KEGG   PATHWAY: ecto03430
Entry
ecto03430                   Pathway                                
Name
Mismatch repair - Ectobacillus sp. JY-23
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
ecto03430  Mismatch repair
ecto03430

Other DBs
GO: 0006298
Organism
Ectobacillus sp. JY-23 [GN:ecto]
Gene
MUG87_05570  mutS; DNA mismatch repair protein MutS [KO:K03555]
MUG87_02585  endonuclease MutS2 [KO:K07456]
MUG87_09225  endonuclease MutS2 [KO:K07456]
MUG87_05565  mutL; DNA mismatch repair endonuclease MutL [KO:K03572]
MUG87_01335  UvrD-helicase domain-containing protein [KO:K03657] [EC:5.6.2.4]
MUG87_14050  pcrA; DNA helicase PcrA [KO:K03657] [EC:5.6.2.4]
MUG87_15970  UvrD-helicase domain-containing protein [KO:K03657] [EC:5.6.2.4]
MUG87_17355  ATP-dependent helicase [KO:K03657] [EC:5.6.2.4]
MUG87_19145  AAA family ATPase [KO:K03657] [EC:5.6.2.4]
MUG87_17805  AAA family ATPase [KO:K03657] [EC:5.6.2.4]
MUG87_07510  xseA; exodeoxyribonuclease VII large subunit [KO:K03601] [EC:3.1.11.6]
MUG87_07505  exodeoxyribonuclease VII small subunit [KO:K03602] [EC:3.1.11.6]
MUG87_08515  recJ; single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
MUG87_01225  ssb; single-stranded DNA-binding protein [KO:K03111]
MUG87_12480  ssb; single-stranded DNA-binding protein [KO:K03111]
MUG87_09435  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
MUG87_05830  PolC-type DNA polymerase III [KO:K03763] [EC:2.7.7.7]
MUG87_12565  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
MUG87_12680  dnaX; DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
MUG87_08165  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
MUG87_12745  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
MUG87_14055  ligA; NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair]
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   
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