KEGG   PATHWAY: halm00260
Entry
halm00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Haloprofundus sp. MHR1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
halm00260  Glycine, serine and threonine metabolism
halm00260

Module
halm_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:halm00260]
halm_M00621  Glycine cleavage system [PATH:halm00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Haloprofundus sp. MHR1 [GN:halm]
Gene
FCF25_06725  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FCF25_04610  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FCF25_09110  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
FCF25_03545  homoserine kinase [KO:K00872] [EC:2.7.1.39]
FCF25_07200  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
FCF25_06560  threonine synthase [KO:K01733] [EC:4.2.3.1]
FCF25_11045  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
FCF25_08425  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
FCF25_07795  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
FCF25_05510  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FCF25_00010  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
FCF25_14685  DUF4147 domain-containing protein [KO:K11529] [EC:2.7.1.165]
FCF25_04060  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
FCF25_06575  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FCF25_06580  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
FCF25_04385  aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
FCF25_04390  glycine dehydrogenase subunit 2 [KO:K00283] [EC:1.4.4.2]
FCF25_04375  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
FCF25_08735  aminomethyl transferase family protein [KO:K00605] [EC:2.1.2.10]
FCF25_06375  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
FCF25_04380  gcvH; glycine cleavage system protein GcvH [KO:K02437]
FCF25_01280  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01758] [EC:4.4.1.1]
FCF25_05165  cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
FCF25_04350  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
FCF25_14275  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
FCF25_08355  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
FCF25_10570  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
FCF25_10575  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
halm00010  Glycolysis / Gluconeogenesis
halm00020  Citrate cycle (TCA cycle)
halm00230  Purine metabolism
halm00250  Alanine, aspartate and glutamate metabolism
halm00270  Cysteine and methionine metabolism
halm00290  Valine, leucine and isoleucine biosynthesis
halm00300  Lysine biosynthesis
halm00330  Arginine and proline metabolism
halm00460  Cyanoamino acid metabolism
halm00470  D-Amino acid metabolism
halm00564  Glycerophospholipid metabolism
halm00620  Pyruvate metabolism
halm00630  Glyoxylate and dicarboxylate metabolism
halm00640  Propanoate metabolism
halm00680  Methane metabolism
halm00860  Porphyrin metabolism
halm00920  Sulfur metabolism
KO pathway
ko00260   
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