KEGG PATHWAY: cdv00260

PATHWAY: cdv00260

Entry

cdv00260                    Pathway

Name

Glycine, serine and threonine metabolism - Corynebacterium diphtheriae VA01

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

cdv00260

Glycine, serine and threonine metabolism

Module

cdv_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:cdv00260]

cdv_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:cdv00260]

cdv_M00555

Betaine biosynthesis, choline => betaine [PATH:cdv00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Corynebacterium diphtheriae VA01 [GN:cdv]

Gene

CDVA01_0176

lysC; aspartate kinase [KO:K00928] [EC:2.7.2.4]

CDVA01_0179

aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

CDVA01_0907

hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

CDVA01_0908

thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]

CDVA01_1525

thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]

CDVA01_0805

glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

CDVA01_1423

putative glycerate kinase [KO:K00865] [EC:2.7.1.165]

CDVA01_0282

gpmA; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

CDVA01_0977

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

CDVA01_0670

serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

CDVA01_1710

serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

CDVA01_0260

lpd; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

CDVA01_2014

betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]

CDVA01_2012

gbsA; betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]

CDVA01_1226

sdaB; L-serine dehydratase [KO:K01752] [EC:4.3.1.17]

CDVA01_0379

sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]

CDVA01_1453

ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]

CDVA01_2176

trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]

CDVA01_2166

trpB1; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]

CDVA01_2175

trpB2; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721