Entry Name Two-component system - Escherichia coli O157:H7 Sakai (EHEC)
Description Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Escherichia coli O157:H7 Sakai (EHEC) [GN:
ecs ]
Gene ECs_0449 phoB; two-component regulatory system response regulator PhoB [KO:K07657 ]
ECs_4664 pstS; phosphate ABC transporter periplasmic binding protein [KO:K02040 ]
ECs_1602 phoP; two-component regulatory system response regulator PhoP [KO:K07660 ]
ECs_4247 ompR; two-component regulatory system response regulator OmpR [KO:K07659 ]
ECs_4838 cpxR; two-component regulatory system response regulator CpxR [KO:K07662 ]
ECs_2314 rstA; two-component regulatory system response regulator rstA [KO:K07661 ]
ECs_5356 creB; two-component regulatory system response regulator CreR [KO:K07663 ]
ECs_2887 baeR; two-component regulatory system response regulator BaeR [KO:K07664 ]
ECs_5095 basR; two-component regulatory system response regulator BasR [KO:K07771 ]
ECs_3141 arnB; uridine 5'-(beta-1-threo-pentapyranosyl-4-ulose diphosphate) aminotransferase [KO:K07806 ] [EC:2.6.1.87 ]
ECs_0608 cusS; copper-sensing histidine kinase in two-component regulatory system with CusR [KO:K07644 ] [EC:2.7.13.3 ]
ECs_0609 cusR; two-component regulatory system response regulator CusR [KO:K07665 ]
ECs_0610 cusC; outer membrane component of copper/silver efflux system [KO:K07796 ]
ECs_0611 cusF; Cu(I)/Ag(I) efflux system periplasmic protein CusF [KO:K07810 ]
ECs_0612 cusB; membrane fusion protein of copper/silver efflux system [KO:K07798 ]
ECs_3908 qseC; quorum sensing sensory histidine kinase in two-component regulatory system with QseB [KO:K07645 ] [EC:2.7.13.3 ]
ECs_3907 qseB; quorum sensing DNA-binding response regulator in two-component regulatory system with QseC [KO:K07666 ]
ECs_2602 flhD; flagellar class II regulon transcriptional activator [KO:K02403 ]
ECs_2601 flhC; flagellar class II regulon transcriptional activator [KO:K02402 ]
ECs_0722 kdpE; two-component regulatory system response regulator KdpE [KO:K07667 ]
ECs_1148 torS; hybrid sensory histidine kinase in two-component regulatory system with TorR [KO:K07647 ] [EC:2.7.13.3 ]
ECs_1150 torR; two-component regulatory system response regulator TorR [KO:K07772 ]
ECs_1151 torC; trimethylamine N-oxidoreductase I cytochrome c-type subunit [KO:K03532 ]
ECs_5359 arcA; two-component regulatory system response regulator [KO:K07773 ]
ECs_4637 dnaA; chromosomal replication initiator protein DnaA [KO:K02313 ]
ECs_0623 fepA; ferrienterobactin outer membrane transporter [KO:K19611 ]
ECs_0658 citA; sensory histidine kinase in two-component regulatory system with CitB [KO:K07700 ] [EC:2.7.13.3 ]
ECs_0659 citB; response regulator in two-component regulatory system with CitA [KO:K07702 ]
ECs_5106 dcuR; two-component regulatory system response regulator DcuR [KO:K07703 ]
ECs_5105 dcuB; anaerobic C4-dicarboxylate transporter DcuB [KO:K07792 ]
ECs_1726 narL; two-component regulatory system response regulator NarL [KO:K07684 ]
ECs_3331 narQ; sensory histidine kinase in two-component regulatory system with NarP [KO:K07674 ] [EC:2.7.13.3 ]
ECs_3082 narP; two-component regulatory system response regulator NarP [KO:K07685 ]
ECs_1731 narJ; molybdenum-cofactor-assembly chaperone delta subunit of nitrate reductase 1 [KO:K00373 ]
ECs_5135 frdA; anaerobic fumarate reductase catalytic and NAD/flavoprotein subunit [KO:K00244 ] [EC:1.3.5.1 ]
ECs_4606 uhpA; two-component regulatory system response regulator UhpA [KO:K07686 ]
ECs_3107 rcsC; hybrid sensory kinase in two-component regulatory system with RcsB and YojN [KO:K07677 ] [EC:2.7.13.3 ]
ECs_3105 rcsD; phosphotransfer intermediate protein in two-component regulatory system with RcsBC [KO:K07676 ] [EC:2.7.13.3 ]
ECs_3106 rcsB; two-component regulatory system response regulator RcsB [KO:K07687 ]
ECs_2652 uvrY; two-component regulatory system response regulator UvrY [KO:K07689 ]
ECs_3553 csrA; pleiotropic regulatory protein for carbon source metabolism [KO:K03563 ]
ECs_3249 evgS; hybrid sensory histidine kinase in two-component regulatory system with EvgA [KO:K07679 ] [EC:2.7.13.3 ]
ECs_3248 evgA; two-component regulatory system response regulator EvgA [KO:K07690 ]
ECs_3247 emrK; multidrug resistance efflux pump membrane fusion protein [KO:K07797 ]
