KEGG   PATHWAY: cbal00260
Entry
cbal00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Cellulophaga baltica NN016038
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
cbal00260  Glycine, serine and threonine metabolism
cbal00260

Module
cbal_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cbal00260]
cbal_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:cbal00260]
cbal_M00621  Glycine cleavage system [PATH:cbal00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cellulophaga baltica NN016038 [GN:cbal]
Gene
M667_06770  aspartate kinase [KO:K00928] [EC:2.7.2.4]
M667_11575  aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
M667_08105  aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
M667_04365  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
M667_11570  serine kinase [KO:K00872] [EC:2.7.1.39]
M667_11555  threonine synthase [KO:K01733] [EC:4.2.3.1]
M667_13975  threonine aldolase [KO:K01620] [EC:4.1.2.48]
M667_15015  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
M667_15765  glycerate kinase [KO:K00865] [EC:2.7.1.165]
M667_08720  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
M667_17370  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M667_17955  3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M667_06790  2-hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
M667_17365  MFS transporter [KO:K00831] [EC:2.6.1.52]
M667_03990  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
M667_04185  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
M667_14010  8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
M667_04525  amine oxidoreductase [KO:K00274] [EC:1.4.3.4]
M667_01555  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
M667_11540  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
M667_11300  hypothetical protein [KO:K00382] [EC:1.8.1.4]
M667_14840  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
M667_07670  glycine cleavage system protein H [KO:K02437]
M667_10560  phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
M667_14005  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
M667_03840  cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
M667_13765  serine dehydratase [KO:K01752] [EC:4.3.1.17]
M667_14965  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
M667_09095  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
M667_09100  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
cbal00010  Glycolysis / Gluconeogenesis
cbal00020  Citrate cycle (TCA cycle)
cbal00230  Purine metabolism
cbal00250  Alanine, aspartate and glutamate metabolism
cbal00270  Cysteine and methionine metabolism
cbal00290  Valine, leucine and isoleucine biosynthesis
cbal00300  Lysine biosynthesis
cbal00330  Arginine and proline metabolism
cbal00460  Cyanoamino acid metabolism
cbal00470  D-Amino acid metabolism
cbal00564  Glycerophospholipid metabolism
cbal00600  Sphingolipid metabolism
cbal00620  Pyruvate metabolism
cbal00630  Glyoxylate and dicarboxylate metabolism
cbal00640  Propanoate metabolism
cbal00680  Methane metabolism
cbal00860  Porphyrin metabolism
cbal00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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