KEGG   PATHWAY: ghi00030
Entry
ghi00030                    Pathway                                
Name
Pentose phosphate pathway - Gossypium hirsutum (upland cotton)
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
ghi00030  Pentose phosphate pathway
ghi00030

Module
ghi_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:ghi00030]
ghi_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ghi00030]
ghi_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:ghi00030]
ghi_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:ghi00030]
Other DBs
GO: 0006098
Organism
Gossypium hirsutum (upland cotton) [GN:ghi]
Gene
107922074  glucose-6-phosphate isomerase, cytosolic isoform X2 [KO:K01810] [EC:5.3.1.9]
107943319  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:5.3.1.9]
107918028  glucose-6-phosphate isomerase, cytosolic [KO:K01810] [EC:5.3.1.9]
107957810  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:5.3.1.9]
121230318  glucose-6-phosphate isomerase 1, chloroplastic-like [KO:K01810] [EC:5.3.1.9]
107886719  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107922783  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107912598  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107888699  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107899693  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107933096  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107909547  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107892194  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107886427  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107927241  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107926487  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107926532  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107887395  probable 6-phosphogluconolactonase 1 [KO:K01057] [EC:3.1.1.31]
107947200  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:3.1.1.31]
107920452  probable 6-phosphogluconolactonase 1 [KO:K01057] [EC:3.1.1.31]
107936207  probable 6-phosphogluconolactonase 1 [KO:K01057] [EC:3.1.1.31]
107893687  probable 6-phosphogluconolactonase 2 [KO:K01057] [EC:3.1.1.31]
107898049  probable 6-phosphogluconolactonase 1 [KO:K01057] [EC:3.1.1.31]
107916982  probable 6-phosphogluconolactonase 2 [KO:K01057] [EC:3.1.1.31]
107929572  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:3.1.1.31]
121230372  probable 6-phosphogluconolactonase 2 [KO:K01057] [EC:3.1.1.31]
107947100  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107954838  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107915537  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107950381  6-phosphogluconate dehydrogenase, decarboxylating 2 isoform X2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107947079  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
121219495  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107917647  ribulose-phosphate 3-epimerase, cytoplasmic isoform-like [KO:K01783] [EC:5.1.3.1]
107926357  ribulose-phosphate 3-epimerase, cytoplasmic isoform [KO:K01783] [EC:5.1.3.1]
107926380  ribulose-phosphate 3-epimerase, cytoplasmic isoform [KO:K01783] [EC:5.1.3.1]
107926703  ribulose-phosphate 3-epimerase, chloroplastic isoform X2 [KO:K01783] [EC:5.1.3.1]
107895534  ribulose-phosphate 3-epimerase, cytoplasmic isoform-like [KO:K01783] [EC:5.1.3.1]
107951272  ribulose-5-phosphate-3-epimerase, chloroplastic isoform X1 [KO:K01783] [EC:5.1.3.1]
107953525  ribulose-phosphate 3-epimerase, chloroplastic [KO:K01783] [EC:5.1.3.1]
121211034  ribulose-5-phosphate-3-epimerase, chloroplastic [KO:K01783] [EC:5.1.3.1]
107954570  transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
107941756  transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
107899903  LOW QUALITY PROTEIN: transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
107952895  transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
107945612  transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
107911586  transketolase, chloroplastic [KO:K00615] [EC:2.2.1.1]
121210881  transketolase, chloroplastic-like [KO:K00615] [EC:2.2.1.1]
107943944  transaldolase [KO:K00616] [EC:2.2.1.2]
107920503  transaldolase-like [KO:K00616] [EC:2.2.1.2]
107896514  transaldolase-like [KO:K00616] [EC:2.2.1.2]
107890651  transaldolase [KO:K00616] [EC:2.2.1.2]
107898983  transaldolase [KO:K00616] [EC:2.2.1.2]
121215926  transaldolase-like [KO:K00616] [EC:2.2.1.2]
107894773  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:5.3.1.6]
107886437  probable ribose-5-phosphate isomerase 2 [KO:K01807] [EC:5.3.1.6]
107888985  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:5.3.1.6]
107929815  probable ribose-5-phosphate isomerase 4, chloroplastic isoform X1 [KO:K01807] [EC:5.3.1.6]
107926830  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:5.3.1.6]
107946276  probable ribose-5-phosphate isomerase 2 isoform X1 [KO:K01807] [EC:5.3.1.6]
107902045  probable ribose-5-phosphate isomerase 4, chloroplastic isoform X1 [KO:K01807] [EC:5.3.1.6]
107916555  probable ribose-5-phosphate isomerase 2 [KO:K01807] [EC:5.3.1.6]
107920983  probable ribose-5-phosphate isomerase 2 [KO:K01807] [EC:5.3.1.6]
107898141  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:5.3.1.6]
107910027  probable ribose-5-phosphate isomerase 2 [KO:K01807] [EC:5.3.1.6]
107934514  probable ribose-5-phosphate isomerase 2 isoform X1 [KO:K01807] [EC:5.3.1.6]
107928375  ribokinase [KO:K00852] [EC:2.7.1.15]
107909173  ribokinase [KO:K00852] [EC:2.7.1.15]
107911553  phosphoglucomutase, cytoplasmic [KO:K01835] [EC:5.4.2.2]
107944052  phosphoglucomutase, chloroplastic [KO:K01835] [EC:5.4.2.2]
107947290  phosphoglucomutase, chloroplastic [KO:K01835] [EC:5.4.2.2]
107922163  phosphoglucomutase, cytoplasmic isoform X1 [KO:K01835] [EC:5.4.2.2]
121228298  phosphoglucomutase, cytoplasmic-like [KO:K01835] [EC:5.4.2.2]
107948609  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
107896299  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