ECs_2105 safA; two-component system connector membrane protein [KO:K23236 ]
ECs_3420 glrR; two-component regulatory system response regulator glrR [KO:K07715 ]
ECs_2592 cheY; chemotaxis regulator transmitting signal to flagellar motor component [KO:K03413 ]
ECs_0692 gltK; glutamate/aspartate ABC transporter permease [KO:K10002 ]
ECs_0693 gltJ; glutamate/aspartate ABC transporter permease [KO:K10003 ]
ECs_0694 gltI; glutamate/aspartate periplasmic binding protein [KO:K10001 ]
ECs_1139 gfcE; O-antigen capsule outer membrane auxiliary protein export channel [KO:K01991 ]
Compound C05757 (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C11842 N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849 3-Hydroxy-palmitic acid methyl ester
C16665 12-Methyltetradecanoic acid
C18206 cis-11-Methyl-2-dodecenoic acid
Reference Authors Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
Title Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
Journal Reference Authors Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
Title Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
Journal Reference Authors Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
Title Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
Journal Reference Authors Cai SJ, Inouye M.
Title EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
Journal Reference Authors Batchelor E, Walthers D, Kenney LJ, Goulian M.
Title The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
Journal Reference Authors Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
Title The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
Journal Reference Authors Hagiwara D, Yamashino T, Mizuno T.
Title A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
Journal Reference Authors Munson GP, Lam DL, Outten FW, O'Halloran TV.
Title Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
Journal Reference Authors Sperandio V, Torres AG, Kaper JB.
Title Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
Journal Reference Authors Epstein W.
Title The roles and regulation of potassium in bacteria.
Journal Reference Authors Ansaldi M, Simon G, Lepelletier M, Mejean V.
Title The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
Journal Reference Authors Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
Title Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
Journal Reference Authors Widenhorn KA, Somers JM, Kay WW.
Title Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
Journal Reference Authors Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
Title A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
Journal Reference Authors Zhang X, Hulett FM.
Title ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
Journal Reference Authors Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
Title A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
Journal Reference Authors He H, Zahrt TC.
Title Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
Journal Reference Authors Hutchings MI
Title Unusual two-component signal transduction pathways in the actinobacteria.
Journal Reference Authors Kramer R
Title Osmosensing and osmosignaling in Corynebacterium glutamicum.
Journal Reference Authors Eraso JM, Kaplan S.
Title Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
Journal Reference Authors Haydel SE, Dunlap NE, Benjamin WH Jr.
Title In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
Journal Reference Authors Quisel JD, Burkholder WF, Grossman AD.
Title In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
Journal Reference Authors Kaspar S, Bott M.
Title The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
Journal Reference Authors Janausch IG, Garcia-Moreno I, Unden G.
Title Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
Journal Reference Authors Brunskill EW, Bayles KW.
Title Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
Journal Reference Authors Fujimoto DF, Brunskill EW, Bayles KW.
Title Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
Journal Reference Authors Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
Title High genetic variability of the agr locus in Staphylococcus species.
Journal Reference Authors Rabin RS, Stewart V.
Title Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
Journal Reference Authors Chiang RC, Cavicchioli R, Gunsalus RP.
