Entry
Name
Peptidoglycan biosynthesis - Clostridioides difficile 630
Description
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
Ortholog table
Organism
Clostridioides difficile 630 [GN:
cdf ]
Gene
CD630_35180 murC; UDP-N-acetylmuramate--L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase) [KO:K01924 ] [EC:6.3.2.8 ]
CD630_26530 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase) (D-glutamic acid-adding enzyme) [KO:K01925 ] [EC:6.3.2.9 ]
CD630_26550 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (UDP-MurNAc-pentapeptide synthetase) (D-alanyl-D-alanine-adding enzyme) [KO:K01929 ] [EC:6.3.2.10 ]
CD630_13320 uppP1; Undecaprenyl-diphosphatase 1 (Undecaprenyl pyrophosphate phosphatase 1) (Bacitracin resistance protein 1) [KO:K06153 ] [EC:3.6.1.27 ]
CD630_29860 uppP2; Undecaprenyl-diphosphatase 2 (Undecaprenyl pyrophosphate phosphatase 2) (Bacitracin resistance protein 2) [KO:K06153 ] [EC:3.6.1.27 ]
CD630_26540 mraY; Phospho-N-acetylmuramoyl-pentapeptide-transferase (UDP-MurNAc-pentapeptide phosphotransferase) [KO:K01000 ] [EC:2.7.8.13 ]
CD630_26510 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [KO:K02563 ] [EC:2.4.1.227 ]
CD630_26560 spoVD; Stage V sporulation protein D (Sporulation-specific penicillin-binding protein) [KO:K08384 ]
CD630_24980 dacF1; D-alanyl-D-alanine carboxypeptidase (putative sporulation-specific penicillin-binding protein) [KO:K07258 ] [EC:3.4.16.4 ]
Compound
C00043 UDP-N-acetyl-alpha-D-glucosamine
C00448 trans,trans-Farnesyl diphosphate
C00692 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C01212 UDP-N-acetylmuramoyl-L-alanine
C04574 di-trans,poly-cis-Undecaprenyl diphosphate
C04631 UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702 UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851 MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877 UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892 UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896 Crosslinked peptidoglycan
C05897 Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556 di-trans,poly-cis-Undecaprenyl phosphate
C17558 di-trans,poly-cis-Undecaprenol
C22053 UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Reference
Authors
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
Title
The biosynthesis of peptidoglycan lipid-linked intermediates.
Journal
Reference
Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
Journal
Reference
Authors
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
Title
Cytoplasmic steps of peptidoglycan biosynthesis.
Journal
Reference
Authors
van Heijenoort J
Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
Journal
Reference
Authors
van Heijenoort J
Title
Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
Journal
Related pathway
cdf00520 Amino sugar and nucleotide sugar metabolism
cdf00900 Terpenoid backbone biosynthesis
KO pathway
LinkDB
All DBs