KEGG   PATHWAY: eco00450
Entry
eco00450                    Pathway                                
Name
Selenocompound metabolism - Escherichia coli K-12 MG1655
Class
Metabolism; Metabolism of other amino acids
Pathway map
eco00450  Selenocompound metabolism
eco00450

Organism
Escherichia coli K-12 MG1655 [GN:eco]
Gene
b3939  metB; O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase [KO:K01739] [EC:2.5.1.48]
b3008  metC; cystathionine beta-lyase/L-cysteine desulfhydrase/alanine racemase [KO:K01760] [EC:4.4.1.13]
b1622  malY; negative regulator of MalT activity/cystathionine beta-lyase [KO:K14155] [EC:4.4.1.13]
b4019  metH; cobalamin-dependent methionine synthase [KO:K00548] [EC:2.1.1.13]
b3829  metE; cobalamin-independent homocysteine transmethylase [KO:K00549] [EC:2.1.1.14]
b1680  sufS; L-cysteine desulfurase [KO:K11717] [EC:2.8.1.7 4.4.1.16]
b0888  trxB; thioredoxin reductase [KO:K00384] [EC:1.8.1.9]
b1587  ynfE; putative selenate reductase YnfE [KO:K07309] [EC:1.97.1.9]
b1588  ynfF; putative selenate reductase YnfF [KO:K07310] [EC:1.97.1.9]
b2878  ygfK; putative oxidoreductase, Fe-S subunit [KO:K12527] [EC:1.97.1.9]
b2881  xdhD; fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit [KO:K12528]
b2880  ygfM; putative oxidoreductase [KO:K12529]
b2751  cysN; sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
b2752  cysD; sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
b1764  selD; selenide, water dikinase [KO:K01008] [EC:2.7.9.3]
b3591  selA; selenocysteine synthase [KO:K01042] [EC:2.9.1.1]
b2114  metG; methionine--tRNA ligase [KO:K01874] [EC:6.1.1.10]
Compound
C00017  Protein
C00041  L-Alanine
C01528  Hydrogen selenide
C02535  Dimethyl selenide
C05172  Selenophosphoric acid
C05335  L-Selenomethionine
C05336  Selenomethionyl-tRNA(Met)
C05684  Selenite
C05686  Adenylylselenate
C05688  L-Selenocysteine
C05689  Se-Methyl-L-selenocysteine
C05690  Se-Methylselenomethionine
C05695  gamma-Glutamyl-Se-methylselenocysteine
C05697  Selenate
C05698  Selenohomocysteine
C05699  L-Selenocystathionine
C05703  Methaneselenol
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16638  O-Phosphoseryl-tRNA(Sec)
C18870  Selenodiglutathione
C18871  Glutathioselenol
C18872  Trimethylselenonium
C18893  1-Methylseleno-N-acetyl-D-galactosamine
C18902  Methylselenic acid
C18904  Methylselenopyruvate
C18905  Methylselenocysteine Se-oxide
Reference
PMID:21190829
  Authors
Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
  Title
Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
  Journal
J Nutr Biochem 22:945-55 (2011)
DOI:10.1016/j.jnutbio.2010.08.006
Reference
PMID:19051051
  Authors
McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
  Title
Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
  Journal
Transgenic Res 18:407-24 (2009)
DOI:10.1007/s11248-008-9233-0
Reference
PMID:20383543
  Authors
Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
  Title
Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
  Journal
Amino Acids 41:29-41 (2011)
DOI:10.1007/s00726-010-0578-3
Reference
PMID:17451884
  Authors
Suzuki KT, Kurasaki K, Suzuki N
  Title
Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
  Journal
Biochim Biophys Acta 1770:1053-61 (2007)
DOI:10.1016/j.bbagen.2007.03.007
Reference
PMID:11782468
  Authors
Gromer S, Gross JH
  Title
Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
  Journal
J Biol Chem 277:9701-6 (2002)
DOI:10.1074/jbc.M109234200
KO pathway
ko00450   
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