KEGG   PATHWAY: eai00591
Entry
eai00591                    Pathway                                
Name
Linoleic acid metabolism - Equus asinus (ass)
Class
Metabolism; Lipid metabolism
Pathway map
eai00591  Linoleic acid metabolism
eai00591

Other DBs
GO: 0043651
Organism
Equus asinus (ass) [GN:eai]
Gene
106826933  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
106845081  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
106842401  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
106839799  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
106839801  PLA2G2A; phospholipase A2, membrane associated isoform X2 [KO:K01047] [EC:3.1.1.4]
106839803  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
106839804  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
106839805  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
106839807  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
106844787  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
106847166  group 10 secretory phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
106841342  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
106841343  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
106841344  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
106841348  PLA2G4B; cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
106846782  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
106837612  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
106837073  PLB1; phospholipase B1, membrane-associated isoform X2 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
106833654  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
106827942  phospholipase A and acyltransferase 2-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
106827943  PLAAT2; phospholipase A and acyltransferase 2 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
106844159  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
106831265  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
106842116  LOW QUALITY PROTEIN: cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
106846703  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
106846096  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
106842115  LOW QUALITY PROTEIN: cytochrome P450 2C21-like [KO:K07413] [EC:1.14.14.1]
106828038  cytochrome P450 2C18-like [KO:K07413] [EC:1.14.14.1]
106842117  cytochrome P450 2C19-like isoform X1 [KO:K07413] [EC:1.14.14.1]
106842118  cytochrome P450 2C42-like [KO:K07413] [EC:1.14.14.1]
106846082  cytochrome P450 2C42-like isoform X1 [KO:K07413] [EC:1.14.14.1]
106833456  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
106841091  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
106825167  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
106825164  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
106832276  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
106832277  cytochrome P450 3A12 [KO:K07424] [EC:1.14.14.1]
106832275  cytochrome P450 3A12-like [KO:K07424] [EC:1.14.14.1]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C01595  Linoleate
C03242  Dihomo-gamma-linolenate
C04056  Rumenic acid
C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
C07289  Crepenynate
C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  (7S,8S)-DiHODE
C14762  13(S)-HODE
C14765  13-OxoODE
C14766  9-OxoODE
C14767  9(S)-HODE
C14825  9(10)-EpOME
C14826  12(13)-EpOME
C14827  9(S)-HPODE
C14828  9,10-DHOME
C14829  12,13-DHOME
C14831  8(R)-HPODE
C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  9,12,13-TriHOME
C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  9,10,13-TriHOME
C14836  9,10-12,13-Diepoxyoctadecanoate
C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  5S,8R-DiHODE
C22918  (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
DOI:10.1016/j.toxlet.2003.11.002
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
DOI:10.1073/pnas.1631086100
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
DOI:10.1054/plef.2002.0413
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
DOI:10.1074/jbc.273.33.20744
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
DOI:10.1104/pp.110.3.807
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
DOI:10.1016/0304-4165(96)00037-2
Related
pathway
eai00590  Arachidonic acid metabolism
KO pathway
ko00591   
LinkDB

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