Title 'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
Journal Reference Authors Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
Title Cooperativity in signal transfer through the Uhp system of Escherichia coli.
Journal Reference Authors Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
Title Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
Journal Reference Authors Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
Title Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
Journal Reference Authors Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
Title Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
Journal Reference Authors Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
Title Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
Journal Reference Authors Ansaldi M, Dubnau D.
Title Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
Journal Reference Authors Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
Title Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
Journal Reference Authors Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
Title Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
Journal Reference Authors Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
Title Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
Journal Reference Authors Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
Title DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
Journal Reference Authors Fedtke I, Kamps A, Krismer B, Gotz F.
Title The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
Journal Reference Authors Shiau SP, Chen P, Reitzer LJ.
Title Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
Journal Reference Authors Leonhartsberger S, Huber A, Lottspeich F, Bock A.
Title The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
Journal Reference Authors Lioliou EE, Kyriakidis DA.
Title The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
Journal Reference Authors Yamamoto K, Ishihama A
Title Transcriptional response of Escherichia coli to external copper.
Journal Reference Authors Ashby MK, Mullineaux CW
Title Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
Journal Reference Authors Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
Title A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
Journal Reference Authors Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
Title The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
Journal Reference Authors Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
Title Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
Journal Reference Authors Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
Title Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
Journal Reference Authors Yeh KC, Wu SH, Murphy JT, Lagarias JC
Title A cyanobacterial phytochrome two-component light sensory system.
Journal Reference Authors Niu S, Jiang SQ, Hong J
Title Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
Journal Reference Authors Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
Title A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
Journal Reference Authors Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
Title C4-dicarboxylate carriers and sensors in bacteria.
Journal Reference Authors Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
Title C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
Journal Reference Authors Novick RP, Jiang D
Title The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
Journal Reference Authors Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
Title The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
Journal Reference Authors Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
Title Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
Journal Reference Authors Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
Title Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
Journal Reference Authors Yoshihara S, Ikeuchi M.
Title Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
Journal Reference Authors Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
Title A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
Journal Reference Authors Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
Title A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
Journal Reference Authors Mascher T, Zimmer SL, Smith TA, Helmann JD
Title Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
Journal Reference Authors Hyyrylainen HL, Sarvas M, Kontinen VP
Title Transcriptome analysis of the secretion stress response of Bacillus subtilis.
Journal Reference Authors Serizawa M, Sekiguchi J
Title The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
Journal Reference Authors Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
Title The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
Journal Reference Authors Ogura M, Tsukahara K, Hayashi K, Tanaka T
Title The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
Journal Reference Authors Yamamoto H, Murata M, Sekiguchi J
Title The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
Journal Reference Authors Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
Title Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
Journal Reference Authors Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
Title The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
Journal Reference Authors Tanaka K, Kobayashi K, Ogasawara N
Title The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
Journal Reference Authors Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
Title Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
Journal Reference Authors Hamblin MJ, Shaw JG, Kelly DJ
Title Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
Journal Reference Authors Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
Title TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
Journal Reference Authors Martin B, Quentin Y, Fichant G, Claverys JP
Title Independent evolution of competence regulatory cascades in streptococci?
Journal Reference Authors Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
Title The genetic basis of tetrathionate respiration in Salmonella typhimurium.
Journal Reference Authors Guvener ZT, Harwood CS
Title Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
Journal Reference Authors Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
Title Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.
Journal Reference Authors Jiang M, Shao W, Perego M, Hoch JA
Title Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
Journal Reference Authors Jenal U
Title The role of proteolysis in the Caulobacter crescentus cell cycle and development.
Journal Reference Authors Jenal U, Galperin MY
Title Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
Journal Reference Authors Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
Title Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
Journal Reference Authors Pawlowski K, Klosse U, de Bruijn FJ
Title Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
Journal Reference Authors Chatterjee S, Almeida RP, Lindow S
Title Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
Journal Reference Authors Dow M
Title Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
Journal Reference Authors Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
Title Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
Journal Reference Authors Miller LD, Russell MH, Alexandre G
Title Diversity in bacterial chemotactic responses and niche adaptation.
Journal Reference Authors Eder S, Shi L, Jensen K, Yamane K, Hulett FM
Title A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
Journal Related KO pathway LinkDB All DBs
