Entry Name Lysine biosynthesis
Class Metabolism; Amino acid metabolismBRITE hierarchy
Pathway map Module M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:ko00300 ]
M00030 Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine [PATH:ko00300 ]
M00031 Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine [PATH:ko00300 ]
M00433 Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate [PATH:ko00300 ]
M00525 Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine [PATH:ko00300 ]
M00526 Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine [PATH:ko00300 ]
M00527 Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:ko00300 ]
M00608 2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate [PATH:ko00300 ]
Other DBs Orthology K00290 LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7 ]
K00293 LYS9; saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10 ]
K00674 dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117 ]
K00841 patA; aminotransferase [EC:2.6.1.-]
K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7 ]
K01798 alr-murF; Alr-MurF fusion protein
K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13 ]
K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10 ]
K05822 dapH, dapD; tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89 ]
K05825 LYSN; 2-aminoadipate transaminase [EC:2.6.1.-]
K05827 lysX; [lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase [EC:6.3.2.43 ]
K05829 lysY, argC; [amino group carrier protein]-6-phospho-L-2-aminoadipate/5-phospho-L-glutamate reductase [EC:1.2.1.103 1.2.1.106 ]
K05830 lysJ, argD; [amino-group carrier protein]-gamma-(L-lysyl/L-ornithyl)-L-glutamate aminotransferase [EC:2.6.1.118 2.6.1.124 ]
K10978 aksF; methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K16182 pylD; 3-methylornithyl-N6-L-lysine dehydrogenase [EC:1.4.1.-]
K17450 ACO2; homoaconitase [EC:4.2.1.-]
K24034 SPE3-LYS9; spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
K25032 K25032 ; alpha-aminoadipate-LysW ligase/glutamate-LysW ligase
Compound C00441 L-Aspartate 4-semialdehyde
C00449 N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00666 LL-2,6-Diaminoheptanedioate
C00680 meso-2,6-Diaminoheptanedioate
C01251 (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C03871 L-2-Amino-6-oxoheptanedioate
C03972 2,3,4,5-Tetrahydrodipicolinate
C04002 (Z)-But-1-ene-1,2,4-tricarboxylate
C04076 L-2-Aminoadipate 6-semialdehyde
C04390 N6-Acetyl-LL-2,6-diaminoheptanedioate
C04421 N-Succinyl-LL-2,6-diaminoheptanedioate
C04462 N-Succinyl-2-L-amino-6-oxoheptanedioate
C04877 UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05535 alpha-Aminoadipoyl-S-acyl enzyme
C05539 N-Acetyl-L-2-amino-6-oxopimelate
C05560 L-2-Aminoadipate adenylate
C19886 LysW-gamma-L-alpha-aminoadipate
C19887 LysW-gamma-L-alpha-aminoadipyl 6-phosphate
C19888 LysW-gamma-L-alpha-aminoadipate 6-semialdehyde
C20258 (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
C20277 (2R,3R)-3-Methylornithine
C20278 (2R,3R)-3-Methylornithinyl-N6-lysine
C20279 (2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine
Reference Authors Ledwidge R, Blanchard JS.
Title The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.
Journal Reference Authors Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R.
Title Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase.
Journal Reference Authors Zabriskie TM, Jackson MD.
Title Lysine biosynthesis and metabolism in fungi.
Journal Reference Authors Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
Title Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
Journal Reference Authors Velasco AM, Leguina JI, Lazcano A.
Title Molecular evolution of the lysine biosynthetic pathways.
Journal Reference Authors Miyazaki T, Miyazaki J, Yamane H, Nishiyama M.
Title alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.
Journal Reference Authors Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.
Title Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
Journal Reference Authors Nishiyama M.
Title [Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways]
Journal Tanpakushitsu Kakusan Koso 49:758-63 (2004)
Reference Authors Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
Title A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
Journal Reference Authors Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S.
Title Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8.
Journal Reference Authors Hudson AO, Singh BK, Leustek T, Gilvarg C.
Title An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.
Journal Reference Authors Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
Title Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
Journal Reference Authors Dairi T, Kuzuyama T, Nishiyama M, Fujii I
Title Convergent strategies in biosynthesis.
Journal Reference Authors Gaston MA, Jiang R, Krzycki JA
Title Functional context, biosynthesis, and genetic encoding of pyrrolysine.
Journal Related ko00010 Glycolysis / Gluconeogenesis
ko00250 Alanine, aspartate and glutamate metabolism
ko00260 Glycine, serine and threonine metabolism
ko00960 Tropane, piperidine and pyridine alkaloid biosynthesis
