-2-Aminoadipate adenylate
C05662  Homoisocitrate
C16138  L-Pyrrolysine
C19886  LysW-gamma-L-alpha-aminoadipate
C19887  LysW-gamma-L-alpha-aminoadipyl 6-phosphate
C19888  LysW-gamma-L-alpha-aminoadipate 6-semialdehyde
C19889  LysW-gamma-L-lysine
C20258  (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
C20277  (2R,3R)-3-Methylornithine
C20278  (2R,3R)-3-Methylornithinyl-N6-lysine
C20279  (2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine
Reference
  Authors
Ledwidge R, Blanchard JS.
  Title
The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.
  Journal
Biochemistry 38:3019-3024 (1999)
DOI:10.1021/bi982574a
Reference
  Authors
Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R.
  Title
Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase.
  Journal
J Bacteriol 182:3626-3631 (2000)
DOI:10.1128/JB.182.13.3626-3631.2000
Reference
  Authors
Zabriskie TM, Jackson MD.
  Title
Lysine biosynthesis and metabolism in fungi.
  Journal
Nat Prod Rep 17:85-97 (2000)
DOI:10.1039/A801345D
Reference
  Authors
Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
  Title
Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
  Journal
Nucleic Acids Res 31:6748-57 (2003)
DOI:10.1093/nar/gkg900
Reference
  Authors
Velasco AM, Leguina JI, Lazcano A.
  Title
Molecular evolution of the lysine biosynthetic pathways.
  Journal
J Mol Evol 55:445-59 (2002)
DOI:10.1007/s00239-002-2340-2
Reference
  Authors
Miyazaki T, Miyazaki J, Yamane H, Nishiyama M.
  Title
alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.
  Journal
Microbiology 150:2327-34 (2004)
DOI:10.1099/mic.0.27037-0
Reference
  Authors
Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.
  Title
Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
  Journal
Mol Genet Metab 76:172-80 (2002)
DOI:10.1016/S1096-7192(02)00037-9
Reference
  Authors
Nishiyama M.
  Title
[Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways]
  Journal
Tanpakushitsu Kakusan Koso 49:758-63 (2004)
Reference
  Authors
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
  Title
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
  Journal
Genome Res 9:1175-83 (1999)
DOI:10.1101/gr.9.12.1175
Reference
  Authors
Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S.
  Title
Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8.
  Journal
J Mol Biol 332:729-40 (2003)
DOI:10.1016/S0022-2836(03)00946-X
Reference
  Authors
Hudson AO, Singh BK, Leustek T, Gilvarg C.
  Title
An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.
  Journal
Plant Physiol 140:292-301 (2006)
DOI:10.1104/pp.105.072629
Reference
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
Reference
  Authors
Dairi T, Kuzuyama T, Nishiyama M, Fujii I
  Title
Convergent strategies in biosynthesis.
  Journal
Nat Prod Rep 28:1054-86 (2011)
DOI:10.1039/c0np00047g
Reference
  Authors
Gaston MA, Jiang R, Krzycki JA
  Title
Functional context, biosynthesis, and genetic encoding of pyrrolysine.
  Journal
Curr Opin Microbiol 14:342-9 (2011)
DOI:10.1016/j.mib.2011.04.001
Related
pathway
bvj00010  Glycolysis / Gluconeogenesis
bvj00020  Citrate cycle (TCA cycle)
bvj00250  Alanine, aspartate and glutamate metabolism
bvj00260  Glycine, serine and threonine metabolism
bvj00310  Lysine degradation
bvj00550  Peptidoglycan biosynthesis
bvj00620  Pyruvate metabolism
KO pathway
ko00300   
LinkDB

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