107933537  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
107946732  ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
107943781  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
107907845  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
107920695  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
107906840  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00131] [EC:1.2.1.9]
107906909  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
107958926  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00131] [EC:1.2.1.9]
107953798  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase-like isoform X2 [KO:K00131] [EC:1.2.1.9]
107958996  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
107900478  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:1.2.1.9]
107912881  gluconokinase isoform X1 [KO:K00851] [EC:2.7.1.12]
107895294  gluconokinase-like [KO:K00851] [EC:2.7.1.12]
107926947  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
107918770  fructose-bisphosphate aldolase, cytoplasmic isozyme 1 [KO:K01623] [EC:4.1.2.13]
107903807  fructose-bisphosphate aldolase 3, chloroplastic [KO:K01623] [EC:4.1.2.13]
107948544  fructose-bisphosphate aldolase 6, cytosolic [KO:K01623] [EC:4.1.2.13]
107919978  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
107919979  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
107928128  fructose-bisphosphate aldolase 6, cytosolic [KO:K01623] [EC:4.1.2.13]
107945811  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
107913527  fructose-bisphosphate aldolase 1, chloroplastic-like [KO:K01623] [EC:4.1.2.13]
107913529  fructose-bisphosphate aldolase 1, chloroplastic [KO:K01623] [EC:4.1.2.13]
107959985  fructose-bisphosphate aldolase 3, chloroplastic isoform X1 [KO:K01623] [EC:4.1.2.13]
107905363  fructose-bisphosphate aldolase 6, cytosolic [KO:K01623] [EC:4.1.2.13]
107895164  fructose-bisphosphate aldolase, cytoplasmic isozyme 1-like [KO:K01623] [EC:4.1.2.13]
107899428  fructose-bisphosphate aldolase 6, cytosolic [KO:K01623] [EC:4.1.2.13]
121216173  fructose-bisphosphate aldolase 6, cytosolic-like [KO:K01623] [EC:4.1.2.13]
121228124  fructose-bisphosphate aldolase 6, cytosolic-like [KO:K01623] [EC:4.1.2.13]
107924622  fructose-1,6-bisphosphatase, cytosolic-like [KO:K03841] [EC:3.1.3.11]
107941694  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
107898531  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
107928931  fructose-1,6-bisphosphatase class 1-like [KO:K03841] [EC:3.1.3.11]
107910443  fructose-1,6-bisphosphatase, cytosolic-like [KO:K03841] [EC:3.1.3.11]
107932175  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:3.1.3.11]
107899022  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
107947382  fructose-1,6-bisphosphatase class 1 [KO:K03841] [EC:3.1.3.11]
107948854  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:3.1.3.11]
121223586  fructose-1,6-bisphosphatase, chloroplastic-like [KO:K03841] [EC:3.1.3.11]
121213706  fructose-1,6-bisphosphatase, cytosolic isoform X1 [KO:K03841] [EC:3.1.3.11]
121214610  fructose-1,6-bisphosphatase, cytosolic-like [KO:K03841] [EC:3.1.3.11]
107887310  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
107953863  ATP-dependent 6-phosphofructokinase 6-like isoform X1 [KO:K00850] [EC:2.7.1.11]
107907166  ATP-dependent 6-phosphofructokinase 3 isoform X1 [KO:K00850] [EC:2.7.1.11]
107958729  ATP-dependent 6-phosphofructokinase 3 isoform X1 [KO:K00850] [EC:2.7.1.11]
107894800  ATP-dependent 6-phosphofructokinase 7-like [KO:K00850] [EC:2.7.1.11]
107901151  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
107953618  ATP-dependent 6-phosphofructokinase 4, chloroplastic-like isoform X1 [KO:K00850] [EC:2.7.1.11]
107913191  ATP-dependent 6-phosphofructokinase 4, chloroplastic [KO:K00850] [EC:2.7.1.11]
107932044  ATP-dependent 6-phosphofructokinase 3-like isoform X2 [KO:K00850] [EC:2.7.1.11]
107905700  ATP-dependent 6-phosphofructokinase 2-like [KO:K00850] [EC:2.7.1.11]
107905736  ATP-dependent 6-phosphofructokinase 2-like [KO:K00850] [EC:2.7.1.11]
107949993  ATP-dependent 6-phosphofructokinase 5, chloroplastic isoform X1 [KO:K00850] [EC:2.7.1.11]
107901506  ATP-dependent 6-phosphofructokinase 3-like [KO:K00850] [EC:2.7.1.11]
107901507  ATP-dependent 6-phosphofructokinase 3-like [KO:K00850] [EC:2.7.1.11]
107951697  ATP-dependent 6-phosphofructokinase 5, chloroplastic [KO:K00850] [EC:2.7.1.11]
107929968  ATP-dependent 6-phosphofructokinase 6 isoform X1 [KO:K00850] [EC:2.7.1.11]
107897082  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:2.7.1.11]
107941714  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
107963121  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
107912636  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta-like [KO:K00895] [EC:2.7.1.90]
107935397  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
107951094  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:2.7.1.90]
107948223  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha isoform X1 [KO:K00895] [EC:2.7.1.90]
107910055  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:2.7.1.90]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
PMID:12700258
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
PMID:16788179
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
PMID:16428816
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
PMID:23279921
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
PMID:16458304
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
PMID:20023024
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
ghi00010  Glycolysis / Gluconeogenesis
ghi00040  Pentose and glucuronate interconversions
ghi00052  Galactose metabolism
ghi00230  Purine metabolism
ghi00240  Pyrimidine metabolism
ghi00340  Histidine metabolism
ghi00630  Glyoxylate and dicarboxylate metabolism
ghi00750  Vitamin B6 metabolism
KO pathway
ko00030   
LinkDB

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