KEGG   PATHWAY: hme00730
Entry
hme00730                    Pathway                                
Name
Thiamine metabolism - Haloferax mediterranei
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
hme00730  Thiamine metabolism
hme00730

Module
hme_M00896  Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:hme00730]
hme_M00899  Thiamine salvage pathway, HMP/HET => TMP [PATH:hme00730]
Other DBs
GO: 0006772
Organism
Haloferax mediterranei [GN:hme]
Gene
HFX_2195  thiC; thiamine biosynthesis protein ThiC [KO:K03147] [EC:4.1.99.17]
HFX_2683  thiD; phosphomethylpyrimidine kinase [KO:K21219] [EC:2.7.1.49 2.7.4.7 2.5.1.3]
HFX_1741  thiI; thiamine biosynthesis protein ThiI [KO:K03151] [EC:2.8.1.4]
HFX_0634  ribulose-1,5-biphosphate synthetase [KO:K22699] [EC:2.4.2.59]
HFX_2684  thiM; hydroxyethylthiazole kinase [KO:K00878] [EC:2.7.1.50]
HFX_2685  thiE; thiamine-phosphate pyrophosphorylase [KO:K00788] [EC:2.5.1.3]
HFX_1943  thiL; thiamine monophosphate kinase [KO:K00946] [EC:2.7.4.16]
HFX_2510  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
HFX_5295  tenA-2; transcriptional activator TenA [KO:K03707] [EC:3.5.99.2]
HFX_5296  tenA; transcriptional activator TenA [KO:K03707] [EC:3.5.99.2]
Compound
C00003  NAD+
C00018  Pyridoxal phosphate
C00022  Pyruvate
C00037  Glycine
C00068  Thiamin diphosphate
C00082  L-Tyrosine
C00097  L-Cysteine
C00118  D-Glyceraldehyde 3-phosphate
C00378  Thiamine
C01081  Thiamin monophosphate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C02892  Thiamine acetic acid
C03028  Thiamin triphosphate
C03373  Aminoimidazole ribotide
C04294  5-(2-Hydroxyethyl)-4-methylthiazole
C04327  4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556  4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752  4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C05856  Thiamine aldehyde
C11437  1-Deoxy-D-xylulose 5-phosphate
C15809  Iminoglycine
C15810  Sulfur-carrier protein
C15811  [Enzyme]-cysteine
C15812  [Enzyme]-S-sulfanylcysteine
C15813  Adenylyl-[sulfur-carrier protein]
C15814  Thiocarboxy-[sulfur-carrier protein]
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246  2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247  2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267  4-Amino-5-aminomethyl-2-methylpyrimidine
C20784  ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
PMID:15614489
  Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
  Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
  Journal
Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x
Reference
PMID:14567704
  Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
  Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
  Journal
Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z
Reference
PMID:22616866
  Authors
Begley TP, Ealick SE, McLafferty FW
  Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
  Journal
Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084
Reference
PMID:12777485
  Authors
Wightman R, Meacock PA
  Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
  Journal
Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0
Reference
PMID:22031445
  Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
  Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
  Journal
Nature 478:542-6 (2011)
DOI:10.1038/nature10503
Reference
PMID:19348578
  Authors
Jurgenson CT, Begley TP, Ealick SE
  Title
The structural and biochemical foundations of thiamin biosynthesis.
  Journal
Annu Rev Biochem 78:569-603 (2009)
DOI:10.1146/annurev.biochem.78.072407.102340
Related
pathway
hme00010  Glycolysis / Gluconeogenesis
hme00230  Purine metabolism
hme00260  Glycine, serine and threonine metabolism
hme00270  Cysteine and methionine metabolism
hme00400  Phenylalanine, tyrosine and tryptophan biosynthesis
hme00750  Vitamin B6 metabolism
KO pathway
ko00730   
LinkDB

DBGET integrated database retrieval system