KEGG   PATHWAY: ccan04980
Entry
ccan04980                   Pathway                                
Name
Cobalamin transport and metabolism - Castor canadensis (American beaver)
Class
Organismal Systems; Digestive system
Pathway map
ccan04980  Cobalamin transport and metabolism
ccan04980

Organism
Castor canadensis (American beaver) [GN:ccan]
Gene
109696058  transcobalamin-1-like [KO:K25741]
109696435  transcobalamin-1-like [KO:K25741]
109695332  transcobalamin-1-like [KO:K25741]
109696356  Gif; gastric intrinsic factor [KO:K14615]
109696782  Tcn2; transcobalamin-2 [KO:K14619]
109698444  Cd320; CD320 antigen isoform X1 [KO:K06734]
109683452  Lmbrd1; probable lysosomal cobalamin transporter [KO:K14617]
109688408  Abcd4; LOW QUALITY PROTEIN: ATP-binding cassette sub-family D member 4 [KO:K05678] [EC:7.6.2.8]
109701349  methylmalonic aciduria and homocystinuria type C protein homolog [KO:K14618] [EC:1.16.1.6 2.5.1.151]
109686603  methylmalonic aciduria and homocystinuria type C protein homolog [KO:K14618] [EC:1.16.1.6 2.5.1.151]
109698267  Mmadhc; methylmalonic aciduria and homocystinuria type D protein, mitochondrial [KO:K26006]
109690554  Mmab; cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial isoform X1 [KO:K00798] [EC:2.5.1.17]
109699352  Mmaa; methylmalonic aciduria type A protein, mitochondrial [KO:K07588] [EC:3.6.5.-]
109690978  Mut; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
109688199  Mtrr; methionine synthase reductase isoform X1 [KO:K00597] [EC:1.16.1.8]
109682326  Mtr; methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
109689847  Znf76; zinc finger protein 76 isoform X1 [KO:K20828]
109696833  Znf143; LOW QUALITY PROTEIN: zinc finger protein 143 [KO:K20828]
109701932  Hcfc1; host cell factor 1 isoform X1 [KO:K14966]
109691276  Thap11; THAP domain-containing protein 11 [KO:K23211]
109686604  peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews(1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
ccan00270  Cysteine and methionine metabolism
ccan00280  Valine, leucine and isoleucine degradation
ccan00670  One carbon pool by folate
ccan04144  Endocytosis
ccan04977  Vitamin digestion and absorption
KO pathway
ko04980   
LinkDB

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